Persistence of Operant Responding for Food After Prior Cocaine Exposure in Fischer 344 But Not Lewis Rats

2021 ◽  
Author(s):  
Shadab Forouzan ◽  
Steven J. Nieto ◽  
Therese A. Kosten
Keyword(s):  
Cocaine Exposure ◽  
Lewis Rats ◽  
Operant Responding ◽  
Fischer 344

Assessment of the aversive effects of peripheral mu opioid receptor agonism in Fischer 344 and Lewis rats

2012 ◽  
Vol 101 (2) ◽  
pp. 181-186 ◽  
Author(s):  
Catherine M. Davis ◽  
Jennifer L. Cobuzzi ◽  
Anthony L. Riley
Keyword(s):  
Opioid Receptor ◽  
Mu Opioid Receptor ◽  
Lewis Rats ◽  
Mu Opioid ◽  
Fischer 344

Prepubertal Fischer 344 rats display stronger morphine-induced taste avoidance than prepubertal Lewis rats

2013 ◽  
Vol 56 (5) ◽  
pp. 979-988 ◽  
Author(s):  
Zachary E. Hurwitz ◽  
Jennifer L. Cobuzzi ◽  
Andrew P. Merluzzi ◽  
Bradley Wetzell ◽  
Anthony L. Riley
Keyword(s):  
Fischer 344 Rats ◽  
Lewis Rats ◽  
Taste Avoidance ◽  
Fischer 344

Genetic differences in NMDA and D1 receptor levels, and operant responding for food and morphine in Lewis and Fischer 344 rats

2003 ◽  
Vol 973 (2) ◽  
pp. 205-213 ◽  
Author(s):  
Sonsoles Martı́n ◽  
Yulia Lyupina ◽  
José Antonio Crespo ◽  
Begoña González ◽  
Carmen Garcı́a-Lecumberri ◽  
...  
Keyword(s):  
Genetic Differences ◽  
D1 Receptor ◽  
Fischer 344 Rats ◽  
Operant Responding ◽  
Fischer 344

Adolescent Fischer 344 and Lewis rats differ in morphine-induced taste aversions

2014 ◽  
Vol 140 ◽  
pp. e93-e94
Author(s):  
Zachary E. Hurwitz ◽  
Jennifer L. Cobuzzi ◽  
Bradley Wetzell ◽  
A.P. Merluzzi ◽  
A.L. Riley
Keyword(s):  
Lewis Rats ◽  
Fischer 344

scholarly journals Striatal Nurr1 Facilitates the Dyskinetic State and Exacerbates Levodopa-Induced Dyskinesia in a Rat Model of Parkinson’s Disease

2019 ◽  
Author(s):  
RC Sellnow ◽  
K Steece-Collier ◽  
F Altwal ◽  
IM Sandoval ◽  
JH Kordower ◽  
...  
Keyword(s):  
Causative Factor ◽  
Spine Density ◽  
Direct Role ◽  
Lewis Rats ◽  
Fischer 344 ◽  
Therapeutic Development ◽  
Drug Naïve ◽  
Novel Target ◽  
F344 Rats

AbstractBackgroundThe transcription factor Nurr1 has been identified to be ectopically induced in the striatum of dyskinetic rodents expressing L-DOPA-induced dyskinesia (LID). In the present study, we sought to characterize Nurr1 as a causative factor in LID expression.MethodsWe used rAAV2/5 to overexpress Nurr1 or GFP in the parkinsonian striatum of LID-resistant Lewis or LID-prone Fischer-344 (F344) rats. In a second cohort, rats received the Nurr1 agonist amodiaquine (AQ) together with L-DOPA or ropinirole. All rats received a chronic DA agonist and were evaluated for LID severity. Finally, we performed single unit recordings and dendritic spine analyses in drug-naïve rAAV-injected parkinsonian rats.ResultsrAAV-GFP injected LID-resistant Lewis rats displayed mild LID and no induction of striatal Nurr1. However, Lewis rats transduced to overexpress Nurr1 developed severe LID. Nurr11 agonism with AQ exacerbated LID in F344 rats. We additionally determined that in L-DOPA-naïve rats striatal rAAV-Nurr1 overexpression 1) increased firing activity in dopamine-depleted striatal direct pathway neurons, and 2) decreased spine density and thin-spine morphology on striatal medium spiny neurons, mimicking changes seen in dyskinetic rats. Finally, we provide post-mortem evidence of Nurr1 expression in the striatum of L-DOPA treated PD patients.ConclusionsOur data demonstrate that ectopic induction of striatal Nurr1 is capable of inducing LID behavior and associated neuropathology, even in resistant subjects. These data support a direct role of Nurr1 in aberrant neuronal plasticity and LID induction, providing a potential novel target for therapeutic development.

Strain differences in mesotelencephalic dopaminergic neuronal regulation between Fischer 344 and Lewis rats

1999 ◽  
Vol 832 (1-2) ◽  
pp. 152-158 ◽  
Author(s):  
Steven E Lindley ◽  
Tasha G Bengoechea ◽  
Dona L Wong ◽  
Alan F Schatzberg
Keyword(s):  
Strain Differences ◽  
Lewis Rats ◽  
Fischer 344 ◽  
Neuronal Regulation
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