scholarly journals A review of actinic keratosis, skin field cancerisation and the efficacy of topical therapies

2020 ◽  
Author(s):  
Robert Sinclair ◽  
Christopher Baker ◽  
Lynda Spelman ◽  
Madeleine Supranowicz ◽  
Beth MacMahon
Keyword(s):  
Actinic Keratosis ◽  
Field Cancerisation

Prevalence of solar damage and actinic keratosis in a Merseyside population: reply from authors

2001 ◽  
Vol 144 (2) ◽  
pp. 437-438
Author(s):  
A.A. Memon ◽  
J.A. Tomenson ◽  
J. Bothwell ◽  
P.S. Friedmann
Keyword(s):  
Actinic Keratosis

Long-term efficacy of a new medical device containing Fernblock® and DNA repair enzyme complex in the treatment and prevention of cancerization field in patients with actinic keratosis.

2019 ◽  
Vol 2 (02) ◽  
pp. 80-89
Author(s):  
Blanca De Unamuno Bustos ◽  
Natalia Chaparr´´o Aguilera ◽  
Inmaculada Azorín García ◽  
Anaid Calle Andrino ◽  
Margarita Llavador Ros ◽  
...  
Keyword(s):  
Dna Damage ◽  
Dna Repair ◽  
Medical Device ◽  
Actinic Keratosis ◽  
Statistical Significance ◽  
Dna Lesions ◽  
Enzyme Complex ◽  
Repair Enzyme ◽  
P53 Expression ◽  
Cancerization Field

Actinic keratosis (AKs) are part of the cancerization field, a region adjacent to AKs containing subclinical and histologically abnormal epidermal tissue due to Ultraviolet (UV)-induced DNA damage. The photoproducts as consequence of DNA damage induced by UV are mainly cyclobutane pyrimidine dimers (CPDs). Fernblock® demonstrated in previous studies significant reduction of the number of CPDs induced by UV radiation. Photolyases are a specific group of enzymes that remove the major UV-induced DNA lesions by a mechanism called photo-reactivation. A monocentric, prospective, controlled, and double blind interventional study was performed to evaluate the effect of a new medical device (NMD) containing a DNA-repair enzyme complex (photolyases, endonucleases and glycosilases), a combination of UV-filters, and Fernblock® in the treatment of the cancerization field in 30 AK patients after photodynamic therapy. Patients were randomized into two groups: patients receiving a standard sunscreen (SS) andpatients receiving the NMD. Clinical, dermoscopic, reflectance confocal microscopy (RCM) and histological evaluations were performed. An increase of AKs was noted in all groups after three months of PDT without significant differences between them (p=0.476). A significant increase in the number of AKs was observed in SS group after six (p=0.026) and twelve months of PDT (p=0.038); however, this increase did not reach statistical significance in the NMD group. Regarding RCM evaluation, honeycomb pattern assessment after twelve months of PDT showed significant differences in the extension and grade of the atypia in the NMD group compared to SS group (p=0.030 and p=0.026, respectively). Concerning histopathological evaluation, keratinocyte atypia grade improved from baseline to six months after PDT in all the groups, with no statistically significant differences between the groups. Twelve months after PDT, p53 expression was significantly lower in the NMD group compared to SS group (p=0.028). The product was well-tolerated, with no serious adverse events reported. Our results provide evidence of the utility of this NMD in the improvement of the cancerization field and in the prevention of the development of new AKs.  

Making proper judgement when choosing a treatment for actinic keratosis

2013 ◽  
pp. 1-9 ◽  
Author(s):  
Jan-Christoph Simon ◽  
Bruce Thiers ◽  
Matthias Augustin
Keyword(s):  
Actinic Keratosis

Actinic keratosis and dermal elastotic degeneration.

1990 ◽  
Vol 52 (2) ◽  
pp. 306-309
Author(s):  
Jun YAMAGUCHI ◽  
Seiji KONDO ◽  
Akira KAWADA ◽  
Yoshiaki SATOH
Keyword(s):  
Actinic Keratosis

Safety and Efficacy of Topical Use of Imiquimod (Beselna Cream 5％) for the Treatment of Actinic Keratosis : A Retrospective Multicenter Collaborative Clinical Study

2016 ◽  
Vol 78 (4) ◽  
pp. 408-413 ◽  
Author(s):  
Masahito YASUDA ◽  
Etsuko OKADA ◽  
Michiko HASEGAWA, ◽  
Yukie ENDO ◽  
Keiichiro RYUZAKI ◽  
...  
Keyword(s):  
Clinical Study ◽  
Actinic Keratosis ◽  
Safety And Efficacy

Evaluation of Therapeutic Effectiveness of Photodynamic Therapy (PDT) Using Metal Halide Lamp for Actinic Keratosis and Bowen's Disease

2011 ◽  
Vol 73 (3) ◽  
pp. 260-265
Author(s):  
Toshinori BITO ◽  
Shun OHMORI ◽  
Mayuko YOSHIZAWA ◽  
Sanehito HARUYAMA ◽  
Yu SAWADA ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Actinic Keratosis ◽  
Metal Halide ◽  
Therapeutic Effectiveness ◽  
Bowen’S Disease ◽  
Bowen's Disease ◽  
Metal Halide Lamp
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