P84: A novel signaling molecule ‘lactic acid’ derived from trophoblasts can modulate macrophage polarization in early pregnancy

2021 ◽  
Vol 85 (S1) ◽  
pp. 102-103
Keyword(s):  
Lactic Acid ◽  
Early Pregnancy ◽  
Macrophage Polarization ◽  
Signaling Molecule

scholarly journals Lactic Acid: A Novel Signaling Molecule in Early Pregnancy?

2020 ◽  
Vol 11 ◽  
Author(s):  
Li-Na Ma ◽  
Xiao-Bo Huang ◽  
Kahindo P. Muyayalo ◽  
Gil Mor ◽  
Ai-Hua Liao
Keyword(s):  
Lactic Acid ◽  
Early Pregnancy ◽  
Signaling Molecule

scholarly journals The influence of surface modified poly(l-lactic acid) films on the differentiation of human monocytes into macrophages

2017 ◽  
Vol 5 (3) ◽  
pp. 551-560 ◽  
Author(s):  
Clara R. Correia ◽  
Joana Gaifem ◽  
Mariana B. Oliveira ◽  
Ricardo Silvestre ◽  
João F. Mano
Keyword(s):  
Lactic Acid ◽  
Macrophage Polarization ◽  
Human Monocytes ◽  
Anti Inflammatory ◽  
Inflammatory Profile ◽  
Surface Modified

The interaction of human monocytes with different surface modified poly(l-lactic acid) films was evaluated. All surface modified films disrupted the balance of macrophage polarization towards a favorable anti-inflammatory profile, particularly after an LPS stimulus.

scholarly journals M2‐like macrophage polarization in high lactic acid‐producing head and neck cancer

2017 ◽  
Vol 108 (6) ◽  
pp. 1128-1134 ◽  
Author(s):  
Toshimitsu Ohashi ◽  
Mitsuhiro Aoki ◽  
Hiroyuki Tomita ◽  
Takashi Akazawa ◽  
Katsuya Sato ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Lactic Acid ◽  
Head And Neck ◽  
Neck Cancer ◽  
Macrophage Polarization

scholarly journals Trophoblast-derived Lactic Acid Orchestrates Decidual Macrophage Differentiation via SRC/LDHA Signaling in Early Pregnancy

2022 ◽  
Vol 18 (2) ◽  
pp. 599-616
Author(s):  
Lu Gao ◽  
Qian-Han Xu ◽  
Li-Na Ma ◽  
Jing Luo ◽  
Kahindo P. Muyayalo ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Early Pregnancy ◽  
Macrophage Differentiation

scholarly journals Lactic acid in macrophage polarization: The significant role in inflammation and cancer

2021 ◽  
pp. 1-15
Author(s):  
Hai-cun Zhou ◽  
Xin-yan Yan ◽  
Wen-wen Yu ◽  
Xiao-qin Liang ◽  
Xiao-yan Du ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Significant Role ◽  
Macrophage Polarization

scholarly journals Lactic Acid-Producing Probiotic Saccharomyces cerevisiae Attenuates Ulcerative Colitis via Suppressing Macrophage Pyroptosis and Modulating Gut Microbiota

2021 ◽  
Vol 12 ◽  
Author(s):  
Siyuan Sun ◽  
Xiuxiu Xu ◽  
Ling Liang ◽  
Xiaoli Wang ◽  
Xue Bai ◽  
...  
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Ulcerative Colitis ◽  
Lactic Acid ◽  
Intestinal Microbiota ◽  
Macrophage Polarization ◽  
Polarization State ◽  
Mucosal Barrier ◽  
Acid Uptake ◽  
Signal Molecule

Lactic acid, a metabolic by-product of host and intestinal microbiota, has been recovered as an active signal molecule in the immune system. In this study, a lactic acid biosynthesis pathway that directly produces lactic acid from glucose rather than ethanol with high production was reconstructed in Saccharomyces cerevisiae. The engineered S. cerevisiae showed anti-inflammatory activity in dextran sulfate sodium (DSS)-induced mice with improved histological damage, increased mucosal barrier, and decreased intestinal immune response. Lactic acid regulated the macrophage polarization state and inhibited the expression of pro-inflammatory cytokines in vivo and in vitro. Increasing the macrophage monocarboxylic acid transporter-mediated active lactic acid uptake suppressed the excessive activation of the NLRP3 inflammasome and the downstream caspase-1 pathway in macrophages. Moreover, lactic acid promoted histone H3K9 acetylation and histone H3K18 lactylation. Meanwhile, the engineered S. cerevisiae altered the diversity and composition of the intestinal microbiota and changed the abundance of metabolic products in mice with colitis. In conclusion, this study shows that the application of engineered S. cerevisiae attenuated DSS-induced colitis in mice via suppressing macrophage pyroptosis and modulating the intestinal microbiota, which is an effective and safe treatment strategy for ulcerative colitis.

