Epstein-Barr Virus Infection and Posttransplant Lymphoproliferative Disorder

2013 ◽  
Vol 13 (s3) ◽  
pp. 41-54 ◽  
Author(s):  
M. Green ◽  
M. G. Michaels
Keyword(s):  
Virus Infection ◽  
Lymphoproliferative Disorder ◽  
Epstein Barr Virus ◽  
Epstein Barr Virus Infection ◽  
Posttransplant Lymphoproliferative Disorder ◽  
Barr Virus ◽  
Epstein Barr ◽  
Barr Virus Infection

scholarly journals A new therapy in Epstein-Barr virus-associated lymphoproliferative disease: a case report and a revision of the literature

2019 ◽  
Vol 45 (1) ◽  
Author(s):  
Lingling Xu ◽  
Hongjun Ba ◽  
Hongrong Lin ◽  
Liangying Zhong ◽  
Suping Li ◽  
...  
Keyword(s):  
Virus Infection ◽  
Lymphoproliferative Disorder ◽  
Epstein Barr Virus ◽  
Internal Carotid ◽  
Lymphoproliferative Disease ◽  
Epstein Barr Virus Infection ◽  
Barr Virus ◽  
Epstein Barr ◽  
Barr Virus Infection ◽  
The Right

Abstract Background Systemic chronic active Epstein-Barr virus infection is an extremely rare childhood disease. Since chronic active Epstein-Barr virus infection can trigger the onset of Epstein-Barr virus-associated lymphoproliferative disease. The clinical manifestations of the disease vary according to the site of involvement; therefore, management may be challenging. Currently, there are no standardized guidelines for treating Chronic active Epstein-Barr virus infection effectively. Case presentation We report a case of chronic active Epstein-Barr virus infection in a 5-year-old Chinese boy with intestinal, vascular, and neurological involvement. At age of 2 years and 7 months old, he had hepatomegaly and been diagnosed with Epstein-Barr virus infection. After treatment, he showed some clinical improvement. At age of 3 years and 3 months old, he presented with recurrent fever and diarrhea. Then he received methylprednisolone for 1 year and his symptoms ameliorated. At the age of 5 years, his symptoms recurred and had gastrointestinal hemorrhage and developed polyuria, frequent convulsions and hyponatremia. He was transferred to our hospital for further management. He was unconscious on admission and was diagnosised Epstein-Barr virus-lymphoproliferative disorder, based on the results in situ hybridization of EBV-encoded miRNA in sigmoid colon. Three-dimensional CT angiography demonstrated an aneurysm in the right internal carotid artery. Abdominal CT showed dilatation of vessels in part of the intestinal wall. He was also diagnosised Epstein-Barr virus encephalitis based on the elevated Epstein-Barr virus antibody titers and presence of Epstein-Barr virus DNA in the Cerebrospinal Fluid. A repeated duodenal artery embolization and symptomatic therapy could not control the hemorrhage after admission. He subsequently received treatment with ganciclovir, glucocorticoid, thalidomide, and propranolol. Hemorrhage was controlled in 5 days; his symptoms improved. The fever did not recur and the CSF pressure was also normalized. A follow-up CT at 3 months after admission showed regression of the aneurysm in the right internal carotid artery and the vascular lesion in the duodenum. Discussion and conclusions A new treatment protocol including thalidomide and propranolol resulted in a marked improvement in his clinical symptoms, and shows promise as a novel and effective therapeutic approach for Chronic active Epstein-Barr virus infection-associated lymphoproliferative disorder.

scholarly journals A Case of Severe Chronic Active Epstein-Barr Virus Infection with T-cell lymphoproliferative Disorder

2004 ◽  
Vol 19 (2) ◽  
pp. 124-127 ◽  
Author(s):  
Hyun Seok Cho ◽  
In Soon Kim ◽  
Hwan Cheol Park ◽  
Myung Ju Ahn ◽  
Young Yiul Lee ◽  
...  
Keyword(s):  
T Cell ◽  
Virus Infection ◽  
Lymphoproliferative Disorder ◽  
Epstein Barr Virus ◽  
Epstein Barr Virus Infection ◽  
Barr Virus ◽  
Epstein Barr ◽  
Barr Virus Infection

