Anti‐sperm antibodies and reproductive failures

As a result of vasectomy, spermatozoa are confined to the epididymis and vas deferens, where they degenerate, releasing antigens that enter the circulation or are engulfed by macrophages. Multiple antigens of the sperm can elicit production of autoantibodies; circulating anti-sperm antibodies are found in a large percentage of vasectomized men, indicating the immunogenicity of the sperm. The increased prevalence of macrophages in the liomen of the rhesus monkey testicular efferent ducts after vasectomy led to further study of this region. Frozen sections were used for evaluation of immunopathological status by fluorescence microscopy with fluorescein-conjugated antibody. Subsequent granular deposits of immune complexes were revealed by positive immunofluorescence staining for complement. The immune complex deposition in the basement membrane surrounding the efferent ducts implies that this region is involved in antigen leakage (Fig. 1).

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Capturing spermatozoa for STR analysis of sexual assault cases using anti-sperm antibodies

Forensic Science International Genetics Supplement Series ◽

10.1016/j.fsigss.2019.10.146 ◽

2019 ◽

Vol 7 (1) ◽

pp. 707-710

Author(s):

Dina Alsalafi ◽

William Goodwin

Keyword(s):

Sexual Assault ◽

Str Analysis ◽

Sperm Antibodies

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In vitro production of human anti-sperm antibodies: effect of an oligoclonal antibody (F6) on sperm-egg interaction

Journal of Reproductive Immunology ◽

10.1016/0165-0378(95)00939-i ◽

1995 ◽

Vol 29 (2) ◽

pp. 135-147 ◽

Cited By ~ 1

Author(s):

F.M. Fusi ◽

F. Besuschio ◽

L. De Santis ◽

I. Lorenzetti ◽

A. Ferrari

Keyword(s):

In Vitro Production ◽

Sperm Antibodies ◽

Vitro Production

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Relationship of Sperm Antibodies in Women and Men to Human In Vitro Fertilization, Cleavage, and Pregnancy Rate

American Journal of Reproductive Immunology ◽

10.1111/j.1600-0897.1993.tb00611.x ◽

1993 ◽

Vol 30 (2-3) ◽

pp. 108-112 ◽

Cited By ~ 19

Author(s):

TAI-HO CHANG ◽

MING H. JIH ◽

TSUNG-CHIEH J. WU

Keyword(s):

In Vitro Fertilization ◽

Pregnancy Rate ◽

Vitro Fertilization ◽

Human In Vitro Fertilization ◽

Sperm Antibodies ◽

Relationship Of

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SPERM ACROSOME STATUS AND SPERM ANTIBODIES IN INFERTILITY

The Journal of Urology ◽

10.1097/00005392-199805000-00040 ◽

1998 ◽

Vol 159 (5) ◽

pp. 1554-1558 ◽

Cited By ~ 11

Author(s):

STEVEN HARRISON ◽

GERALD HULL ◽

SUBBI PILLAI

Keyword(s):

Sperm Antibodies ◽

Sperm Acrosome

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Autoantibodies and common idiotypes in men and women with sperm antibodies

American Journal of Obstetrics and Gynecology ◽

10.1016/0002-9378(88)90037-3 ◽

1988 ◽

Vol 158 (3) ◽

pp. 596-603 ◽

Cited By ~ 23

Author(s):

Albert El-Roeiy ◽

Guido Valesini ◽

Jan Friberg ◽

Yehuda Shoenfeld ◽

Ronnald C. Kennedy ◽

...

Keyword(s):

Men And Women ◽

Sperm Antibodies

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Cytotoxic sperm antibodies inhibit sperm penetration of zona-free hamster eggs**Publication 750 from the Department of Basic and Clinical Immunology and Microbiology, Medical University of South Carolina.††Supported by United States Public Health Service grants National Institutes of Health HD-14365 and Research Career Development Award HD-00450 and Intramural Research grant CR-20 (S. M.).

Fertility and Sterility ◽

10.1016/s0015-0282(16)49285-x ◽

1986 ◽

Vol 45 (4) ◽

pp. 542-549 ◽

Cited By ~ 22

Author(s):

Azmy Abdel-Latif ◽

Subbi Mathur ◽

Philip F. Rust ◽

Christopher M. Fredericks ◽

Hassan Abdel-Aal ◽

...

Keyword(s):

South Carolina ◽

United States Public Health ◽

National Institutes Of Health ◽

Research Career ◽

University Of South Carolina ◽

Sperm Penetration ◽

Sperm Antibodies ◽

Medical University ◽

Career Development Award ◽

Research Grant

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Engineering Highly Homogenous Tetravalent IgGs with Enhanced Sperm Agglutination Potency

10.1101/2020.04.27.064865 ◽

2020 ◽

Author(s):

Bhawana Shrestha ◽

Alison Schaefer ◽

Elizabeth C. Chavez ◽

Alexander J. Kopp ◽

Timothy M. Jacobs ◽

...

Keyword(s):

Side Effects ◽

Hormonal Contraception ◽

Infertile Woman ◽

Exogenous Hormones ◽

Infertile Women ◽

Unintended Pregnancies ◽

Naturally Occurring ◽

Promising Strategy ◽

Sperm Antibodies

AbstractMillions of women avoid using available contraceptives and risk unintended pregnancies every year, due to perceived and/or real side-effects associated with the use of exogenous hormones. Naturally occurring anti-sperm antibodies can prevent fertilization in immune infertile women by limiting sperm permeation through mucus, particularly multivalent antibodies such as sIgA that offers robust agglutination potencies. Unfortunately, sIgA remains challenging to produce in large quantities and easily aggregates. Here, we designed two tetravalent anti-sperm IgGs with a Fab domain previously isolated from an immune infertile woman. Both constructs possess at least 4-fold greater agglutination potency and induced much more rapid sperm agglutination than the parent IgG while exhibiting comparable production yields and identical thermostability as the parent IgG. These tetravalent IgGs offer promise for non-hormonal contraception and underscore the multimerization of IgG as a promising strategy to improve existing mAb therapeutics.

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