P10: Galectin‐9/CD44 signaling‐induced pro‐inflammatory CD11chigh macrophages contribute to the compromised spiral artery remodeling in preeclampsia

2021 ◽  
Vol 85 (S1) ◽  
pp. 67-68
Keyword(s):  
Spiral Artery ◽  
Artery Remodeling

scholarly journals Inhibition of Trophoblast-Induced Spiral Artery Remodeling Reduces Placental Perfusion in Rat Pregnancy

Hypertension ◽  
2010 ◽  
Vol 56 (2) ◽  
pp. 304-310 ◽  
Author(s):  
Stefan Verlohren ◽  
Nele Geusens ◽  
Jude Morton ◽  
Iris Verhaegen ◽  
Lydia Hering ◽  
...  
Keyword(s):  
Spiral Artery ◽  
Placental Perfusion ◽  
Artery Remodeling

scholarly journals Baboon placental heparin-binding epidermal growth factor-like growth factor

Reproduction ◽  
2020 ◽  
Vol 160 (1) ◽  
pp. 31-37
Author(s):  
D Randall Armant ◽  
Graham W Aberdeen ◽  
Brian A Kilburn ◽  
Gerald J Pepe ◽  
Eugene D Albrecht
Keyword(s):  
Growth Factor ◽  
First Trimester ◽  
Extravillous Trophoblast ◽  
Immunocytochemical Staining ◽  
Heparin Binding ◽  
Spiral Artery ◽  
Primate Model ◽  
Artery Remodeling ◽  
Egf Family

Placental extravillous trophoblast remodeling of the uterine spiral arteries is important for promoting blood flow to the placenta and fetal development. Heparin-binding EGF-like growth factor (HB-EGF), an EGF family member, stimulates differentiation and invasive capacity of extravillous trophoblasts in vitro. Trophoblast expression and maternal levels of HB-EGF are reduced at term in women with preeclampsia, but it is uncertain whether HB-EGF is downregulated earlier when it may contribute to placental insufficiency. A nonhuman primate model has been established in which trophoblast remodeling of the uterine spiral arteries is suppressed by shifting the rise in estrogen from the second to the first trimester of baboon pregnancy. In the present study, we used this model to determine if placental HB-EGF is altered by prematurely elevating estrogen early in baboon gestation. Uterine spiral artery remodeling and placental expression of HB-EGF and other EGF family members were assessed on day 60 of gestation in baboons treated with estradiol (E2) daily between days 25 and 59 of gestation (term = 184 days). The percentages of spiral artery remodeling were 90, 84 and 70% lower (P < 0.01), respectively, for vessels of 26–50, 51–100 and >100 µm diameter in E2-treated compared with untreated baboons. HB-EGF protein quantified by immunocytochemical staining/image analysis was decreased three-fold (P < 0.01) in the placenta of E2-treated versus untreated baboons, while amphiregulin (AREG) and EGF expression was unaltered. Therefore, we propose that HB-EGF modulates the estrogen-sensitive remodeling of the uterine spiral arteries by the extravillous trophoblast in early baboon pregnancy.

Defective spiral artery remodeling

2010 ◽  
pp. 11-21 ◽  
Author(s):  
Ivo Brosens ◽  
T. Yee Khong
Keyword(s):  
Spiral Artery ◽  
Artery Remodeling

scholarly journals Corin, an enzyme with a putative role in spiral artery remodeling, is up-regulated in late secretory endometrium and first trimester decidua

2013 ◽  
Vol 28 (5) ◽  
pp. 1172-1180 ◽  
Author(s):  
T. J. Kaitu'u-Lino ◽  
L. Ye ◽  
L. Tuohey ◽  
E. Dimitriadis ◽  
J. Bulmer ◽  
...  
Keyword(s):  
First Trimester ◽  
Spiral Artery ◽  
Putative Role ◽  
Artery Remodeling ◽  
Secretory Endometrium
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