Randomized Controlled Pilot Study of B Cell-Targeted Induction Therapy in HLA Sensitized Kidney Transplant Recipients

2013 ◽  
Vol 13 (12) ◽  
pp. 3142-3154 ◽  
Author(s):  
N. S. Ejaz ◽  
A. R. Shields ◽  
R. R. Alloway ◽  
B. Sadaka ◽  
A. L. Girnita ◽  
...  
Keyword(s):  
Pilot Study ◽  
B Cell ◽  
Kidney Transplant ◽  
Induction Therapy ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Randomized Controlled

Kinetic of the CMV-specific T-cell immune response and CMV infection in CMV-seropositive kidney transplant recipients receiving rabbit anti-thymocyte globulin induction therapy: A pilot study

2018 ◽  
Vol 20 (3) ◽  
pp. e12883 ◽  
Author(s):  
Cecilia Martín-Gandul ◽  
Pilar Pérez-Romero ◽  
Damián Mena-Romo ◽  
Alejandro Molina-Ortega ◽  
Francisco M. González-Roncero ◽  
...  
Keyword(s):  
Immune Response ◽  
T Cell ◽  
Pilot Study ◽  
Kidney Transplant ◽  
Induction Therapy ◽  
Cell Immune Response ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Cmv Infection

Immunosuppressive Management of Pediatric Kidney Transplant Recipients

2020 ◽  
Vol 26 (28) ◽  
pp. 3451-3459
Author(s):  
Tomáš Seeman
Keyword(s):  
Immunosuppressive Therapy ◽  
Kidney Transplant ◽  
Induction Therapy ◽  
Graft Loss ◽  
Calcineurin Inhibitors ◽  
Mtor Inhibitors ◽  
Therapeutic Drug ◽  
High Dose ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients

: Kidney transplantation is a preferable treatment of children with end-stage kidney disease. All kidney transplant recipients, including pediatric need immunosuppressive medications to prevent rejection episodes and graft loss. : Induction therapy is used temporarily only immediately following transplantation while maintenance immunosuppressive drugs are started and given long-term. There is currently no consensus regarding the use of induction therapy in children; its use should be decided based on the immunological risk of the child. : The recent progress shows that the recommended strategy is to use as maintenance immunosuppressive therapy a combination of a calcineurin inhibitor (preferably tacrolimus) with an antiproliferative drug (preferably mycophenolate mofetil) with steroids that can be withdrawn early or late in low-risk children. The mTOR-inhibitors (sirolimus, everolimus) are used rarely in pediatrics because of common side effects and no evidence of a benefit over calcineurin inhibitors. The use of calcineurin inhibitors, mycophenolate, and mTOR-inhibitors should be followed by therapeutic drug monitoring. : Immunosuppressive therapy of acute rejection consists of high-dose steroids and/or anti-lymphocyte antibodies (T-cell mediated rejection) or plasma exchange, intravenous immunoglobulines and/or rituximab (antibodymediated rejection). : The future strategies for research are mainly precise characterisation of children needing induction therapy, more specific indications for mTOR-inhibitors and for the far future, the possibility to reach the immuno tolerance.

Role of induction therapy in low immunological risk-kidney transplant recipients: A mate-kidney analysis

2019 ◽  
pp. e13442 ◽  
Author(s):  
Kalathil K. Sureshkumar ◽  
Vinaikumar Katragadda ◽  
Bhavna Chopra ◽  
Marcelo Sampaio
Keyword(s):  
Kidney Transplant ◽  
Induction Therapy ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients

A randomized clinical trial comparing Nitrofurazone‐coated and uncoated urinary catheters in kidney transplant recipients: Results from a pilot study

2018 ◽  
Vol 21 (2) ◽  
pp. e13031 ◽  
Author(s):  
Fernando Gatti Menezes ◽  
Luci Corrêa ◽  
Jose Osmar Medina‐Pestana ◽  
Wilson Ferreira Aguiar ◽  
Luis Fernando Aranha Camargo
Keyword(s):  
Clinical Trial ◽  
Pilot Study ◽  
Randomized Clinical Trial ◽  
Kidney Transplant ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Urinary Catheters

scholarly journals Optimal Dose of Thymoglobulin for Induction Therapy in High Risk Kidney Transplant Recipients

2016 ◽  
Vol 30 (2) ◽  
pp. 82
Author(s):  
Yaerim Kim ◽  
Seong Sik Kang ◽  
Woo Yeong Park ◽  
Kyubok Jin ◽  
Sung Bae Park ◽  
...  
Keyword(s):  
High Risk ◽  
Kidney Transplant ◽  
Induction Therapy ◽  
Optimal Dose ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients
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