Simultaneous presentation of Lupus Erythematosus in a mother and a sibling pair

2020 ◽  
Vol 61 (4) ◽  
Author(s):  
Dimitra Koumaki ◽  
George Bertsias ◽  
Antonios Rogdakis ◽  
Vrettos HaniotIs ◽  
George Evangelou ◽  
...  
Keyword(s):  
Lupus Erythematosus ◽  
Simultaneous Presentation ◽  
Sibling Pair

Simultaneous Presentation of Rheumatoid Arthritis in a Sibling Pair

Rheumatology ◽  
1994 ◽  
Vol 33 (9) ◽  
pp. 889-890 ◽  
Author(s):  
C. J. McCARTHY ◽  
S. EUSTACE ◽  
R. J. COUGHLAN
Keyword(s):  
Rheumatoid Arthritis ◽  
Simultaneous Presentation ◽  
Sibling Pair

Simultaneous presentation of systemic lupus erythematosus and lupus nephritis in mother and son

Lupus ◽  
2011 ◽  
Vol 20 (14) ◽  
pp. 1541-1546 ◽  
Author(s):  
F Lin ◽  
C Zhang ◽  
D Zhang ◽  
X Wu ◽  
C Zhu ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Nephritis ◽  
Lupus Erythematosus ◽  
Renal Involvement ◽  
Monozygotic Twins ◽  
Simultaneous Presentation ◽  
Class Iii ◽  
Systemic Lupus ◽  
Cutaneous Lesions ◽  
Complex Interactions

The pathogenesis of systemic lupus erythematosus (SLE) has been attributed to complex interactions between genetic, hormonal and environmental factors. The influence of a genetic predisposition to SLE is supported by family aggregation and a high concordance rate in monozygotic twins. Here we present a rare case of simultaneous presentation of SLE and lupus nephritis in a mother and son. Both patients had nephrotic-range proteinuria, and the renal pathological classifications of the son and his mother were Class IV-G (A) and Class III (A/C), respectively, according to the International Society of Nephrology/Renal Pathology Society (ISN/RPS) 2003 classification of lupus nephritis. Apart from the renal involvement, both patients had leucopenia and anemia, and the mother also had typical cutaneous lesions and secondary Sjögren’s syndrome. This case supports the genetic role in the etiology of SLE, and displayed different clinical presentations and disease severity in familial SLE patients of different gender and age.

scholarly journals Simultaneous Presentation of Parvovirus B19 Infection and Systemic Lupus Erythematosus in a Patient: Description and Review of the Literature

2020 ◽  
Author(s):  
Paul Chabert ◽  
Hatem Kallel
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Primary Infection ◽  
Parvovirus B19 ◽  
Immunosuppressive Agents ◽  
Delayed Diagnosis ◽  
Simultaneous Presentation ◽  
Review Of The Literature ◽  
Systemic Lupus ◽  
Parvovirus B19 Infection

We present the case of a 25-year-old woman without medical history, presenting with acute respiratory failure needing mechanical ventilation. Aetiologic screening showed PVB19 primary infection and concomitant SLE flare-up. We discuss the causative interactions between PVB19 and SLE in the pathogenesis of the disease. Difficulty diagnosing inaugural SLE flare-up concomitant with PVB19 infection can lead to delayed diagnosis and treatment. Inversely, overtreating a SLE-mimicking PVB19 infection with immunosuppressive agents can be highly detrimental.

Organized Intraglomerular Deposits in NZB Mouse Disease

1971 ◽  
Vol 29 ◽  
pp. 544-545
Author(s):  
Francis R. Comerford ◽  
Alan S. Cohen
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Antinuclear Antibodies ◽  
Human Systemic Lupus Erythematosus ◽  
Systemic Lupus ◽  
Glomerular Lesion ◽  
Ultrastructural Studies ◽  
Dense Deposits ◽  
Experimental Nephritis ◽  
Glomerular Lesions

Mice of the inbred NZB strain develop a spontaneous disease characterized by autoimmune hemolytic anemia, positive lupus erythematosus cell tests and antinuclear antibodies and nephritis. This disease is analogous to human systemic lupus erythematosus. In ultrastructural studies of the glomerular lesion in NZB mice, intraglomerular dense deposits in mesangial, subepithelial and subendothelial locations were described. In common with the findings in many examples of human and experimental nephritis, including many cases of human lupus nephritis, these deposits were amorphous or slightly granular in appearance with no definable substructure.We have recently observed structured deposits in the glomeruli of NZB mice. They were uncommon and were found in older animals with severe glomerular lesions by morphologic criteria. They were seen most commonly as extracellular elements in subendothelial and mesangial regions. The deposits ranged up to 3 microns in greatest dimension and were often adjacent to deposits of lipid-like round particles of 30 to 250 millimicrons in diameter and with amorphous dense deposits.

“Subcortical” cognitive impairment in patients with systemic lupus erythematosus

2000 ◽  
Vol 6 (7) ◽  
pp. 821-825 ◽  
Author(s):  
ELIZABETH LERITZ ◽  
JASON BRANDT ◽  
MELISSA MINOR ◽  
FRANCES REIS-JENSEN ◽  
MICHELLE PETRI
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Cognitive Impairment ◽  
Lupus Erythematosus ◽  
Systemic Lupus
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