Lower limb linear morphoea in a pregnant woman with known Graves' disease and cytomegalovirus immunoglobulin M positivity

2014 ◽  
Vol 56 (4) ◽  
pp. e96-e98 ◽  
Author(s):  
Brittany Wong ◽  
Peter Piliouras ◽  
Rohan Mortimore ◽  
Mark Zonta ◽  
Simon Tucker
Keyword(s):  
Pregnant Woman ◽  
Lower Limb ◽  
Immunoglobulin M ◽  
Graves Disease

scholarly journals Antiphospholipid Antibody Syndrome Associated with Graves' Disease Presenting as Inferior Vena Cava Thrombosis with Bilateral Lower Limb DVT

2014 ◽  
Vol 7 ◽  
pp. CCRep.S15302 ◽  
Author(s):  
Ankur Jain
Keyword(s):  
Inferior Vena Cava ◽  
Lower Limb ◽  
Inferior Vena ◽  
Case Reports ◽  
Vena Cava ◽  
Antithyroid Drugs ◽  
Graves Disease ◽  
Antiphospholipid Antibody ◽  
Antiphospholipid Antibody Syndrome ◽  
Bilateral Lower Limb

We report a case of a 60-year-old lady who presented with bilateral lower limb swelling and a thyroid swelling with clinical features consistent with thyrotoxicosis. Investigations revealed the presence of a thrombus in bilateral external, internal iliac veins, and inferior vena cava extending up to its infrahepatic part. Hormone profile and radioiodine uptake scan confirmed the diagnosis of Graves' disease. Further workup revealed the presence of antiphospholipid antibodies (confirmed after a repeat test at 12 weeks). The patient was treated with antithyroid drugs and anticoagulants. The patient improved with normalization of thyroid function and partial recanalization of the infrahepatic part of inferior vena cava. Hyperthyroidism has been implicated as a potential hypercoagulable state; however, the association of Graves' disease with antiphospholipid antibody syndrome is limited to isolated case reports. This case highlights a new mechanism underlying hypercoagulability associated with Graves' disease.

scholarly journals Fetal goiter identified in a pregnant woman with triiodothyronine-predominant graves’ disease: a case report

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Akiko Fujishima ◽  
Akira Sato ◽  
Hiroshi Miura ◽  
Yuki Shimoda ◽  
Saeko Kameyama ◽  
...  
Keyword(s):  
Case Report ◽  
Pregnant Woman ◽  
Graves Disease ◽  
Fetal Goiter

scholarly journals Development of Immunoglobulin M Nephropathy in a Pregnant Woman

Cureus ◽  
2021 ◽  
Author(s):  
Koray Uludag ◽  
Yesim Celik ◽  
Nuray Yildirimer ◽  
Fatos Tekelioglu ◽  
Ali Ihsan Gunal
Keyword(s):  
Pregnant Woman ◽  
Immunoglobulin M

scholarly journals Deep Vein Thrombosis Secondary To Graves' Disease-A Case Report

2016 ◽  
Vol 5 (1) ◽  
pp. 33-41
Author(s):  
Md Aminul Islam ◽  
Ayesha Beg ◽  
Md Sultan Ahmed ◽  
Sayed Chowdhury ◽  
Mirza Manjurul Haque
Keyword(s):  
Deep Vein Thrombosis ◽  
Case Report ◽  
Thyroid Hormone ◽  
Thyroid Gland ◽  
Lower Limb ◽  
Graves Disease ◽  
Pathophysiological Mechanism ◽  
Vein Thrombosis ◽  
Deep Vein ◽  
Overt Hyperthyroidism

