Maternal history of recurrent pregnancy loss is associated with increased risk for long-term pediatric gastrointestinal morbidity in the offspring

2017 ◽  
Vol 79 (2) ◽  
pp. e12799 ◽  
Author(s):  
Yael Lichtman ◽  
Eyal Sheiner ◽  
Tamar Wainstock ◽  
Idit Segal ◽  
Daniella Landau ◽  
...  
Keyword(s):  
Pregnancy Loss ◽  
Recurrent Pregnancy Loss ◽  
Maternal History ◽  
Increased Risk ◽  
History Of

scholarly journals 593: Maternal history of recurrent pregnancy loss and long-term risk of thromboembolic events

2019 ◽  
Vol 220 (1) ◽  
pp. S393-S394
Author(s):  
Polina Schwarzman ◽  
Dorit Paz ◽  
Asnat Walfisch ◽  
Ruslan Sergienko ◽  
Eyal Sheiner
Keyword(s):  
Pregnancy Loss ◽  
Recurrent Pregnancy Loss ◽  
Thromboembolic Events ◽  
Maternal History ◽  
History Of

Maternal history of recurrent pregnancy loss increases the risk for long‐term pediatric respiratory morbidity of the offspring

2020 ◽  
Vol 55 (7) ◽  
pp. 1765-1770
Author(s):  
Sharon Davidesko ◽  
Tamar Wainstock ◽  
Eyal Sheiner ◽  
Daniella Landau ◽  
Asnat Walfisch
Keyword(s):  
Pregnancy Loss ◽  
Recurrent Pregnancy Loss ◽  
Respiratory Morbidity ◽  
Maternal History ◽  
History Of

Maternal history of recurrent pregnancy loss and long-term risk of thromboembolic events

2020 ◽  
Vol 138 ◽  
pp. 103084 ◽  
Author(s):  
Polina Schwarzman ◽  
Dorit Paz Levy ◽  
Asnat Walfisch ◽  
Ruslan Sergienko ◽  
Eli H. Bernstein ◽  
...  
Keyword(s):  
Pregnancy Loss ◽  
Recurrent Pregnancy Loss ◽  
Thromboembolic Events ◽  
Maternal History ◽  
History Of

scholarly journals Investigating Association of rs5918 Human Platelets Antigen 1 and rs1800790 Fibrinogen β Chain as Critical Players with Recurrent Pregnancy Loss

2018 ◽  
Vol 6 (4) ◽  
pp. 98 ◽  
Author(s):  
Fatemeh Karami ◽  
Maliheh Askari ◽  
Mohammad Modarressi
Keyword(s):  
Pregnancy Loss ◽  
Recurrent Pregnancy Loss ◽  
Human Platelets ◽  
P Value ◽  
Increased Risk ◽  
History Of ◽  
Polymerase Chain ◽  
Β Chain ◽  
Larger Sample

Thrombophilia gene variants have been shown to be associated with higher risk of recurrent pregnancy loss (RPL). Due to the role of human platelets antigen 1 (HPA-1) and fibrinogen β chain (FGB) as critical players in the coagulation process, their most important variants including rs5918 T > C and rs1800790 G > A were selected to be studied in women affected by RPL. Three milliliters of peripheral blood were drawn from 110 women with history of at least two consecutive spontaneous abortion and 110 healthy women controls. rs5918 T > C and rs1800790 G > A of HPA-1 and FGB genes, respectively, were selected to be analyzed through polymerase chain reaction-restriction fragment length polymorphism (PCR_RFLP) following DNA isolation using QIAamp DNA Blood Mini Kit. Heterozygote genotype (TC) of HPA-1 gene rs5918 polymorphism was significantly associated with risk of RPL (p-value = 0.02). Although, rs1800790 G > A of FGB gene was not associated with RPL, its combination with rs5918 polymorphism was associated with increased risk of RPL. Owing to the critical roles of FGB and HPA-1 genes in coagulation, and thrombosis and several confinements on the meaningful association between the combination of those polymorphism with risk of RPL, including them in the thrombophilia panel may increase detection rate of hereditary thrombophilia patients. However, further studies with larger sample sizes are required to shed light on the exact role of the studied gene polymorphism, especially rs1800790 G > A of FGB gene variant in pathogenesis of RPL.

scholarly journals Evaluation of factor VIII value in normal women and whom encountered recurrent pregnancy loss: is there any significant difference?

