Rosai–Dorfman disease masquerading as an isolated cutaneous nodule

2019 ◽  
Vol 60 (4) ◽  
pp. 326-327
Author(s):  
Adrian Jonathan Sykes ◽  
Duncan Lamont ◽  
Ben Tallon ◽  
Neil J Mortimer
Keyword(s):  
Rosai Dorfman Disease ◽  
Cutaneous Nodule

scholarly journals Rosai-Dorfman Disease with Massive Cutaneous Nodule on the Shoulder and Back

2015 ◽  
Vol 27 (1) ◽  
pp. 71 ◽  
Author(s):  
Han Ma ◽  
Yue Zheng ◽  
Guoxing Zhu ◽  
Jie Wu ◽  
Chun Lu ◽  
...  
Keyword(s):  
Rosai Dorfman Disease ◽  
Cutaneous Nodule

Rosai-Dorfman Disease Presenting as a Lateral Skull Base Tumor with Intracranial Spread: A Case Report

2019 ◽  
Author(s):  
Gauri Mankekar ◽  
George Jeha ◽  
Ma Arriaga ◽  
Kelly Scrantz ◽  
J. Olson
Keyword(s):  
Case Report ◽  
Skull Base ◽  
Skull Base Tumor ◽  
Lateral Skull Base ◽  
Rosai Dorfman Disease

Clinical Manifestations and Radiological Characteristics on Rosai-Dorfman Disease: A Retrospective Observational Study

2020 ◽  
Vol 5 (5) ◽  
Keyword(s):  
Blood Vessels ◽  
Abdominal Cavity ◽  
Clinical Manifestations ◽  
Ct Images ◽  
High Signal ◽  
Radiological Features ◽  
Imaging Characteristics ◽  
Rosai Dorfman Disease ◽  
Heterogeneous Enhancement ◽  
The Masses

Background and Objective: Rosai-Dorfman disease (RDD) are usually misdiagnosed because of rarity and nonspecific clinical and radiological features. The aim of our study is to explore the clinical and imaging characteristics of RDD to improve diagnostic accuracy. Methods: Clinical and imaging data in 10 patients with RDD were retrospectively analyzed. 7 patients were underwent CT scanning and 3 patients were underwent MR examination. Results: 8 (8/10) patients presented with painless enlarged lymph nodes (LNs) or mass. 3 cases were involved with LNs, 5 cases were involved with extra-nodal tissues, and the remaining 2 cases were involved with LNs and extra-nodal tissue simultaneously. In enhanced CT images, enlarged LNs displayed mild or moderate enhancement, and 2 cases showed heterogeneous ring-enhancement. MR features of 3 patients with extra-nodal RDD, 2 cases showed a mass located in the subcutaneous and anterior abdominal wall respectively, and 1 case showed an intracranial mass. Besides, all lesions showed high signal foci on DWI images, and were characterized by marked heterogeneous enhancement with blurred edge. The dural/fascia tail sign and dilated blood vessels could be seen around all the lesions on enhanced MRI. Radiological features of 2 cases with LN and extranodal tissue involved, one case presented with the swelling and thickening of pharyngeal lymphoid ring and nasopharynx, meanwhile with enlarged LNs in bilateral submandibular area, neck and abdominal cavity, and also companied with osteolytic lesion in right proximal humerus. All these LNs displayed mild and moderate enhancement on CT images. Another case showed enlarged LNs in bilateral neck accompanied with soft tissue mass in the sinuses. Conclusions: RDD occurred commonly in young and middle-aged men and presented with painless enlarged LNs or mass.RDD had a huge diversity of imaging findings, which varied with different location. The radiological features, such as small patches of high signal foci in the masses on DWI images, heterogeneous enhancement and blood vessels around the masses, are helpful in diagnosis of extranodal RDD.

Skin limited Rosai-Dorfman disease with elevated IgG4 positive plasma cells

2018 ◽  
Author(s):  
Iñigo Gorostiaga ◽  
ÁLVARO PÉREZ RODRÍGUEZ ◽  
ÁLVARO ['Noelia'] ◽  
jose javier aguirre
Keyword(s):  
Plasma Cells ◽  
Rosai Dorfman Disease

scholarly journals Isolated cerebral Rosai–Dorfman disease presenting as a sole mass protruding into the fourth ventricle: A case report

2021 ◽  
Vol 16 (7) ◽  
pp. 1613-1617
Author(s):  
Guillaume Friconnet ◽  
Mathilde Duchesne ◽  
Marcel Gueye ◽  
François Caire ◽  
Charbel Mounayer ◽  
...  
Keyword(s):  
Case Report ◽  
Fourth Ventricle ◽  
Rosai Dorfman Disease

scholarly journals Primary Rosai-Dorfman disease of tibia: A case report

2021 ◽  
Author(s):  
Lu Yu ◽  
Zhouming Deng ◽  
Lin Cai ◽  
Qiongrong Chen
Keyword(s):  
Case Report ◽  
Rosai Dorfman Disease

Extra-nodal Rosai-Dorfman Disease Confined to Breast

2020 ◽  
Vol 154 (Supplement_1) ◽  
pp. S41-S42
Author(s):  
E Ozluk ◽  
R Shackelford
Keyword(s):  
Plasma Cells ◽  
African American Woman ◽  
American Woman ◽  
Lymphocytic Infiltration ◽  
Needle Aspiration ◽  
Left Breast ◽  
Unknown Etiology ◽  
Diagnostic Challenge ◽  
Ductal Cells ◽  
Rosai Dorfman Disease

Abstract Introduction/Objective First described by Rosai and Dorfman in 1969, Rosai-Dorfman Disease (RDD) is an uncommon, idiopathic, reactive lymph node process with an unknown etiology. It may involve extra-nodal organs including the skin, bone, soft tissue, and eyes. However, breast involvement is rare and RDD confined to breast without nodal involvement is extremely uncommon. Methods Here we present a case of RDD confined to breast. The patient was a 51-year-old African American woman who was found to have an irregular, solid left breast mass on routine mammogram, which had speculated irregular margins and measured of 37.0 x 32.0 x 32.0 mm. She did not have any symptoms, nor any palpable lymph nodes. The clinician stated that the lesion was highly suspicious for a breast malignancy and requested a fine needle aspiration (FNA) of the mass, followed by total excision. Results An FNA was interpreted as atypical histiocytic cells in a mixed lymphoid background. Histopathologic examination revealed an ill-defined mass with sheets of histiocytes, plasma cells, and a mixed lymphocytic population, with occasional germinal centers. Some of the histiocytes were spindle shaped and associated with storiform collagen deposition. The histiocytes had single and multiple nuclei and exhibited occasional emperipolesis. Immunohistochemical staining with S100 diffusely highlighted the histiocytes, whereas CD1a was negative. CD3 and CD20 immunostains were positive for mixed-type lymphocytic infiltration. Cytokeratin staining was performed and reassuringly stained only the benign ductal cells. A diagnosis of RDD of the breast was made, based on these histopathologic findings. Conclusion We report an example of an extra-nodal RDD involving the mammary gland that was initially suspected to be breast carcinoma. RDD may still be a diagnostic challenge, especially in a patient with suspected carcinoma. It is the pathologist’s role to lead the clinician to the proper diagnosis and render a correct histopathologic diagnosis.

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