Deep Vein thrombosis (DVT) is the formation of a blood clot within a deep vein, most commonly the legs. The incidence of a first venous thrombosis is 1-3 per 1000 persons per year, around two-thirds manifest as DVT of the leg, and one-third as pulmonary embolism (PE). Graves' disease, also known as toxic diffuse goiter, is an autoimmune disease that affects the thyroid which frequently results in and is the most common cause of hyperthyroidism, often results in an enlarged thyroid. The disorder results from an antibody, called thyroid stimulating immunoglobulin (TSI), that has a similar effect to thyroid stimulating hormone (TSH) which cause the thyroid gland to produce excess thyroid hormone. Graves' disease will develop in about 0.5% of males and 3% of females, approximately 7.5 times more often in women than men. Various changes in the coagulation- fibrinolytic system have been described in patients with an excess thyroid hormones particularly procoagulant and antifibrinolytic effects. Review analysis confirmed that clinically overt hyperthyroidism modify the coagulation-fibrinolytic balance, indicating that thyroid hormone excess is the probable main pathophysiological mechanism. Patients with overt hyperthyroidism appear to have an increased risk of thrombosis. Here we present a case of right sided leg swelling due to deep vein thrombosis with Grave's disease A 30 year old lady admitted in tertiary care hospital with right sided leg swelling for 25 days and protrusion of both eyes for 3 months. Swelling was sudden in onset, painful, red in colour, which involved almost whole right lower limb and it was associated with venous engorgement. Physical examination revealed patient was ill looking, mildly anaemic, tachycardic, normotensive, severe pitting edema on right leg but left was normal. Thyroid gland was diffusely enlarged. She had bilateral exopthalmos with presence of lid retraction and lid lag. Examination of Lower limbs revealed swollen whole right lower limb with engorged veins in the upper part of thigh with raised local temperature, calf muscle tenderness and positive Homan's sign on right side. The purpose of this case report is to establish that Graves' disease is the cause of DVT in this patient. CBMJ 2016 January: Vol. 05 No. 01 P: 33-41

Electron Microscopic identification of Pre-B Lymphocytes in the Bone Marrow of a Patient with Chronic Myelocytic Leukemic in Blast Crisis

1982 ◽  
Vol 40 ◽  
pp. 346-347
Author(s):  
T. Mullin ◽  
G. Yee ◽  
M. Aheam ◽  
J. Trujillo
Keyword(s):  
Blast Crisis ◽  
Immunoglobulin M ◽  
Terminal Deoxynucleotidyl Transferase ◽  
Transformation Theory ◽  
Electron Microscopic ◽  
Chemotherapeutic Sensitivity ◽  
Microscopic Studies ◽  
Hematopoietic Precursor ◽  
Lymphoblastic Transformation ◽  
B Lineage

There have been numerous reports in the current literature suggesting that hematopoietic precursor cells in some human chronic myelocytic leukemias (CML) undergo lymphoblastic transformation at the time of the acute blast crisis (BC) stage. The primary evidence offered in support of this transformation theory--lymphoblastic appearing morphology, increased terminal deoxynucleotidyl transferase (TdT) activity, and chemotherapeutic sensitivity to vincristine and prednisone--has been indirect, however, since these features may occur in nonlymphoid cells. More direct support for the Pre-B lineage of these cells has recently been provided by immunofluorescent light microscopic studies demonstrating the presence of intracytoplasmic immunoglobulin M (IgM) in these CML-BC cells.

High-resolution scanning electron microscopy in biology

1990 ◽  
Vol 48 (3) ◽  
pp. 14-15
Author(s):  
Keiichi Tanaka
Keyword(s):  
High Resolution ◽  
Immunoglobulin M ◽  
Metal Coating ◽  
Biological Macromolecules ◽  
Ultrahigh Resolution ◽  
Preparation Methods ◽  
Low Contrast ◽  
Almost All ◽  
Charging Effect ◽  
Scanning Electron

With the development of scanning electron microscope (SEM) with ultrahigh resolution, SEM became to play an important role in not only cytology but also molecular biology. However, the preparation methods observing tiny specimens with such high resolution SEM are not yet established.Although SEM specimens are usually coated with metals for getting electrical conductivity, it is desirable to avoid the metal coating for high resolution SEM, because the coating seriously affects resolution at this level, unless special coating techniques are used. For avoiding charging effect without metal coating, we previously reported a method in which polished carbon plates were used as substrate. In the case almost all incident electrons penetrate through the specimens and do not accumulate in them, when the specimens are smaller than 10nm. By this technique some biological macromolecules including ribosomes, ferritin, immunoglobulin G were clearly observed.Unfortunately some other molecules such as apoferritin, thyroglobulin and immunoglobulin M were difficult to be observed only by the method, because they had very low contrast and were easily damaged by electron beam.

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