Clinico‐pathological factors related to metastatic pathway in localised melanoma

2021 ◽  
Author(s):  
Nina A. Richarz ◽  
Josep Maria Hilari ◽  
Gonzalo Castillo ◽  
José Luis Manzano ◽  
Carlos Ferrándiz ◽  
...  
Keyword(s):  
Metastatic Pathway

scholarly journals The Role of Immunoglobulin Superfamily Cell Adhesion Molecules in Cancer Metastasis

2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
Chee Wai Wong ◽  
Danielle E. Dye ◽  
Deirdre R. Coombe
Keyword(s):  
Cell Adhesion ◽  
Adhesion Molecules ◽  
Cancer Progression ◽  
Cell Adhesion Molecules ◽  
Cancer Metastasis ◽  
Clinical Problem ◽  
Metastatic Lesion ◽  
Immunoglobulin Superfamily ◽  
Metastatic Pathway ◽  
Cell Cell

Metastasis is a major clinical problem and results in a poor prognosis for most cancers. The metastatic pathway describes the process by which cancer cells give rise to a metastatic lesion in a new tissue or organ. It consists of interconnecting steps all of which must be successfully completed to result in a metastasis. Cell-cell adhesion is a key aspect of many of these steps. Adhesion molecules belonging to the immunoglobulin superfamily (Ig-SF) commonly play a central role in cell-cell adhesion, and a number of these molecules have been associated with cancer progression and a metastatic phenotype. Surprisingly, the contribution of Ig-SF members to metastasis has not received the attention afforded other cell adhesion molecules (CAMs) such as the integrins. Here we examine the steps in the metastatic pathway focusing on how the Ig-SF members, melanoma cell adhesion molecule (MCAM), L1CAM, neural CAM (NCAM), leukocyte CAM (ALCAM), intercellular CAM-1 (ICAM-1) and platelet endothelial CAM-1 (PECAM-1) could play a role. Although much remains to be understood, this review aims to raise the profile of Ig-SF members in metastasis formation and prompt further research that could lead to useful clinical outcomes.

scholarly journals Accumulation of Circulating CCR7+ Natural Killer Cells Marks Melanoma Evolution and Reveals a CCL19-Dependent Metastatic Pathway

2019 ◽  
Vol 7 (5) ◽  
pp. 841-852 ◽  
Author(s):  
Costanza Maria Cristiani ◽  
Alice Turdo ◽  
Valeria Ventura ◽  
Tiziana Apuzzo ◽  
Mariaelena Capone ◽  
...  
Keyword(s):  
Natural Killer Cells ◽  
Natural Killer ◽  
Killer Cells ◽  
Metastatic Pathway

scholarly journals Molecular Alterations in Metastatic Ovarian Cancer From Gastrointestinal Cancer

2020 ◽  
Vol 10 ◽  
Author(s):  
Chao Chen ◽  
Xiaoxu Ge ◽  
Yamei Zhao ◽  
Da Wang ◽  
Limian Ling ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Gastrointestinal Cancer ◽  
Abdominal Cavity ◽  
Circulatory System ◽  
Hematogenous Spread ◽  
Molecular Alteration ◽  
Molecular Alterations ◽  
Metastatic Pathway ◽  
Metastatic Process ◽  
Distant Metastatic Site

Reports indicate that most metastatic ovarian cancer (MOC) originates from gastrointestinal cancer (GIC). Notably, GICs metastasize to the ovary frequently via 3 main routes including hematogenous spread, lymphogenous spread, and transcoelomic spread. Nonetheless, the mechanism of the progression remains unknown, and only a handful of literature exists on the molecular alteration implicated in MOC from GIC. This work collected existing evidence and literature on the vital molecules of the metastatic pathway and systematically analyzed them geared toward exploring the mechanism of the metastatic pathway of MOC. Further, this review described dominating molecular alteration in the metastatic process from cancer cells detaching away from lesions to arrive at the ovary, including factors for regulating signaling pathways in epithelial-interstitial transformation, invading, and surviving in the circulatory system or abdominal cavity. We interrogated the basis of the ovary as a distant metastatic site. This article provides new insights into the metastatic pathway and generates novel therapeutic targets for effective treatment and satisfactory outcomes in GIC patients.

scholarly journals A Case Report of Endobronchial Metastasis of Renal Cell Carcinoma with Reference to its Metastatic Pathway and Endobronchial Growth.

Haigan ◽  
1994 ◽  
Vol 34 (1) ◽  
pp. 103-108
Author(s):  
Yukitoshi Satoh ◽  
Shigehiro Tsuchiya ◽  
Sakae Okumura ◽  
Ken Nakagawa ◽  
Beniyo Kawabuchi ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Case Report ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Endobronchial Metastasis ◽  
Metastatic Pathway ◽  
Endobronchial Growth

Discovery of a metastatic pathway: implications for future cancer treatment

2011 ◽  
Vol 7 (6) ◽  
pp. 703-705
Author(s):  
George Hussey ◽  
Arindam Chaudhury ◽  
Philip H Howe
Keyword(s):  
Cancer Treatment ◽  
Metastatic Pathway

scholarly journals The natural adaptive evolution of cancer: The metastatic ability of cancer cells

2020 ◽  
Author(s):  
Gheorghe-Emilian Olteanu ◽  
Ioana-Maria Mihai ◽  
Florina Bojin ◽  
Oana Gavriliuc ◽  
Virgil Paunescu
Keyword(s):  
Stem Cell ◽  
Cancer Stem Cell ◽  
Cancer Cells ◽  
Epithelial Mesenchymal Transition ◽  
The Body ◽  
Mesenchymal Transition ◽  
Metastatic Pathway ◽  
New Treatment ◽  
New Hypothesis ◽  
Mesenchymal Epithelial Transition

The ability of cancer to adapt renders it one of the most challenging pathologies of all time. It is the most dreaded pathological entity because of its capacity to metastasize to distant sites in the body, and 90% of all cancer-related deaths recorded to date are attributed to metastasis. Currently, three main theories have been proposed to explain the metastatic pathway of cancer: the epithelial–mesenchymal transition (EMT) and mesenchymal–epithelial transition (MET) hypothesis (1), the cancer stem cell hypothesis (2), and the macrophage–cancer cell fusion hybrid hypothesis (3). We propose a new hypothesis, i.e., under the effect of particular biochemical and/or physical stressors, cancer cells can undergo nuclear expulsion with subsequent macrophage engulfment and fusion, with the formation of cancer fusion cells (CFCs). The existence of CFCs, if confirmed, would represent a novel metastatic pathway and a shift in the extant dogma of cancer; consequently, new treatment targets would be available for this adaptive pathology.

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