Lepromatous leprosy with Lucio's phenomenon

2017 ◽  
Vol 59 (1) ◽  
pp. 62-63
Author(s):  
Yan-Fei Wang ◽  
Ping Wang ◽  
Hui Huang
Keyword(s):  
Lepromatous Leprosy ◽  
Lucio’S Phenomenon

scholarly journals Lucio Phenomenon mimicking with Vasculo necrotic Erithema Nodosum Leprosum: A Case Report

2020 ◽  
Vol 13 (3) ◽  
pp. 288-294
Author(s):  
Dwi Sepfourteen ◽  
Tutty Ariani
Keyword(s):  
Endothelial Cell ◽  
Erythema Nodosum ◽  
Lepromatous Leprosy ◽  
Lower Limbs ◽  
Acid Fast Bacilli ◽  
Erythema Nodosum Leprosum ◽  
Endothelial Proliferation ◽  
Hands And Feet ◽  
Epidermal Necrosis ◽  
Lucio’S Phenomenon

Clinical features of Lucio’s phenomenon (LP), shows a nectorizing erythema, may mimicking Erythema Nodosum leprosum with vasculonecrotic. A 46 years old man presented with diagnosis lepromatous leprosy with Lucio’s phenomenon and diferential diagnosis borderline lepromatous (BL) with vasculonecrotic erithema nodosum leprosum. The patients complained there were painless ulcers on his lower limbs and scrotum, with surrounded by purpuric patches which subsequently became gangrenes and ulcerated for 3 weeks. There was numbness of both hands and feet, the eyelashes, eyebrows baldness since 5 years ago. Patient never got the treatment before. Bacteriological examination showed bacterial index 6+ Histopathology: there were Flattened epidermis by narrow grenz zone, and lymphocyte in perivascular with macrophage. There was endothelial proliferation of capiller. Fite faraco stain showed macrophage infiltration around the perivasculer, with colonization of the endothelial cell by acid fast bacilli and epidermal necrosis and diagnosis as Lepromatous leprosy with Lucio phenomenon. This patient is given adult multiple drug therapy (MDT) therapy, methylprednisolone, neurotrophic vitamins. Lucio’s phenomenon most commonly affects patients with untreated leprosy. Clinically, it may be difficult to differentiate Lucio phenomenon from Erythema nodosum leprosum with vasculonecrotic. In this case, the histopathological examination were colonization of endothelial cell by acid fast bacilli, epidermal necrosis and endothelial proliferation of the vessel.

scholarly journals Lucio's phenomenon: another case reported in Brazil

2012 ◽  
Vol 87 (2) ◽  
pp. 296-300 ◽  
Author(s):  
Rodrigo Monteiro ◽  
Marcelo Guimarães Tiezzi ◽  
Marilda Aparecida Milanez Morgado de Abreu ◽  
Claudia Cardoso Macedo de Oliveira ◽  
Eduardo Vinícios Mendes Roncada ◽  
...  
Keyword(s):  
Rare Event ◽  
Lepromatous Leprosy ◽  
Coagulation System ◽  
Multidrug Therapy ◽  
Tissue Necrosis ◽  
Inflammatory Reactions ◽  
Vascular Lumen ◽  
Endothelial Proliferation ◽  
Lucio’S Phenomenon

Lucio's phenomenon is defined as a variant of type 2 leprosy reaction. It is a rare event, occurring in the evolution of leprosy of Lucio and other forms of lepromatous leprosy. It has an exacerbated proliferation of Hansen bacilli in its pathophysiology, which invade blood vessel walls and injure endothelial cells, causing endothelial proliferation and decreasing the vascular lumen. This fact, associated with inflammatory reactions and changes in the coagulation system causes vascular thrombosis, ischemia, infarction and tissue necrosis, leading to the histopathological characteristic of the phenomenon. We report a case of lepromatous leprosy with irregular treatment that developed Lucio's phenomenon. Treatment with multidrug therapy, antibiotics, steroids and thalidomide achieved a favorable outcome.

scholarly journals Diffuse Necrotic Ulcerations Revealing Lepromatous Leprosy with Lucio's Phenomenon

2017 ◽  
Vol 02 (02) ◽  
Author(s):  
Ousmane Faye ◽  
Adama Dicko ◽  
Bekaye Traore ◽  
Siritio Berthe ◽  
Karim Coulibaly ◽  
...  
Keyword(s):  
Lepromatous Leprosy ◽  
Lucio’S Phenomenon

ORAL LESIONS IN PATIENT WITH LEPROMATOUS LEPROSY AND LUCIO'S PHENOMENON

2017 ◽  
Vol 124 (2) ◽  
pp. e51
Author(s):  
GIOVANI ANTONIO RODRIGUES ◽  
NAIARA PRISCILA QUALIO ◽  
FERNANDA ANDRÉ MARTINS CRUZ PERECIN ◽  
JOÃO CARLOS LOPES SIMÃO ◽  
LARA MARIA ALENCAR RAMOS INNOCENTINI ◽  
...  
Keyword(s):  
Lepromatous Leprosy ◽  
Oral Lesions ◽  
Lucio’S Phenomenon

scholarly journals Lucio's Phenomenon. Case study of an exceptional response to treatment exclusively with multibacillary multidrug therapy

2013 ◽  
Vol 88 (6 suppl 1) ◽  
pp. 93-96 ◽  
Author(s):  
Amanda Braga Peixoto ◽  
Poliana Santin Portela ◽  
Fabiano Roberto Pereira de Carvalho Leal ◽  
Arles Martins Brotas ◽  
Nilton Carlos dos Santos Rodrigues
Keyword(s):  
Weight Loss ◽  
Male Patient ◽  
Lepromatous Leprosy ◽  
Response To Treatment ◽  
Multidrug Therapy ◽  
Cutaneous Lesions ◽  
Histopathological Findings ◽  
Lucio’S Phenomenon

Lucio's phenomenon represents a serious cutaneous necrotizing reaction, which can occur with Lucio's leprosy and also in other forms of lepromatous leprosy. The authors discuss the case of a 63-year-old male patient presenting with ulcers and necrotic cutaneous lesions on the limbs, torso and face, associated with recurring sinusitis, hoarseness and a weight loss of 25 kilos over the last year. Bacilloscopy of intradermal scrapings showed a bacilloscopic index of 5 and the histopathological findings were compatible with the diagnosis of Lucio's phenomenon. The chosen treatment was exclusively multibacillary multidrug therapy, resulting in important dermatological improvement after one month of therapy. The authors present an impressive case of Lucio's phenomenon with an exceptional response to treatment exclusively with multibacillary multidrug therapy.

Lucio's phenomenon: An immune complex deposition syndrome in lepromatous leprosy

1978 ◽  
Vol 9 (2) ◽  
pp. 184-193 ◽  
Author(s):  
Francisco P. Quismorio ◽  
Thomas Rea ◽  
Stebbins Chandor ◽  
Norman Levan ◽  
George J. Friou
Keyword(s):  
Immune Complex ◽  
Lepromatous Leprosy ◽  
Immune Complex Deposition ◽  
Complex Deposition ◽  
Lucio’S Phenomenon
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