Effect of ovulation and early gestation on oviduct secretions in the rabbit

1961 ◽  
Vol 200 (4) ◽  
pp. 815-818 ◽  
Author(s):  
Luigi Mastroianni ◽  
Robert C. Wallach
Keyword(s):  
Lactic Acid ◽  
New Zealand ◽  
Early Pregnancy ◽  
Sugar Content ◽  
Sodium Concentration ◽  
Reducing Sugar ◽  
Lactic Acid Concentration ◽  
Early Gestation ◽  
New Zealand White Rabbits ◽  
Similar Decrease

A system for continuous, volumetric collection of oviduct secretions was applied to New Zealand White rabbits. After 3 or more days, animals were mated. The secretion rate decreased on the 2nd and 3rd days of pregnancy. It leveled off at about 50% of the estrous rate and then remained steady during the succeeding 7 days. A similar decrease in rate was observed in pseudopregnancy. No decrease was observed in animals that rejected the male or in one that mated but failed to become either pregnant or pseudopregnant. The sodium concentration was significantly lower in the first 3 days of pregnancy (mean 142.6 mEq/l.) than in estrus (mean 144.5 mEq/l.). A significant change in potassium (mean 6.2 mEq/l.) and chloride (mean 118.7 mEq/l.) levels was not demonstrated. The reducing sugar content (mean 6 mg %) displayed no variation in relation to ovulation. Glycine, glutamic acid, alanine, valine and leucine were consistently present. The lactic acid concentration varied widely among the animals (range 4.4–51.0 mg%). In the group, it was increased significantly in early pregnancy.

scholarly journals Machilin A Inhibits Tumor Growth and Macrophage M2 Polarization Through the Reduction of Lactic Acid

Cancers ◽  
2019 ◽  
Vol 11 (7) ◽  
pp. 963
Author(s):  
Tae-Wook Chung ◽  
Eun-Yeong Kim ◽  
Chang Woo Han ◽  
So Young Park ◽  
Mi Suk Jeong ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Tumor Growth ◽  
Cancer Cells ◽  
Cancer Cell ◽  
Macrophage Polarization ◽  
Lactate Production ◽  
Competitive Inhibitor ◽  
Alternatively Activated Macrophages ◽  
M2 Polarization ◽  
Liver Cancers

Lactate dehydrogenase A (LDHA) is an important enzyme responsible for cancer growth and energy metabolism in various cancers via the aerobic glycolytic pathway. Here, we report that machilin A (MA), which acts as a competitive inhibitor by blocking the nicotinamide adenine dinucleotide (NAD) binding site of LDHA, suppresses growth of cancer cells and lactate production in various cancer cell types, including colon, breast, lung, and liver cancers. Furthermore, MA markedly decreased LDHA activity, lactate production, and intracellular adenosine triphosphate (ATP) levels induced by hypoxia-induced LDHA expression in cancer cells, and significantly inhibited colony formation, leading to reduced cancer cell survival. In mouse models inoculated with murine Lewis lung carcinoma, MA significantly suppressed tumor growth as observed by a reduction of tumor volume and weight; resulting from the inhibition of LDHA activity. Subsequently, the suppression of tumor-derived lactic acid in MA-treated cancer cells resulted in decrease of neovascularization through the regulation of alternatively activated macrophages (M2) polarization in macrophages. Taken together, we suggest that the reduction of lactate by MA in cancer cells directly results in a suppression of cancer cell growth. Furthermore, macrophage polarization and activation of endothelial cells for angiogenesis were indirectly regulated preventing lactate production in MA-treated cancer cells.

Demonstration of Retinal Glycogen with Silver Methenamine

1971 ◽  
Vol 29 ◽  
pp. 564-565
Author(s):  
A. W. Sedar ◽  
G. H. Bresnick
Keyword(s):  
Lactic Acid ◽  
Chromic Acid ◽  
Periodic Acid ◽  
Müller Cell ◽  
External Limiting Membrane ◽  
Electron Microscope Level ◽  
Reactive Process ◽  
Inner Limiting Membrane ◽  
Muller Cell ◽  
And Migration

After experimetnal damage to the retina with a variety of procedures Müller cell hypertrophy and migration occurs. According to Kuwabara and others the reactive process in these injuries is evidenced by a marked increase in amount of glycogen in the Müller cells. These cells were considered originally supporting elements with fiber processes extending throughout the retina from inner limiting membrane to external limiting membrane, but are known now to have high lactic acid dehydrogenase activity and the ability to synthesize glycogen. Since the periodic acid-chromic acid-silver methenamine technique was shown to demonstrate glycogen at the electron microscope level, it was selected to react with glycogen in the fine processes of the Müller cell that ramify among the neural elements in various layers of the retina and demarcate these cells cytologically. The Rhesus monkey was chosen as an example of a well vascularized retina and the rabbit as an example of a avascular retina to explore the possibilities of the technique.

Sign in / Sign up

Export Citation Format

Share Document