scholarly journals The role of RORγt at maternal‐fetal interface during murine pregnancy

2020 ◽  
Vol 84 (2) ◽  
Author(s):  
Yan Li ◽  
Gladys E. Lopez ◽  
Payton N. Lindner ◽  
Luke Parrella ◽  
Mariah Larson ◽  
...  
Keyword(s):  
Murine Pregnancy ◽  
Maternal Fetal Interface

scholarly journals The novel role of Hippo-YAP/TAZ in immunity at the mammalian maternal-fetal interface: Opportunities, challenges

2020 ◽  
Vol 126 ◽  
pp. 110061 ◽  
Author(s):  
Zengshu Huang ◽  
Jing Zhou ◽  
Wing Ting Leung ◽  
Hans Jürgen Gober ◽  
Xinyao Pan ◽  
...  
Keyword(s):  
The Novel ◽  
Maternal Fetal Interface

scholarly journals The Dual Role of HLA-C in Tolerance and Immunity at the Maternal-Fetal Interface

2019 ◽  
Vol 10 ◽  
Author(s):  
Henrieta Papúchová ◽  
Torsten B. Meissner ◽  
Qin Li ◽  
Jack L. Strominger ◽  
Tamara Tilburgs
Keyword(s):  
Dual Role ◽  
Maternal Fetal Interface

Sterile inflammation at the maternal-fetal interface: role of HMGB1

Placenta ◽  
2017 ◽  
Vol 57 ◽  
pp. 255-256
Author(s):  
Ines Boufaied ◽  
Julia Palacios ◽  
Virginie Gaudreault ◽  
Sylvie Girard
Keyword(s):  
Sterile Inflammation ◽  
Maternal Fetal Interface

Role of GnRH–GnRH receptor signaling at the maternal-fetal interface

2010 ◽  
Vol 94 (7) ◽  
pp. 2680-2687 ◽  
Author(s):  
Hee Joong Lee ◽  
Victoria V. Snegovskikh ◽  
Joong Shin Park ◽  
Nastaran Foyouzi ◽  
Ku Taek Han ◽  
...  
Keyword(s):  
Gnrh Receptor ◽  
Receptor Signaling ◽  
Maternal Fetal Interface

scholarly journals A proteomic atlas of ligand-receptor interactions at the ovine maternal-fetal interface reveals the role of histone lactylation in uterine remodeling

2021 ◽  
Author(s):  
Qianying Yang ◽  
Juan Liu ◽  
Yue Wang ◽  
Wei Zhao ◽  
Wenjing Wang ◽  
...  
Keyword(s):  
Embryo Implantation ◽  
Redox Homeostasis ◽  
Integrated Analysis ◽  
Physical Interaction ◽  
Uterine Receptivity ◽  
In Vivo Models ◽  
Receptor Complexes ◽  
Maternal Fetal Interface

Abstract Well-orchestrated maternal-fetal crosstalk occurs via secreted ligands, interacting receptors, and coupled intracellular pathways between the conceptus and endometrium, and is essential for successful embryo implantation. However, previous studies mostly focus on either the conceptus or the endometrium in isolation. The lack of integrated analysis impedes our understanding of early maternal-fetal crosstalk. Herein, focusing on ligand–receptor complexes and coupled pathways at the maternal-fetal interface in sheep, we provide the first comprehensive proteomic map of ligand-receptor pathway cascades essential for embryo implantation. We demonstrate that these cascades are associated with cell adhesion and invasion, redox homeostasis, and the immune response. Candidate interactions and their physiological roles were further validated by functional experiments. We reveal the physical interaction of albumin and claudin 4 and their roles in facilitating embryo attachment to endometrium. We also demonstrate a novel function of enhanced conceptus glycolysis in remodeling uterine receptivity by inducing endometrial histone lactylation, a newly identified histone modification. Results from in vitro and in vivo models supported the essential role of lactate in inducing endometrial H3K18 lactylation and in regulating redox homeostasis and apoptotic balance to ensure successful implantation. By reconstructing a map of potential ligand-receptor pathway cascades at the maternal-fetal interface, our study presents new concepts for understanding molecular and cellular mechanisms that fine-tune conceptus-endometrium crosstalk during implantation. This provides more direct and accurate insights for developing potential clinical intervention strategies to improve pregnancy outcomes following both natural and assisted conception.

