Risk factors for locoregional relapse after radical nephrectomy

2017 ◽  
Vol 14 (3) ◽  
pp. 192-197
Author(s):  
Sameer Jhavar ◽  
Gregory Swanson ◽  
Jessica Pruszynski
Keyword(s):  
Risk Factors ◽  
Radical Nephrectomy ◽  
Locoregional Relapse

Identifying patients with CKD risk at the time of nephrectomy: When to initiate nephrology consult

2021 ◽  
pp. 239936932110319
Author(s):  
Yihe Yang ◽  
Zachary Kozel ◽  
Purva Sharma ◽  
Oksana Yaskiv ◽  
Jose Torres ◽  
...  
Keyword(s):  
Risk Factors ◽  
Multivariate Analysis ◽  
Radical Nephrectomy ◽  
Mixed Model ◽  
Linear Mixed Model ◽  
Interstitial Fibrosis ◽  
Kidney Neoplasm ◽  
Tubular Atrophy ◽  
Independent Risk Factors

Introduction: The prevalence of chronic kidney disease (CKD) is high among kidney neoplasm patients because of the overlapping risk factors. Our purpose is to identify kidney cancer survivors with higher CKD risk. Methods: We studied a retrospective cohort of 361 kidney tumor patients with partial or radical nephrectomy. Linear mixed model was performed. Results: Of patients with follow-up >3 months, 84% were identified retrospectively to fulfill criteria for CKD diagnosis, although CKD was documented in only 15%. Urinalysis was performed in 205 (57%) patients at the time of nephrectomy. Multivariate analysis showed interstitial fibrosis and tubular atrophy (IFTA) >25% ( p = 0.005), severe arteriolar sclerosis ( p = 0.013), female gender ( p = 0.024), older age ( p = 0.012), BMI ⩾ 25 kg/m2 ( p < 0.001), documented CKD ( p < 0.001), baseline eGFR ⩽ 60 ml/min/1.73 m2 ( p < 0.001), and radical nephrectomy ( p < 0.001) were independent risk factors of lower eGFR at baseline and during follow-up. Average eGFR decreased within 3 months post nephrectomy. However, patients with different risk levels showed different eGFR time trend pattern at longer follow-ups. Multivariate analysis of time × risk factor interaction showed BMI, radical nephrectomy and baseline eGFR had time-dependent impact. BMI ⩾ 25 kg/m2 and radical nephrectomy were associated with steeper eGFR decrease slope. In baseline eGFR > 90 ml/min/1.73 m2 group, eGFR rebounded to pre-nephrectomy levels during extended follow-up. In partial nephrectomy patients with baseline eGFR ⩾ 90 ml/min/1.73 m2 ( n = 61), proteinuria ( p < 0.001) and BMI ( p < 0.001) were independent risk factors of decreased eGFR during follow up. Conclusions: As have been suggested by others and confirmed by our study, proteinuria and CKD are greatly under-recognized. Although self-evident as a minimum workup for nephrectomy patients to include SCr, eGFR, urinalysis, and proteinuria, the need for uniform applications of this practice should be reinforced. Non-neoplastic histology evaluation is valuable and should include an estimate of global sclerosis% (GS) and IFTA%. Patients with any proteinuria and/or eGFR ⩽ 60 at the time of nephrectomy or in follow-up with urologists, and/or >25% GS or IFTA, should be referred for early nephrology consultation.

Chronic pulmonary diseases are independent risk factors for complications after radical nephrectomy

2011 ◽  
Vol 43 (4) ◽  
pp. 1025-1031 ◽  
Author(s):  
Hüsnü Tokgöz ◽  
Bülent Akduman ◽  
İlker Ünal ◽  
Bülent Erol ◽  
Ersöz Akyürek ◽  
...  
Keyword(s):  
Risk Factors ◽  
Radical Nephrectomy ◽  
Pulmonary Diseases ◽  
Chronic Pulmonary Diseases ◽  
Independent Risk Factors

Identifying Incidence and Risk Factors for Venous Thromboembolism among Partial and Radical Nephrectomy Patients for Kidney Cancer

2014 ◽  
Vol 219 (3) ◽  
pp. S150-S151
Author(s):  
Abram McBride ◽  
Maxim J. McKibben ◽  
Josip Vukina ◽  
Jonathan Matthews ◽  
Raj Pruthi ◽  
...  
Keyword(s):  
Risk Factors ◽  
Venous Thromboembolism ◽  
Kidney Cancer ◽  
Radical Nephrectomy

scholarly journals Comparison of Risk Factors for the Development of Proteinuria After Radical Nephrectomy for Renal Cell Carcinoma

2021 ◽  
Vol Volume 13 ◽  
pp. 407-414
Author(s):  
Chung Un Lee ◽  
Don Kyoung Choi ◽  
Jae Hoon Chung ◽  
Wan Song ◽  
Minyong Kang ◽  
...  
Keyword(s):  
Risk Factors ◽  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Radical Nephrectomy

scholarly journals Prognostic Outcomes and Risk Factors for Patients with Renal Cell Carcinoma and Venous Tumor Thrombus after Radical Nephrectomy and Thrombectomy: The Prognostic Significance of Venous Tumor Thrombus Level

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Qi Tang ◽  
Yi Song ◽  
Xuesong Li ◽  
Maxwell Meng ◽  
Qian Zhang ◽  
...  
Keyword(s):  
Risk Factors ◽  
Renal Cell Carcinoma ◽  
Survival Rate ◽  
Cell Carcinoma ◽  
Hepatic Vein ◽  
Renal Cell ◽  
Radical Nephrectomy ◽  
Tumor Thrombus ◽  
Cancer Specific Survival ◽  
Venous Tumor Thrombus

Introduction. To evaluate the prognostic outcomes and risk factors for renal cell carcinoma (RCC) patients with venous tumor thrombus in China.Materials and Methods. We reviewed the clinical information of 169 patients who underwent radical nephrectomy and thrombectomy. Overall and cancer-specific survival rates were analyzed. Univariate and multivariate analyses were used to investigate the potential prognostic factors.Results. The median survival time was 63 months. The five-year overall survival and cancer-specific survival rate were 53.6% and 54.4% for all patients. For all patients, significant survival difference was only observed between early (below hepatic vein) and advanced (above hepatic vein) tumor thrombus. However, significant differences existed between both RV/IVC and early/advanced tumor thrombus groups in N0M0 patients. Multivariate analysis demonstrated that higher tumor thrombus level (p=0.016,RR=1.58), N (p=0.013,RR=2.60), and M (p<0.001,RR=4.14) stages and adrenal gland invasion (p=0.001,RR=4.91) were the most significant negative prognostic predictors.Conclusions. In this study, we reported most cases of RCC patients with venous extension in China. We proved that patients with RCC and venous tumor thrombus may have relative promising long-term survival rate, especially those with early tumor thrombus.

Risk factors for locoregional relapse after transoral robotic surgery for human papillomavirus-related oropharyngeal squamous cell carcinoma

Head & Neck ◽  
2015 ◽  
Vol 38 (S1) ◽  
pp. E1674-E1679 ◽  
Author(s):  
Ryan K. Funk ◽  
Eric J. Moore ◽  
Joaquín J. García ◽  
W. Scott Harmsen ◽  
David G. Stoddard ◽  
...  
Keyword(s):  
Risk Factors ◽  
Squamous Cell Carcinoma ◽  
Human Papillomavirus ◽  
Robotic Surgery ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Transoral Robotic Surgery ◽  
Oropharyngeal Squamous Cell Carcinoma ◽  
Locoregional Relapse
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