scholarly journals Transition of Patients with Opioid Use Disorder from Buprenorphine to Extended‐Release Naltrexone: A Randomized Clinical Trial Assessing Two Transition Regimens

2020 ◽  
Vol 29 (4) ◽  
pp. 313-322 ◽  
Author(s):  
Sandra D. Comer ◽  
Paolo Mannelli ◽  
Danesh Alam ◽  
Antoine Douaihy ◽  
Narinder Nangia ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Extended Release ◽  
Opioid Use Disorder ◽  
Opioid Use

Cost-effectiveness of hydromorphone for severe opioid use disorder: findings from the SALOME randomized clinical trial

Addiction ◽  
2018 ◽  
Vol 113 (7) ◽  
pp. 1264-1273 ◽  
Author(s):  
Nick Bansback ◽  
Daphne Guh ◽  
Eugenia Oviedo-Joekes ◽  
Suzanne Brissette ◽  
Scott Harrison ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Cost Effectiveness ◽  
Randomized Clinical Trial ◽  
Opioid Use Disorder ◽  
Opioid Use

scholarly journals Support Models for Addiction Related Treatment (SMART) for pregnant women: Study protocol of a cluster randomized trial of two treatment models for opioid use disorder in prenatal clinics

PLoS ONE ◽  
2022 ◽  
Vol 17 (1) ◽  
pp. e0261751
Author(s):  
Ariadna Forray ◽  
Amanda Mele ◽  
Nancy Byatt ◽  
Amalia Londono Tobon ◽  
Kathryn Gilstad-Hayden ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Pregnant Women ◽  
Randomized Clinical Trial ◽  
Opioid Use Disorder ◽  
Trial Registration ◽  
Patient Treatment ◽  
Matched Pair ◽  
Prescribe Medication ◽  
Opioid Use ◽  
Cluster Randomized

Introduction The prevalence of opioid use disorder (OUD) in pregnancy increased nearly five-fold over the past decade. Despite this, obstetric providers are less likely to treat pregnant women with medication for OUD than non-obstetric providers (75% vs 91%). A major reason is many obstetricians feel unprepared to prescribe medication for opioid use disorder (MOUD). Education and support may increase prescribing and overall comfort in delivering care for pregnant women with OUD, but optimal models of education and support are yet to be determined. Methods and analysis We describe the rationale and conduct of a matched-pair cluster randomized clinical trial to compare the effectiveness of two models of support for reproductive health clinicians to provide care for pregnant and postpartum women with OUD. The primary outcomes of this trial are patient treatment engagement and retention in OUD treatment. This study compares two support models: 1) a collaborative care approach, based upon the Massachusetts Office-Based-Opioid Treatment Model, that provides practice-level training and support to providers and patients through the use of care managers, versus 2) a telesupport approach based on the Project Extension for Community Healthcare Outcomes, a remote education model that provides mentorship, guided practice, and participation in a learning community, via video conferencing. Discussion This clustered randomized clinical trial aims to test the effectiveness of two approaches to support practitioners who care for pregnant women with an OUD. The results of this trial will help determine the best model to improve the capacity of obstetrical providers to deliver treatment for OUD in prenatal clinics. Trial registration Clinicaltrials.gov trial registration number: NCT0424039.

Initiating buprenorphine treatment for opioid use disorder during short‐term in‐patient ‘detoxification’: a randomized clinical trial

Addiction ◽  
2019 ◽  
Vol 115 (1) ◽  
pp. 82-94 ◽  
Author(s):  
Michael Stein ◽  
Debra Herman ◽  
Micah Conti ◽  
Bradley Anderson ◽  
Genie Bailey
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Opioid Use Disorder ◽  
Opioid Use ◽  
Short Term ◽  
Buprenorphine Treatment
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