scholarly journals The role of extracellular matrix in normal and pathological pregnancy: Future applications of microphysiological systems in reproductive medicine

2020 ◽  
Vol 245 (13) ◽  
pp. 1163-1174
Author(s):  
Blakely B O’Connor ◽  
Benjamin D Pope ◽  
Michael M Peters ◽  
Carrie Ris-Stalpers ◽  
Kevin K Parker
Keyword(s):  
Extracellular Matrix ◽  
Cellular Adhesion ◽  
Migration And Invasion ◽  
Matrix Remodeling ◽  
Healthy Pregnancy ◽  
Microphysiological Systems ◽  
Maternal Fetal Interface

Remodeling of extracellular matrix in the womb facilitates the dramatic morphogenesis of maternal and placental tissues necessary to support fetal development. In addition to providing a scaffold to support tissue structure, extracellular matrix influences pregnancy outcomes by facilitating communication between cells and their microenvironment to regulate cellular adhesion, migration, and invasion. By reviewing the functions of extracellular matrix during key developmental milestones, including fertilization, embryo implantation, placental invasion, uterine growth, and labor, we illustrate the importance of extracellular matrix during healthy pregnancy and development. We also discuss how maladaptive matrix expression contributes to infertility and obstetric diseases such as implantation failure, preeclampsia, placenta accreta, and preterm birth. Recently, advances in engineering the biotic–abiotic interface have potentiated the development of microphysiological systems, known as organs-on-chips, to represent human physiological and pathophysiological conditions in vitro. These technologies may offer new opportunities to study human fertility and provide a more granular understanding of the role of adaptive and maladaptive remodeling of the extracellular matrix during pregnancy. Impact statement Extracellular matrix in the womb regulates the initiation, progression, and completion of a healthy pregnancy. The composition and physical properties of extracellular matrix in the uterus and at the maternal–fetal interface are remodeled at each gestational stage, while maladaptive matrix remodeling results in obstetric disease. As in vitro models of uterine and placental tissues, including micro-and milli-scale versions of these organs on chips, are developed to overcome the inherent limitations of studying human development in vivo, we can isolate the influence of cellular and extracellular components in healthy and pathological pregnancies. By understanding and recreating key aspects of the extracellular microenvironment at the maternal–fetal interface, we can engineer microphysiological systems to improve assisted reproduction, obstetric disease treatment, and prenatal drug safety.

scholarly journals Lung microbiota dysbiosis and the implications of SARS-CoV-2 infection in pregnancy

2021 ◽  
Vol 8 ◽  
pp. 204993612110324
Author(s):  
Henry C. Ezechukwu ◽  
Cornelius A. Diya ◽  
Ifunanya J. Egoh ◽  
Mayowa J. Abiodun ◽  
John-Ugwuanya A. Grace ◽  
...  
Keyword(s):  
Respiratory Diseases ◽  
Opportunistic Infections ◽  
Angiotensin Converting Enzyme 2 ◽  
Receptor Proteins ◽  
Mucosal Lining ◽  
Maternal Fetal Transmission ◽  
Entry Receptor ◽  
Pregnant Mothers ◽  
Maternal Fetal Interface

There are a great number of beneficial commensal microorganisms constitutively colonizing the mucosal lining of the lungs. Alterations in the microbiota profile have been associated with several respiratory diseases such as pneumonia and allergies. Lung microbiota dysbiosis might play an important role in the pathogenic mechanisms of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) as well as elicit other opportunistic infections associated with coronavirus disease 2019 (COVID-19). With its increasing prevalence and morbidity, SARS-CoV-2 infection in pregnant mothers is inevitable. Recent evidence shows that angiotensin-converting enzyme 2 (ACE2) and transmembrane protease serine 2 (TMPRSS2) act as an entry receptor and viral spike priming protein, respectively, for SARS-CoV-2 infection. These receptor proteins are highly expressed in the maternal-fetal interface, including the placental trophoblast, suggesting the possibility of maternal–fetal transmission. In this review, we discuss the role of lung microbiota dysbiosis in respiratory diseases, with an emphasis on COVID-19 and the possible implications of SARS-CoV-2 infection on pregnancy outcome and neonatal health.

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