Survey of nuclear progesterone receptor expression in the uterus of the cyclic and pregnant camel (Camelus dromedarius )

2018 ◽  
Vol 47 (6) ◽  
pp. 544-550
Author(s):  
Abdel-Hamid K. Osman ◽  
Louise C. Abbott ◽  
Amal A. M. Ahmed
Keyword(s):  
Progesterone Receptor ◽  
Receptor Expression ◽  
Camelus Dromedarius ◽  
Progesterone Receptor Expression ◽  
Nuclear Progesterone Receptor

scholarly journals Progesterone stimulates mitochondrial activity with subsequent inhibition of apoptosis in MCF-10A benign breast epithelial cells

2009 ◽  
Vol 297 (5) ◽  
pp. E1089-E1096 ◽  
Author(s):  
Millie A. Behera ◽  
Qunsheng Dai ◽  
Rachana Garde ◽  
Carrie Saner ◽  
Emily Jungheim ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Progesterone Receptor ◽  
Receptor Expression ◽  
Growth Effect ◽  
Mitochondrial Activity ◽  
Progesterone Receptor Expression ◽  
Breast Epithelial Cells ◽  
Progestin Treatment ◽  
Breast Epithelial ◽  
Nuclear Progesterone Receptor

The effects of progesterone on breast epithelial cells remain poorly defined with observations showing both proliferative and antiproliferative effects. As an example, progesterone levels correlate with increased epithelial cell proliferation, but there is discordance between the dividing cells and the cells with nuclear progesterone receptor expression. The release of paracrine growth factors from nuclear receptor-positive cells has been postulated as a mechanism, since in vitro studies show a lack of growth effect by progesterone in breast epithelial cells lacking nuclear receptors. This study examined possible nongenomic effects of progesterone in breast epithelia by using MCF-10A cells known to lack nuclear progesterone receptor expression. Treatment for 30–60 min with progesterone or the progestin, R5020, increased mitochondrial activity as shown by an increase in mitochondrial membrane potential (hyperpolarization) with a concordant increase in total cellular ATP. The reaction was inhibited by a specific progesterone receptor antagonist and not affected by the translation inhibitor cycloheximide. Progestin treatment inhibited apoptosis induced by activation of the FasL pathway, as shown by a decrease in sub-G1 cell fraction during fluorescence-activated cell sorting and a decrease in caspase 3/7 levels. Progestin treatment did not alter the cell cycle over 48 h. Our study demonstrates a nongenomic action of progesterone on benign breast epithelial cells, resulting in enhanced cellular respiration and protection from apoptosis.

scholarly journals Sex-specific modification of progesterone receptor expression by 17β-oestradiol in human cardiac tissues

2010 ◽  
Vol 1 (1) ◽  
pp. 2 ◽  
Author(s):  
Georgios Kararigas ◽  
Eva Becher ◽  
Shokoufeh Mahmoodzadeh ◽  
Christoph Knosalla ◽  
Roland Hetzer ◽  
...  
Keyword(s):  
Progesterone Receptor ◽  
Receptor Expression ◽  
Progesterone Receptor Expression ◽  
Cardiac Tissues ◽  
Specific Modification

Prognostic value of progesterone receptor expression in tubo-ovarian high-grade serous carcinoma of the COEUR cohort

2019 ◽  
Vol 74 (4) ◽  
pp. 663-666 ◽  
Author(s):  
Cécile Le Page ◽  
Kurosh Rahimi ◽  
Anne-Marie Mes-Masson ◽  
Martin Köbel
Keyword(s):  
Progesterone Receptor ◽  
Prognostic Value ◽  
Receptor Expression ◽  
Serous Carcinoma ◽  
High Grade ◽  
Progesterone Receptor Expression
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