Innervation of Extrahepatic Biliary Tract, With Special Reference to the Direct Bidirectional Neural Connections of the Gall Bladder, Sphincter of Oddi and Duodenum inSuncus murinus, in Whole-Mount Immunohistochemical Study

2015 ◽  
Vol 45 (3) ◽  
pp. 184-188 ◽  
Author(s):  
S.-Q. Yi ◽  
K. Ren ◽  
M. Kinoshita ◽  
N. Takano ◽  
M. Itoh ◽  
...  
Keyword(s):  
Gall Bladder ◽  
Special Reference ◽  
Biliary Tract ◽  
Immunohistochemical Study ◽  
Sphincter Of Oddi ◽  
Neural Connections ◽  
Whole Mount

scholarly journals Trimebutine maleate in the treatment of functional biliary disorders: TRIBUNE study results

2019 ◽  
pp. 117-125
Author(s):  
V. T. Ivashkin ◽  
Ch. S. Pavlov ◽  
I. R. Popova ◽  
Yu. O. Shulpekova
Keyword(s):  
Gall Bladder ◽  
Biliary Tract ◽  
Bile Ducts ◽  
Sphincter Of Oddi ◽  
Functional Disorders ◽  
Biliary Pain ◽  
Standard Dosage ◽  
Trimebutine Maleate ◽  
Study Results ◽  
Rome Iv

Introduction. The term «functional disorders of the biliary tract and bile ducts» defines the conditions, which produce typical patterns of biliary pains in the absence of obvious signs of organic lesions of the gallbladder and bile ducts. The materials of the Rome IV consensus present the diagnostic criteria of their main types – functional disorders of the gall bladder and sphincter of Oddi. Vasilenko Clinic of Internal Diseases Propedeutics, Gastroenterology and Hepatology of the University Clinical Hospital No. 2 of Sechenov University carried out a noninterventional observational program to study the experience in using Trimedat® (trimebutine maleate) in the routine outpatient and inpatient practice in the treatment of patients with functional diseases of the biliary tract. Information partners of the program are the Russian Gastroenterological Association (RGA) and the Russian Society for the Study of the Liver (RSSL).Materials and methods. The program included patients of both sexes aged 18 to 65 years with ICD-10 diagnoses «spasm of the sphincter of Oddi» (K 83.4), «postcholecystectomy syndrome» (K 91.5), «other specified diseases of the gallbladder» (K 82.8) , «other specified diseases of the bile ducts» (K 83.8), «disorders of gallbladder and biliary tract in diseases classified elsewhere» (K 87.0), if the clinical picture was consistent with functional biliary disorders according to the Rome IV criteria and in cases when the doctor decided to prescribe Trimedat® therapy. Patients were observed for 28 ± 1 days. The dynamics of biliary pain and discomfort, as well as other symptoms (in particular, nausea, flatulence) were evaluated on the background of the therapy, using the Gastrointestinal Symptom Score Scale, in which the severity of each symptom is estimated by 7 grades (Alekseev N.Yu., 2006) with adding a section to evaluate the biliary disorders. In the presence of criteria for functional disorders of the gallbladder, an ultrasound control of the fraction of its discharge was carried out before and after the therapy.Results. 100 patients (33 (33%) men and 67 (67%) women, the average age 42.2 ± 13.2 years (18–65 years)) were enrolled in the program. In accordance with the Rome IV Consensus, the majority of patients (83 (83%)) had the functional disorders of GB; in 16 (16%) patients with the removed GB, the picture corresponded to the functional disorder of SO, one patient with kept GB was diagnosed with SO dysfunction. The treatment with Trimedate® at a standard dosage resulted in a decrease in the proportion of pain in the epigastric region (in the Scale section evaluating the biliary tract symptoms), the degree of nausea and bloating. Differences between the visits were estimated by the Friedman’s test, p <0.001. In addition, other sections of the scale also showed a decrease in indicators in scores. 79 patients underwent repeated ultrasound cholecystography at the end of treatment. It showed an increase in the fraction of GB emptying.Conclusions. The use of Trimedate® in patients with functional disorders of the gall bladder and sphincter of Oddi resulted in the reduction of the severity of the main symptoms - the severity of biliary pain, nausea, bloating. The patients with GB dysfunction showed an increase in the fraction of GB emptying.

The Sphincter of Oddi is a Boundary for Bacterial Colonisation in the Feline Biliary Tract

1990 ◽  
Vol 3 (4) ◽  
Author(s):  
J. Y. Sung ◽  
M. E. Olson ◽  
J. W. C. Leung ◽  
M. S. Lundberg ◽  
J. W. Costerton
Keyword(s):  
Biliary Tract ◽  
Sphincter Of Oddi ◽  
Bacterial Colonisation

Biliary tract dysmotility and sphincter of Oddi dyskinesia

1997 ◽  
Vol 50 (4) ◽  
pp. 174-179
Author(s):  
G VANBERGEHENEGOUWEN ◽  
M SAMSON ◽  
A SMOUT
Keyword(s):  
Biliary Tract ◽  
Sphincter Of Oddi

scholarly journals Acute renal failure caused by ingestion of the carp gall bladder - A report of 3 cases with a special reference to the reported cases in Japan.

1988 ◽  
Vol 77 (8) ◽  
pp. 1268-1273 ◽  
Author(s):  
Yoshitaka YAMAMOTO ◽  
Osamu WAKISAKA ◽  
Shoichi FUJIMOTO ◽  
Nobuhiro KASEDA ◽  
Tadahiko MAEHARA ◽  
...  
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Gall Bladder ◽  
Special Reference

Duodenal neurons provide nicotinic fast synaptic input to sphincter of Oddi neurons in guinea pig

1999 ◽  
Vol 277 (1) ◽  
pp. G226-G234 ◽  
Author(s):  
Gary M. Mawe ◽  
Audra L. Kennedy
Keyword(s):  
Synaptic Input ◽  
Sphincter Of Oddi ◽  
Duodenal Mucosa ◽  
Postsynaptic Potentials ◽  
Chemical Coding ◽  
Neural Connections ◽  
Inhibitory Postsynaptic Potentials ◽  
Neural Communication ◽  
Antidromic Responses ◽  
Synaptic Responses

We have investigated the existence of neural connections between the duodenum and the sphincter of Oddi (SO). Stimulation of duodenal myenteric fiber bundles elicited synaptic responses in SO neurons, which included nicotinic fast excitatory postsynaptic potentials (EPSPs), slow EPSPs, and α2-adrenoreceptor-mediated inhibitory postsynaptic potentials. After 48 h in organ culture, when extrinsic fibers had diminished, only the fast EPSPs persisted. Duodenal mucosal stimulation also elicited nicotinic fast EPSPs in SO neurons. There was no association between the SO neurons that received duodenal input and their chemical coding. A reciprocal projection also exists from the SO to the duodenum. In acute and cultured preparations, duodenal myenteric stimulation caused antidromic responses in 20% of SO neurons. Furthermore, 45.6 ± 10.5 neurons in SO ganglia were retrogradely labeled from dye application sites in the duodenum. It is proposed that bidirectional neural communication occurs between the duodenum and the SO and that duodenal neurons provide excitatory fast synaptic input to SO neurons through a reflex that can be activated at the duodenal mucosa.

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