In response to Manuscript AJRI 01-18-016 entitled “Regulatory T cells, natural killer cells and obesity in patients with gestational diabetes mellitus”-Kawada T

2018 ◽  
Vol 79 (4) ◽  
pp. e12830
Author(s):  
Thalita Frutuoso Lobo ◽  
Camila de Moraes Borges ◽  
Rosiane Mattar ◽  
Caio Perez Gomes ◽  
Ana Geisa Santos de Ângelo ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
T Cells ◽  
Natural Killer Cells ◽  
Regulatory T Cells ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Natural Killer ◽  
Killer Cells

The role of regulatory T cells in the control of natural killer cells: relevance during tumor progression

2006 ◽  
Vol 214 (1) ◽  
pp. 229-238 ◽  
Author(s):  
Francois Ghiringhelli ◽  
Cédric Ménard ◽  
Francois Martin ◽  
Laurence Zitvogel
Keyword(s):  
T Cells ◽  
Natural Killer Cells ◽  
Regulatory T Cells ◽  
Tumor Progression ◽  
Natural Killer ◽  
Killer Cells

scholarly journals Foxp3+ Regulatory T Cells and Natural Killer Cells Distinctly Infiltrate Primary Tumors and Draining Lymph Nodes in Pulmonary Adenocarcinoma

2011 ◽  
Vol 6 (3) ◽  
pp. 432-438 ◽  
Author(s):  
Thomas Schneider ◽  
Silvia Kimpfler ◽  
Arne Warth ◽  
Philipp A. Schnabel ◽  
Hendrik Dienemann ◽  
...  
Keyword(s):  
T Cells ◽  
Natural Killer Cells ◽  
Regulatory T Cells ◽  
Lymph Nodes ◽  
Natural Killer ◽  
Pulmonary Adenocarcinoma ◽  
Killer Cells ◽  
Primary Tumors ◽  
Draining Lymph Nodes

scholarly journals Metabolic Remodeling in Glioma Immune Microenvironment: Intercellular Interactions Distinct From Peripheral Tumors

2021 ◽  
Vol 9 ◽  
Author(s):  
Runze Qiu ◽  
Yue Zhong ◽  
Qingquan Li ◽  
Yingbin Li ◽  
Hongwei Fan
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
Tumor Microenvironment ◽  
Natural Killer Cells ◽  
T Lymphocytes ◽  
Regulatory T Cells ◽  
Natural Killer ◽  
Cytotoxic T Lymphocytes ◽  
Glioma Cells ◽  
Killer Cells

During metabolic reprogramming, glioma cells and their initiating cells efficiently utilized carbohydrates, lipids and amino acids in the hypoxic lesions, which not only ensured sufficient energy for rapid growth and improved the migration to normal brain tissues, but also altered the role of immune cells in tumor microenvironment. Glioma cells secreted interferential metabolites or depriving nutrients to injure the tumor recognition, phagocytosis and lysis of glioma-associated microglia/macrophages (GAMs), cytotoxic T lymphocytes, natural killer cells and dendritic cells, promoted the expansion and infiltration of immunosuppressive regulatory T cells and myeloid-derived suppressor cells, and conferred immune silencing phenotypes on GAMs and dendritic cells. The overexpressed metabolic enzymes also increased the secretion of chemokines to attract neutrophils, regulatory T cells, GAMs, and dendritic cells, while weakening the recruitment of cytotoxic T lymphocytes and natural killer cells, which activated anti-inflammatory and tolerant mechanisms and hindered anti-tumor responses. Therefore, brain-targeted metabolic therapy may improve glioma immunity. This review will clarify the metabolic properties of glioma cells and their interactions with tumor microenvironment immunity, and discuss the application strategies of metabolic therapy in glioma immune silence and escape.

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