Myeloid‐derived suppressor cells depletion may cause pregnancy loss via upregulating the cytotoxicity of decidual natural killer cells

2019 ◽  
Vol 81 (4) ◽  
pp. e13099 ◽  
Author(s):  
Jiabin Ren ◽  
Weihong Zeng ◽  
Fuju Tian ◽  
Siming Zhang ◽  
Fan Wu ◽  
...  
Keyword(s):  
Natural Killer Cells ◽  
Natural Killer ◽  
Pregnancy Loss ◽  
Suppressor Cells ◽  
Myeloid Derived Suppressor Cells ◽  
Killer Cells ◽  
Decidual Natural Killer Cells

Tumor Microenvironmental Conversion of Natural Killer Cells into Myeloid-Derived Suppressor Cells

2013 ◽  
Vol 73 (18) ◽  
pp. 5669-5681 ◽  
Author(s):  
Young-Jun Park ◽  
Boyeong Song ◽  
Yun-Sun Kim ◽  
Eun-Kyung Kim ◽  
Jung-Mi Lee ◽  
...  
Keyword(s):  
Natural Killer Cells ◽  
Natural Killer ◽  
Suppressor Cells ◽  
Myeloid Derived Suppressor Cells ◽  
Killer Cells

scholarly journals Myeloid derived suppressor cells inhibit natural killer cells in patients with hepatocellular carcinoma via the NKp30 receptor

Hepatology ◽  
2009 ◽  
Vol 50 (3) ◽  
pp. 799-807 ◽  
Author(s):  
Bastian Hoechst ◽  
Torsten Voigtlaender ◽  
Lars Ormandy ◽  
Jaba Gamrekelashvili ◽  
Fei Zhao ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Natural Killer Cells ◽  
Natural Killer ◽  
Suppressor Cells ◽  
Myeloid Derived Suppressor Cells ◽  
Killer Cells

scholarly journals Myeloid-derived suppressor cells at diagnosis may discriminate between benign and malignant ovarian tumors

2019 ◽  
Vol 29 (9) ◽  
pp. 1381-1388 ◽  
Author(s):  
An Coosemans ◽  
Thaïs Baert ◽  
Jolien Ceusters ◽  
Pieter Busschaert ◽  
Chiara Landolfo ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
T Cells ◽  
Immune System ◽  
Natural Killer Cells ◽  
Regulatory T Cells ◽  
Natural Killer ◽  
Immune Cells ◽  
Suppressor Cells ◽  
Myeloid Derived Suppressor Cells ◽  
Killer Cells

BackgroundThe behavior of the immune system as a driver in the progression of ovarian cancer has barely been studied. Our knowledge is mainly limited to the intra-tumoral adaptive immune system. Because of the widespread metastases of ovarian cancer, an assessment of the circulating immune system seems more accurate.To demonstrate the presence of immune cells in blood samples of patients with ovarian neoplasms.MethodsIn this exploratory prospective cohort study, peripheral blood mononuclear cells were collected at diagnosis from 143 women, including 62 patients with benign cysts, 13 with borderline tumor, 41 with invasive ovarian cancer, and 27 age-matched healthy controls. Immune profile analyses, based on the presence of CD4 (cluster of differentiation), CD8, natural killer cells, myeloid-derived suppressor cells, and regulatory T cells, were performed by fluorescence activated cell sorting.ResultsIn a multivariable analysis, six immune cells (activated regulatory T cells, natural killer cells, myeloid-derived suppressor cells, monocytic myeloid-derived suppressor cells, exhausted monocytic myeloid-derived suppressor cells, and total myeloid cells) were selected as independent predictors of malignancy, with an optimism-corrected area under the receiver operating characteristic curve (AUC) of 0.858. In contrast, a profile based on CD8 and regulatory T cells, the current standard in ovarian cancer immunology, resulted in an AUC of 0.639.ConclusionsOur immune profile in blood suggests an involvement of innate immunosuppression driven by myeloid-derived suppressor cells in the development of ovarian cancer. This finding could contribute to clinical management of patients and in selection of immunotherapy.

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