2020 ◽  
Vol 9 (3) ◽  
pp. 1034
Author(s):  
Douaa Al Rez ◽  
Hasan Naser Eldine ◽  
Marwan Alhalabi
Keyword(s):  
Factor Viii ◽  
Pregnancy Loss ◽  
Recurrent Pregnancy Loss ◽  
Fetal Loss ◽  
Control Group ◽  
Increased Risk ◽  
Significant Difference ◽  
History Of ◽  
Normal Women ◽  
High Level

Background: Recurrent pregnancy loss (RPL) is a serious problem on the women, it defined as two or more consecutive pregnancy losses before the fetus has reached birth. The aim of this study is to evaluate the association between the elevation in the factor VIII and RPL. Because women who have thrombophilia have increased risk of fetal loss in most studies.Methods: A total 72 women were recruited in this case control study. They divided into two groups: the RPL group included 41 women with a history of recurrent pregnancy loss and the control group included 31 healthy women, who had at least one successful pregnancy and none of them had a history of fetal loss or complicated pregnancy.Results: A majority of the patients of this study didn't have a high level of factor VIII, 9 of 41 (22%) patients of RPL group in comparison with 21 of 32 (65,6%) of control group, that suffer from the increase rate of FVIII, this means that factor VIII doesn't effect on RPL.Conclusions: The present study showed that the serum elevation in the factor VIII is not significantly associated with RPL.

scholarly journals Maternal recurrent pregnancy loss is associated with an increased risk for long‐term neurological morbidity in offspring

2018 ◽  
Vol 61 (1) ◽  
pp. 91-97 ◽  
Author(s):  
Dorit Paz Levy ◽  
Tamar Wainstock ◽  
Eyal Sheiner ◽  
Ruslan Sergienko ◽  
Daniella Landau ◽  
...  
Keyword(s):  
Pregnancy Loss ◽  
Recurrent Pregnancy Loss ◽  
Increased Risk ◽  
Neurological Morbidity

Consultative Hematology: The Pregnant Patient Pregnancy Loss

Hematology ◽  
2010 ◽  
Vol 2010 (1) ◽  
pp. 166-172 ◽  
Author(s):  
Shannon M. Bates
Keyword(s):  
Antithrombotic Therapy ◽  
Pregnancy Loss ◽  
Recurrent Pregnancy Loss ◽  
Pregnant Patient ◽  
Quality Data ◽  
Successful Outcome ◽  
Pregnancy Failure ◽  
Increased Risk ◽  
History Of ◽  
Good Quality Data

Abstract The presence of antiphospholipid antibodies has been associated with an increased risk of recurrent pregnancy loss, and there is evidence to suggest that antithrombotic therapy improves the likelihood of a successful outcome in affected women. Recent studies suggest an association between hereditary thrombophilia and pregnancy loss, although a causal role remains controversial. Although the available data are limited and flawed, there is increasing use of antithrombotic therapy in thrombophilic women with a history of pregnancy failure. Given the absence of proven effective therapy in women with unexplained recurrent loss, there is also growing pressure to intervene with antithrombotics in women with no known underlying thrombophilia. This article reviews the evidence for an association between thrombophilia and recurrent pregnancy loss and the data regarding the use of antithrombotic therapy for prevention of loss—an area that remains particularly challenging because of the paucity of good quality data upon which to base clinical decisions.

Sign in / Sign up

Export Citation Format

Share Document