Association between single nucleotide polymorphism ofPD-L1gene and non-small cell lung cancer susceptibility in a Chinese population

2012 ◽  
Vol 10 (2) ◽  
pp. e1-e6 ◽  
Author(s):  
Yan-bin Chen ◽  
Chuan-yong Mu ◽  
Cheng Chen ◽  
Jian-An Huang
Keyword(s):  
Lung Cancer ◽  
Single Nucleotide Polymorphism ◽  
Small Cell Lung Cancer ◽  
Chinese Population ◽  
Cancer Susceptibility ◽  
Small Cell ◽  
Nucleotide Polymorphism ◽  
Small Cell Lung ◽  
Single Nucleotide ◽  
Lung Cancer Susceptibility

Single Nucleotide Polymorphisms in VTI1A Gene Contribute to the Susceptibility of Chinese Population to Non-Small Cell Lung cancer

2015 ◽  
Vol 30 (3) ◽  
pp. 286-293 ◽  
Author(s):  
Wen-Mei Su ◽  
Zhi-Hong Chen ◽  
Xu-Chao Zhang ◽  
Jian Su ◽  
Zhi Xie ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Chinese Population ◽  
Cancer Susceptibility ◽  
Small Cell ◽  
Adiponectin Receptor ◽  
Genome Wide Association Studies ◽  
Small Cell Lung ◽  
Single Nucleotide ◽  
Adiponectin Receptor 1 ◽  
Lung Cancer Susceptibility

Background Genome-wide association studies (GWAS) have determined a new single nucleotide polymorphism (SNP) called VTI1A (rs7086803) that induces lung cancer susceptibility in nonsmoking women in Asia. This study aimed to evaluate the association between the VTI1A gene and the susceptibility of Chinese patients to lung cancer; it was also conducted to investigate the relationship between VTI1A SNP and adiponectin receptor 1 expression. Methods A total of 887 subjects were enrolled in this study. VTI1A (rs7086803) genotypes were determined by genotyping. Overall survival (OS) was evaluated using Kaplan-Meier analysis with a log-rank test. Results Multivariate regression analysis results indicated that the AA genotype of VTI1A (rs7086803) polymorphism was associated with an increased risk of developing non-small cell lung carcinoma (NSCLC) compared with the GG genotype (AA vs. GG: odds ratio [OR] = 2.020; 95% confidence interval [95% CI], 1.033-3.949, p = 0.037). The AA genotype of VTI1A (rs7086803) in smokers predicted significantly shorter OS (median survival time [MST]: AA 9.8 months, AG 19.3 months, GG 12.2 months, p = 0.017). Adiponectin receptor 1 expression in tumor tissues with the AA genotype was significantly lower than that for other genotypes (mean rank: AA 18.55, AG 25, GG 45.76, p = 0.001). Conclusions The presence of the allele A of VTI1A (rs7086803) may be the allele contributing to the risk of lung cancer susceptibility in Chinese population. Smoking lung cancer patients with the AA genotype of VTI1A gene (rs7086803) had a poor survival rate. Adiponectin receptor 1 expression may be correlated with the susceptibility of the allele A of VTI1A.

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