Malignant atrophic papulosis (Degos disease)

2021 ◽  
Author(s):  
Qiuyun Xu ◽  
Mengting Lin ◽  
Liangliang Zhang ◽  
Suni Chen ◽  
Ting Gong ◽  
...  
Keyword(s):  
Malignant Atrophic Papulosis ◽  
Degos Disease

scholarly journals Degos disease – malignant atrophic papulosis or cutaneointestinal lethal syndrome: rarity of the disease

2015 ◽  
pp. 141 ◽  
Author(s):  
Eduardo Pirolla ◽  
Felipe Fregni ◽  
Irene Miura ◽  
Antonio Misiara ◽  
Fernando Almeida ◽  
...  
Keyword(s):  
Malignant Atrophic Papulosis ◽  
Degos Disease

scholarly journals Clinical and Laboratory Prognosticators of Atrophic Papulosis (Degos Disease): A Systematic Review

2021 ◽  
Author(s):  
Justin D. Lu ◽  
Muskaan Sachdeva ◽  
Orli M. Silverberg ◽  
Lee Shapiro ◽  
David Croitoru ◽  
...  
Keyword(s):  
Systematic Review ◽  
Clinical Features ◽  
Systemic Disease ◽  
Central Nervous System Involvement ◽  
Vascular Disorder ◽  
Disease Evolution ◽  
Systemic Involvement ◽  
Reactive Protein ◽  
Malignant Atrophic Papulosis ◽  
Degos Disease

Abstract Background: Degos disease is a rare vascular disorder with a cutaneous-limited form, benign atrophic papulosis (BAP), and a systemic variant, malignant atrophic papulosis (MAP). Despite the poor prognosis of MAP, no study has established features associated with systemic disease.Objectives: The aims of this systematic review were to: (1) summarize clinical features and treatments implemented for patients with MAP and BAP (2) identify clinical and laboratory factors associated with the development of MAP, compared to BAP.Methods: We systematically searched MEDLINE and Embase from inception to April 2020. Demographic and clinical features of Degos patients were presented descriptively; multivariable logistic regression was performed to identify associations with MAP.Results: We identified 99 case studies, comprising 105 patients. MAP (64%) had a 2.15 year median survival time from cutaneous onset, most often with gastrointestinal or central nervous system involvement. We found that elevations in either of erythrocyte sedimentation rate (ESR) or C-reactive protein (CRP) were associated with systemic involvement (OR 2.27, p=0.023). Degos secondary to an autoimmune connective tissue disease was found to be inversely associated with MAP (OR 0.08, p=0.048).Conclusions: Elevated ESR or CRP is associated with MAP and may be a predictor of systemic involvement for patients with Degos disease. In addition, secondary Degos disease is associated with a favourable prognosis. Clinicians should be aware of the differences between primary and secondary Degos and the utility of ESR or CRP in identifying disease evolution to systemic involvement. The utility of ESR and CRP to identify systemic involvement should be further explored.

scholarly journals Malignant atrophic papulosis (Köhlmeier-Degos disease) - A review

2013 ◽  
Vol 8 (1) ◽  
pp. 10 ◽  
Author(s):  
Athanasios Theodoridis ◽  
Evgenia Makrantonaki ◽  
Christos C Zouboulis
Keyword(s):  
Malignant Atrophic Papulosis ◽  
Degos Disease

Ophthalmic Changes of Degos' Disease (Malignant Atrophic Papulosis)

Ophthalmology ◽  
1984 ◽  
Vol 91 (3) ◽  
pp. 295-299 ◽  
Author(s):  
David A. Lee ◽  
W.P. Daniel Su ◽  
Thomas J. Liesegang
Keyword(s):  
Malignant Atrophic Papulosis ◽  
Degos Disease ◽  
Ophthalmic Changes
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