scholarly journals The Uterine Immune Profile May Help Women With Repeated Unexplained Embryo Implantation Failure After In Vitro Fertilization

2016 ◽  
Vol 75 (3) ◽  
pp. 388-401 ◽  
Author(s):  
Nathalie Lédée ◽  
Marie Petitbarat ◽  
Lucie Chevrier ◽  
Dominique Vitoux ◽  
Katia Vezmar ◽  
...  
Keyword(s):  
In Vitro Fertilization ◽  
Embryo Implantation ◽  
Implantation Failure ◽  
Vitro Fertilization ◽  
Immune Profile

scholarly journals MicroRNA signatures in plasma and plasma exosome during window of implantation for implantation failure following in-vitro fertilization and embryo transfer

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Hong Zeng ◽  
Yu Fu ◽  
Lang Shen ◽  
Song Quan
Keyword(s):  
In Vitro Fertilization ◽  
Embryo Transfer ◽  
Embryo Implantation ◽  
Differentially Expressed ◽  
Implantation Failure ◽  
Recurrent Implantation Failure ◽  
Vitro Fertilization ◽  
Pathway Enrichment ◽  
Consistent Direction

Abstract Background MicroRNAs (miRNAs) are small, non-coding RNAs that are dysregulated in many diseases and can act as biomarkers. Although well-studied in cancer, the role of miRNAs in embryo implantation is poorly understood. Approximately 70% of embryos fail to implant following in-vitro fertilization and embryo transfer, 10% of patients experienced recurrent implantation failure. However, there are no well-established biomarkers that can predict implantation failure. Our purpose is to investigate distinct miRNA profiles in plasma and plasma exosomes during the window of implantation between patients with failed implantation and successful implantation. Methods We select a nested case-control population of 12 patients with implantation failure or successfully clinical pregnancy using propensity score matching. RNA was extracted from plasma and plasma exosomes collected during the window of implantation (WOI). MicroRNA expression in all samples was quantified using microRNA sequencing. The intersection of differently expressed miRNAs in plasma and exosomes were further validated in the GEO dataset. Significantly altered microRNAs in both plasma and plasma exosomes were then subjected to target prediction and KEGG pathway enrichment analyses to search for key signaling pathways. WGCNA analysis was performed to identify hub miRNAs associated with implantation. Results 13 miRNAs were differentially expressed in both plasma and plasma exosomes in patients with implantation failure. Among them, miR-150-5p, miR-150-3p, miR-149-5p, and miR-146b-3p had consistent direction changes in endometrium of patients with recurrent implantation failure (RIF), miR-342-3p had consistent direction changes in blood samples of patients with RIF. Pathway enrichment analysis showed that the target genes of differentially expressed miRNAs are enriched in pathways related to embryo implantation. WGCNA analysis indicated that miR-150-5p, miR-150-3p, miR-146b-3p, and miR-342-3p are hub miRNAs. Conclusions Implantation failure is associated with distinct miRNA profiles in plasma and plasma exosomes during WOI.

Ultrasonography as a predictor of embryo implantation after in vitro fertilization: a controlled study

2003 ◽  
Vol 79 (4) ◽  
pp. 1015-1022 ◽  
Author(s):  
Bienvenido Puerto ◽  
Montserrat Creus ◽  
Francisco Carmona ◽  
Salvadora Cívico ◽  
Juan A. Vanrell ◽  
...  
Keyword(s):  
In Vitro Fertilization ◽  
Embryo Implantation ◽  
Controlled Study ◽  
Vitro Fertilization

scholarly journals Tumor necrosis factor-308 polymorphism increases the embryo implantation rate in women undergoing in vitro fertilization

2013 ◽  
Vol 28 (10) ◽  
pp. 2774-2783 ◽  
Author(s):  
F. Vialard ◽  
M. El Sirkasi ◽  
V. Tronchon ◽  
R. Boudjenah ◽  
D. Molina-gomes ◽  
...  
Keyword(s):  
In Vitro Fertilization ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Embryo Implantation ◽  
Implantation Rate ◽  
Vitro Fertilization ◽  
Embryo Implantation Rate ◽  
Necrosis Factor

Circulating autoimmune antibodies may be responsible for implantation failure in in vitro fertilization

1994 ◽  
Vol 62 (4) ◽  
pp. 802-806 ◽  
Author(s):  
Eli Geva ◽  
Yuval Yaron ◽  
Joseph B. Lessing ◽  
Israel Yovel ◽  
Nurit Vardinon ◽  
...  
Keyword(s):  
In Vitro Fertilization ◽  
Implantation Failure ◽  
Vitro Fertilization ◽  
Autoimmune Antibodies
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