Epstein–Barr virus infection: from infectious mononucleosis to lymphoproliferative disorder

Therapy ◽  
2021 ◽  
Vol 2_2021 ◽  
pp. 112-122
Author(s):  
Mazus A.I. Mazus ◽  
Tsyganova E.V. Tsyganova ◽  
Glukhoedova N.V. Glukhoedova ◽  
Zhilenkova A.S. Zhilenkova ◽  
Keyword(s):  
Virus Infection ◽  
Infectious Mononucleosis ◽  
Lymphoproliferative Disorder ◽  
Epstein Barr Virus ◽  
Epstein Barr Virus Infection ◽  
Barr Virus ◽  
Epstein Barr ◽  
Barr Virus Infection

AN INCREASED INCIDENCE OF EPSTEIN-BARR VIRUS INFECTION AND LYMPHOPROLIFERATIVE DISORDER IN YOUNG CHILDREN ON FK506 AFTER LIVER TRANSPLANTATION1

1995 ◽  
Vol 59 (4) ◽  
pp. 524-529 ◽  
Author(s):  
Kenneth L. Cox ◽  
Lisa S. Lawrence-Miyasaki ◽  
Richard Garcia-Kennedy ◽  
Evelyne T. Lennette ◽  
Olivia M. Martinez ◽  
...  
Keyword(s):  
Virus Infection ◽  
Young Children ◽  
Lymphoproliferative Disorder ◽  
Epstein Barr Virus ◽  
Epstein Barr Virus Infection ◽  
Barr Virus ◽  
Epstein Barr ◽  
Barr Virus Infection

Successful treatment of acute Epstein–Barr virus infection associated with X-linked lymphoproliferative disorder with rituximab

2007 ◽  
Vol 49 (5) ◽  
pp. 761-762 ◽  
Author(s):  
Jonathan Bond ◽  
Raveen Shahdadpuri ◽  
Corrina Mc Mahon ◽  
Aengus O'Marcaigh ◽  
Melanie Cotter ◽  
...  
Keyword(s):  
Virus Infection ◽  
Successful Treatment ◽  
Lymphoproliferative Disorder ◽  
Epstein Barr Virus ◽  
Epstein Barr Virus Infection ◽  
Barr Virus ◽  
Epstein Barr ◽  
Barr Virus Infection

Identification of Epstein-Barr Virus Lytic and Latent RNA Transcripts in Post-transplant Lymphoproliferative Disorder

1995 ◽  
Vol 3 (2) ◽  
pp. 119-130 ◽  
Author(s):  
Kathleen T. Montone ◽  
Richard L. Hodinka ◽  
John E. Tomaszewski
Keyword(s):  
Virus Infection ◽  
Lymphoproliferative Disorder ◽  
Epstein Barr Virus ◽  
Lytic Activity ◽  
Epstein Barr Virus Infection ◽  
Transplant Recipients ◽  
Post Transplant ◽  
Barr Virus ◽  
Epstein Barr ◽  
Barr Virus Infection

Thirty-three specimens from 25 transplant recipients with Epstein-Barr virus-associated lymphoproliferative disease were studied by in situ hybridization for 2 lytic and 4 latent Epstein-Barr virus transcripts. All specimens were found to contain at least 1 latent transcript while 28 were positive for at least 1 lytic transcript. The amount of Epstein-Barr virus infection and lytic activity varied with histopathology and number of involved sites. Patients with localized polymorphous disease contained the lowest number of infected cells with an almost equal lytic:latent ratio. Disseminated polymorphous and single and multisite monomorphous specimens showed a large latent cell population. Minimal lytic activity was seen in single site monomorphous specimens, but disseminated monomorphous specimens showed the highest levels of lytic transcripts. Most post-transplant lymphoproliferative disorder specimens demonstrate lytic Epstein-Barr virus transcripts, although the majority of cells contain latent Epstein-Barr virus. Lytic activity is highest in patients with disseminated disease. Lytic Epstein-Barr virus infection may aid in the development and maintenance of lymphoproliferative disorders in transplant recipients.

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