scholarly journals Costimulatory Blockade-Induced Allograft Survival Requires Beclin1

2014 ◽  
Vol 14 (3) ◽  
pp. 545-553 ◽  
Author(s):  
D. A. Verghese ◽  
A. Yadav ◽  
P. Bizargity ◽  
B. Murphy ◽  
P. S. Heeger ◽  
...  
Keyword(s):  
Allograft Survival ◽  
Costimulatory Blockade

scholarly journals C5aR1 regulates migration of suppressive myeloid cells required for costimulatory blockade‐induced murine allograft survival

2018 ◽  
Vol 19 (3) ◽  
pp. 633-645 ◽  
Author(s):  
Ines Llaudo ◽  
Miguel Fribourg ◽  
M. Edward Medof ◽  
Patricia Conde ◽  
Jordi Ochando ◽  
...  
Keyword(s):  
Myeloid Cells ◽  
Allograft Survival ◽  
Costimulatory Blockade

scholarly journals Berberine Promotes Induction of Immunological Tolerance to an Allograft via Downregulating Memory CD8+ T-Cells Through Altering the Gut Microbiota

2021 ◽  
Vol 12 ◽  
Author(s):  
Feifei Qiu ◽  
Weihui Lu ◽  
Shulin Ye ◽  
Huazhen Liu ◽  
Qiaohuang Zeng ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Gut Microbiota ◽  
Memory T Cells ◽  
Transplant Rejection ◽  
Therapeutic Effects ◽  
Allograft Survival ◽  
Islet Allograft ◽  
Costimulatory Blockade

Emerging evidence has linked the gut microbiota dysbiosis to transplant rejection while memory T-cells pose a threat to long-term transplant survival. However, it's unclear if the gut microbiome alters the formation and function of alloreactive memory T-cells. Here we studied the effects of berberine, a narrow-spectrum antibiotic that is barely absorbed when orally administered, on the gut microbiota, memory T-cells, and allograft survival. In this study, C57BL/6 mice transplanted with islets or a heart from BALB/c mice were treated orally with berberine. Allograft survival was observed, while spleen, and lymph node T-cells from recipient mice were analyzed using a flow cytometer. High-throughput sequencing and qPCR were performed to analyze the gut microbiota. CD8+ T-cells from recipients were cultured with the bacteria to determine potential T-cell memory cross-reactivity to a specific pathogen. We found that berberine suppressed islet allograft rejection, reduced effector CD8+CD44highCD62Llow and central memory CD8+CD44highCD62Lhigh T-cells (TCM), altered the gut microbiota composition and specifically lowered Bacillus cereus abundance. Further, berberine promoted long-term islet allograft survival induced by conventional costimulatory blockade and induced cardiac allograft tolerance as well. Re-colonization of B. cereus upregulated CD8+ TCM cells and reversed long-term islet allograft survival induced by berberine plus the conventional costimulatory blockade. Finally, alloantigen-experienced memory CD8+ T-cells from transplanted recipients rapidly responded to B. cereus in vitro. Thus, berberine prolonged allograft survival by repressing CD8+ TCM through regulating the gut microbiota. We have provided the first evidence that donor-specific memory T-cell generation is linked to a specific microbe and uncovered a novel mechanism underlying the therapeutic effects of berberine. This study may be implicated for suppressing human transplant rejection since berberine is already used in clinic to treat intestinal infections.

scholarly journals Neutralizing IL-7 Promotes Long-Term Allograft Survival Induced by CD40/CD40L Costimulatory Blockade

2006 ◽  
Vol 6 (12) ◽  
pp. 2851-2860 ◽  
Author(s):  
Y. Wang ◽  
H. Dai ◽  
Z. Liu ◽  
X. Cheng ◽  
G. Tellides ◽  
...  
Keyword(s):  
Allograft Survival ◽  
Costimulatory Blockade

scholarly journals CD8+CD122+PD-1+ Tregs Synergize With Costimulatory Blockade of CD40/CD154, but Not B7/CD28, to Prolong Murine Allograft Survival

2019 ◽  
Vol 10 ◽  
Author(s):  
Huazhen Liu ◽  
Feifei Qiu ◽  
Yuanzhong Wang ◽  
Qiaohuang Zeng ◽  
Cuihua Liu ◽  
...  
Keyword(s):  
Allograft Survival ◽  
Costimulatory Blockade

Promotion of pancreatic islet allograft survival by intrathymic transplantation of bone marrow

Diabetes ◽  
1992 ◽  
Vol 41 (6) ◽  
pp. 771-775 ◽  
Author(s):  
A. M. Posselt ◽  
J. S. Odorico ◽  
C. F. Barker ◽  
A. Naji
Keyword(s):  
Bone Marrow ◽  
Pancreatic Islet ◽  
Allograft Survival ◽  
Islet Allograft ◽  
Pancreatic Islet Allograft

Ultraviolet light immunomodulation of canine islets for prolongation of allograft survival

Diabetes ◽  
1990 ◽  
Vol 39 (3) ◽  
pp. 305-311 ◽  
Author(s):  
N. S. Kenyon ◽  
S. Strasser ◽  
R. Alejandro
Keyword(s):  
Ultraviolet Light ◽  
Allograft Survival
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