Testicular inflammation and infertility: Could chlamydial infections be contributing?

2020 ◽  
Vol 84 (3) ◽  
Author(s):  
Emily R. Bryan ◽  
Jay Kim ◽  
Kenneth W. Beagley ◽  
Alison J. Carey
Keyword(s):  
Testicular Inflammation ◽  
Chlamydial Infections

Test-of-Cure for Asymptomatic Genital Chlamydial Infections in Women

1992 ◽  
Vol 19 (3) ◽  
pp. 133-136 ◽  
Author(s):  
A. SCHITZ HJALMAR ◽  
A. CSÁNGÓ PÉTER
Keyword(s):  
Chlamydial Infections

scholarly journals Human Chlamydial Infections

1980 ◽  
Vol 56 (1) ◽  
pp. 58-58 ◽  
Author(s):  
J D Oriel
Keyword(s):  
Chlamydial Infections

A multidistrict audit on the management of Chlam ydia trachomatis in genitourinary medicine clinics in Yorkshire

1997 ◽  
Vol 8 (12) ◽  
pp. 792-795 ◽  
Author(s):  
Eric F Monteiro ◽  
Janet Harris ◽  
Paul Gilliatt
Keyword(s):  
Teaching Hospital ◽  
Contact Tracing ◽  
General Hospitals ◽  
Male And Female ◽  
Female Patients ◽  
Genitourinary Medicine ◽  
Chlamydial Infections

Summary: Nine genitourinary clinics (one teaching hospital and 8 district general hospitals) within the Yorkshire Deanery audited the management of uncomplicated genital chlamydial infections in male and female patients attending between January and December 1995. Standards set included: 100% of chlamydia-positive patients to be treated within 2 weeks of diagnosis; 100% of patients to return for test of cure within one month of treatment; 100% of patients to be referred for contact tracing. Four hundred and thirty-six of a total 1356 cases were audited. Eighty-nine per cent received treatment within 2 weeks; 64% returned for a test of cure within one month; 93% were referred for contact tracing. Changes in practice and a regionwide multidisciplinary audit initiative resulted from the study.

scholarly journals Pathway-Wide Genetic Risks in Chlamydial Infections Overlap between Tissue Tropisms: A Genome-Wide Association Scan

2018 ◽  
Vol 2018 ◽  
pp. 1-9
Author(s):  
Chrissy H. Roberts ◽  
Sander Ouburg ◽  
Mark D. Preston ◽  
Henry J. C. de Vries ◽  
Martin J. Holland ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Chlamydia Trachomatis ◽  
Mitotic Cell ◽  
Genome Wide Association ◽  
Serological Response ◽  
Transmitted Infection ◽  
Genome Wide ◽  
A Genome ◽  
Tissue Tropisms ◽  
Chlamydial Infections

Chlamydia trachomatis is the most commonly diagnosed bacterial sexually transmitted infection and can lead to tubal factor infertility, a disease characterised by fibrosis of the fallopian tubes. Genetic polymorphisms in molecular pathways involving G protein-coupled receptor signalling, the Akt/PI3K cascade, the mitotic cell cycle, and immune response have been identified in association with the development of trachomatous scarring, an ocular form of chlamydia-related fibrotic pathology. In this case-control study, we performed genome-wide association and pathways-based analysis in a sample of 71 Dutch women who attended an STI clinic who were seropositive for Chlamydia trachomatis antibodies and 169 high-risk Dutch women who sought similar health services but who were seronegative. We identified two regions of within-gene SNP association with Chlamydia trachomatis serological response and found that GPCR signalling and cell cycle pathways were also associated with the trait. These pathway-level associations appear to be common to immunological sequelae of chlamydial infections in both ocular and urogenital tropisms. These pathways may be central mediators of human refractoriness to chlamydial diseases.

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