Do endometrial natural killer and regulatory T cells differ in infertile and clinical pregnancy patients? An analysis in patients undergoing frozen embryo transfer cycles

2021 ◽  
Author(s):  
May‐Tal Sauerbrun‐Cutler ◽  
Warren J. Huber ◽  
Paula M. Krueger ◽  
C. James Sung ◽  
Phinnara Has ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Natural Killer ◽  
Embryo Transfer ◽  
Clinical Pregnancy ◽  
Frozen Embryo Transfer

DO ENDOMETRIAL NATURAL KILLER AND REGULATORY T CELLS DIFFER IN INFERTILE AND CLINICAL PREGNANCY PATIENTS? AN ANALYSIS IN PATIENTS UNDERGOING FROZEN EMBRYO TRANSFER CYCLES

2020 ◽  
Vol 114 (3) ◽  
pp. e104-e105
Author(s):  
May-Tal Sauerbrun-Cutler ◽  
Warren J. Huber ◽  
Paula M. Krueger ◽  
James Sung ◽  
Phinnara Has ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Natural Killer ◽  
Embryo Transfer ◽  
Clinical Pregnancy ◽  
Frozen Embryo Transfer

scholarly journals Should rescue ICSI be re-evaluated considering the deferred transfer of cryopreserved embryos in in-vitro fertilization cycles? A systematic review and meta-analysis

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Alessio Paffoni ◽  
Marco Reschini ◽  
Valerio Pisaturo ◽  
Cristina Guarneri ◽  
Simone Palini ◽  
...  
Keyword(s):  
In Vitro Fertilization ◽  
Pregnancy Rate ◽  
Embryo Transfer ◽  
Implantation Rate ◽  
Clinical Pregnancy ◽  
Frozen Embryo Transfer ◽  
Fertilization Failure ◽  
Vitro Fertilization ◽  
Rescue Icsi

Abstract Background Total fertilization failure represents a particularly frustrating condition for couples undergoing in vitro fertilization. With the aim of reducing the occurrence of total fertilization failure, intracytoplasmic sperm injection (ICSI) has become the first choice over conventional in vitro fertilization (IVF) procedures although evidence of improved results is still debated and its use in couples without male factor infertility is not recommended. Among the strategies potentially useful to promote the use of conventional IVF, we herein call attention to the late rescue ICSI, which consists in performing ICSI after 18–24 h from conventional insemination on oocytes that show no signs of fertilization. This treatment has however been reported to be associated with a low success rate until recent observations that embryos derived from late rescue ICSI may be transferred after cryopreservation in a frozen-thawed cycle with improved results. The aim of the present study was to assess whether frozen embryos deriving from rescue ICSI performed about 24 h after conventional IVF may represent a valuable option for couples experiencing fertilization failure. Methods A systematic review on the efficacy of late rescue ICSI was performed consulting PUBMED and EMBASE. Results Including twenty-two original studies, we showed that clinical pregnancy rate per embryo transfer and implantation rate obtainable with fresh embryo transfers after rescue ICSI are not satisfactory being equal to 10 and 5%, respectively. The transfer of cryopreserved rescue ICSI embryos seems to offer a substantial improvement of success rates, with pregnancy rate per embryo transfer and implantation rate equal to 36 and 18%, respectively. Coupling rescue ICSI with frozen embryo transfer may ameliorate the clinical pregnancy rate for embryo transfer with an Odds Ratio = 4.7 (95% CI:2.6–8.6). Conclusion Results of the present review support the idea that r-ICSI coupled with frozen embryo transfer may overcome most of the technical and biological issues associated with fresh transfer after late r-ICSI, thus possibly representing an efficient procedure for couples experiencing fertilization failure following conventional IVF cycles. Trial registration Prospero registration ID: CRD42021239026.

A divergent response of innate regulatory T-cells to sepsis in humans: Circulating invariant natural killer T-cells are preserved

2014 ◽  
Vol 75 (3) ◽  
pp. 277-282 ◽  
Author(s):  
Daithi S. Heffernan ◽  
Sean F. Monaghan ◽  
Chun-Shiang Chung ◽  
William G. Cioffi ◽  
Stefan Gravenstein ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Natural Killer ◽  
Natural Killer T Cells ◽  
Killer T Cells ◽  
Invariant Natural Killer ◽  
Divergent Response ◽  
Natural Killer T

scholarly journals Suppression of natural killer cell-mediated bone marrow cell rejection by CD4+CD25+ regulatory T cells

2006 ◽  
Vol 103 (14) ◽  
pp. 5460-5465 ◽  
Author(s):  
I. Barao ◽  
A. M. Hanash ◽  
W. Hallett ◽  
L. A. Welniak ◽  
K. Sun ◽  
...  
Keyword(s):  
Bone Marrow ◽  
T Cells ◽  
Natural Killer Cell ◽  
Regulatory T Cells ◽  
Natural Killer ◽  
Bone Marrow Cell ◽  
Marrow Cell ◽  
Killer Cell

Activation of natural killer T cells inhibits the development of induced regulatory T cells via IFNγ

2011 ◽  
Vol 411 (3) ◽  
pp. 599-606 ◽  
Author(s):  
Kyu Heon Oh ◽  
Changjin Lee ◽  
Sung Won Lee ◽  
Sung H. Jeon ◽  
Se-Ho Park ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Natural Killer ◽  
Natural Killer T Cells ◽  
Killer T Cells ◽  
Natural Killer T

scholarly journals The immunosuppressive tumour network: myeloid-derived suppressor cells, regulatory T cells and natural killer T cells

Immunology ◽  
2013 ◽  
Vol 138 (2) ◽  
pp. 105-115 ◽  
Author(s):  
Dennis Lindau ◽  
Paul Gielen ◽  
Michiel Kroesen ◽  
Pieter Wesseling ◽  
Gosse J. Adema
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Natural Killer ◽  
Suppressor Cells ◽  
Natural Killer T Cells ◽  
Myeloid Derived Suppressor Cells ◽  
Killer T Cells ◽  
Natural Killer T
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