Human IgG Antinuclear Antibodies Induce Pregnancy Loss in Mice by Increasing Immune Complex Deposition in Placental Tissue:In VivoStudy

2015 ◽  
Vol 74 (6) ◽  
pp. 542-552 ◽  
Author(s):  
Manuela Veglia ◽  
Silvia D'Ippolito ◽  
Riccardo Marana ◽  
Fiorella Di Nicuolo ◽  
Roberta Castellani ◽  
...  
Keyword(s):  
Immune Complex ◽  
Pregnancy Loss ◽  
Antinuclear Antibodies ◽  
Human Igg ◽  
Immune Complex Deposition ◽  
Complex Deposition

Curcumin attenuates lupus nephritis upon interaction with regulatory T cells in New Zealand Black/White mice

2012 ◽  
Vol 110 (1) ◽  
pp. 69-76 ◽  
Author(s):  
Hyojung Lee ◽  
Hyunseong Kim ◽  
Gihyun Lee ◽  
Hwan-Suck Chung ◽  
Hyunsu Bae
Keyword(s):  
New Zealand ◽  
Lupus Nephritis ◽  
Immune Complex ◽  
Serum Levels ◽  
Therapeutic Effects ◽  
Igg Antibodies ◽  
Renal Inflammation ◽  
Female Mice ◽  
Immune Complex Deposition ◽  
Complex Deposition

Curcumin has been used in Asian traditional medicine for its medicinal properties. Recent studies have demonstrated that curcumin has antioxidant, anti-tumour and anti-inflammatory activities. The aim of the present study is to investigate the effects of curcumin on established lupus nephritis (LN) in New Zealand Black/White (NZB/W) F1 female mice, in particular, its interaction with regulatory T (Treg) cells. Starting at 18 weeks of age, mice were fed a standard diet or a diet containing 1 % curcumin until the end of the study. The proteinuria level and the serum levels of IgG1, IgG2a and anti-double-stranded DNA (dsDNA) IgG antibodies were measured. Additionally, IgG immune complex deposition in the glomeruli and renal inflammation were compared between curcumin-treated mice and control mice. Curcumin decreased the proteinuria level and serum levels of IgG1, IgG2a and anti-dsDNA IgG antibodies in NZB/W F1 female mice. IgG immune complex deposition in the glomeruli was reduced in curcumin-treated mice. Furthermore, renal inflammation was also decreased after curcumin treatment. Interestingly, these therapeutic effects of curcumin disappeared after Treg depletion by anti-CD25 antibody injection. Curcumin exerted a protective effect against LN in NZB/W F1 mice. We speculate that the protective effects of curcumin in LN may involve, at least in part, its interaction with Treg cells.

Immune complex deposition in Bowman's capsule is associated with parietal podocytes

1994 ◽  
Vol 173 (1) ◽  
pp. 53-59 ◽  
Author(s):  
Ian W. Gibson ◽  
Thomas T. Downie ◽  
Ian A. R. More ◽  
George B. M. Lindop
Keyword(s):  
Immune Complex ◽  
Immune Complex Deposition ◽  
Complex Deposition ◽  
Bowman's Capsule

Immune Complex Deposition in Adult Male Sprague-Dawley Rats Chronically Immunized with GnRH

2005 ◽  
Vol 54 (5) ◽  
pp. 292-310 ◽  
Author(s):  
Louis Vargas ◽  
Richard Sewell ◽  
Aileen Marshall ◽  
Josephine Galatioto ◽  
Yun-Yen Tsong ◽  
...  
Keyword(s):  
Immune Complex ◽  
Adult Male ◽  
Sprague Dawley ◽  
Immune Complex Deposition ◽  
Sprague Dawley Rats ◽  
Complex Deposition

Diffuse Subamniotic Calcification: A Novel Pattern of Placental Calcification

2020 ◽  
Vol 23 (6) ◽  
pp. 438-442
Author(s):  
Erik W Nohr ◽  
James R Wright
Keyword(s):  
Electron Microscopy ◽  
Immune Complex ◽  
Ivig Therapy ◽  
Dystrophic Calcification ◽  
Fresh Tissue ◽  
Immune Complex Deposition ◽  
Dense Deposits ◽  
Unusual Lesion ◽  
Complex Deposition ◽  
Underlying Pathophysiology

Two primary patterns of placental calcification have been described, each with distinctive pathophysiology and clinical relevance. We report a novel pattern of diffuse subamniotic calcification. It occurred in a 25-week placenta involved by recurrent chronic histiocytic intervillositis (CHI) associated with severe intrauterine growth restriction (IUGR) and intrauterine fetal demise (IUFD). This was the mother’s third stillbirth related to CHI, despite treatment with intravenous immunoglobulin (IVIG), prednisone, low-molecular-weight heparin, and acetylsalicylic acid (ASA). On placental examination, the majority of the fetal surface was calcified. This variably formed a continuous band or dispersed calcium microparticles. Electron microscopy demonstrated associated electron dense deposits highly suggestive of immune complex deposition. CHI explains recurrent IUGR and stillbirth, but has not been associated with calcification or immune complex deposition. We hypothesize IVIG therapy may have caused immune complex deposition and subsequent dystrophic calcification, supported by its rare association with immune complex deposition disorders in the kidney. Identification of additional cases with this pattern of calcification, with additional studies on fresh tissue including immunofluorescence, electron microscopy and mass spectrometry, may aid in elucidating the underlying pathophysiology and clinical significance of this unusual lesion.

Sign in / Sign up

Export Citation Format

Share Document