A deletion in the MC1R gene alters coat color in Guzerat cattle

2021 ◽  
Author(s):  
Carolaine Jesus Silva Santana ◽  
Jackeline Santos Alves ◽  
Luís Fernando Batista Pinto ◽  
Raphael Bermal Costa ◽  
Gregório Miguel Ferreira Camargo
Keyword(s):  
Coat Color ◽  
Mc1r Gene

scholarly journals High Polymorphism at the Human Melanocortin 1 Receptor Locus

Genetics ◽  
1999 ◽  
Vol 151 (4) ◽  
pp. 1547-1557 ◽  
Author(s):  
Brinda K Rana ◽  
David Hewett-Emmett ◽  
Li Jin ◽  
Benny H-J Chang ◽  
Naymkhishing Sambuughin ◽  
...  
Keyword(s):  
Protein Sequence ◽  
Nucleotide Diversity ◽  
Coat Color ◽  
Low Frequency ◽  
Melanocortin Receptor ◽  
Human Populations ◽  
Melanocortin 1 Receptor ◽  
Mc1r Gene ◽  
Southeast Asians ◽  
Color Changes

Abstract Variation in human skin/hair pigmentation is due to varied amounts of eumelanin (brown/black melanins) and phaeomelanin (red/yellow melanins) produced by the melanocytes. The melanocortin 1 receptor (MC1R) is a regulator of eu- and phaeomelanin production in the melanocytes, and MC1R mutations causing coat color changes are known in many mammals. We have sequenced the MC1R gene in 121 individuals sampled from world populations with an emphasis on Asian populations. We found variation at five nonsynonymous sites (resulting in the variants Arg67Gln, Asp84Glu, Val92Met, Arg151Cys, and Arg163Gln), but at only one synonymous site (A942G). Interestingly, the human consensus protein sequence is observed in all 25 African individuals studied, but at lower frequencies in the other populations examined, especially in East and Southeast Asians. The Arg163Gln variant is absent in the Africans studied, almost absent in Europeans, and at a low frequency (7%) in Indians, but is at an exceptionally high frequency (70%) in East and Southeast Asians. The MC1R gene in common and pygmy chimpanzees, gorilla, orangutan, and baboon was sequenced to study the evolution of MC1R. The ancestral human MC1R sequence is identical to the human consensus protein sequence, while MC1R varies considerably among higher primates. A comparison of the rates of substitution in genes in the melanocortin receptor family indicates that MC1R has evolved the fastest. In addition, the nucleotide diversity at the MC1R locus is shown to be several times higher than the average nucleotide diversity in human populations, possibly due to diversifying selection.

MC1R gene and coat color in buffaloes

2020 ◽  
Vol 51 (2) ◽  
pp. 345-346
Author(s):  
Valdecy Aparecida Rocha da Cruz ◽  
Jackeline Santos Alves ◽  
Marisa Silva Bastos ◽  
Louise Sarmento Martins Oliveira ◽  
Iara Del Pilar Solar Diaz ◽  
...  
Keyword(s):  
Coat Color ◽  
Mc1r Gene

scholarly journals The Association of MC1R Gene with Coat Color of Banna Mini-Pig Inbred Line (BMI)

2012 ◽  
Vol 11 (4) ◽  
pp. 503-508 ◽  
Author(s):  
Xiao Heng ◽  
Huo Jinlong ◽  
Huo Hailong ◽  
Wang Pei ◽  
Zeng Yangzhi
Keyword(s):  
Inbred Line ◽  
Coat Color ◽  
Mc1r Gene

scholarly journals Evaluation of Coat Color Inheritance and Production Performance for Cossbreed from Chinese Indigenous Chenghua Pig Crossbred with Berkshire

2020 ◽  
Author(s):  
Xue Wang ◽  
Zhengyin Gong ◽  
Qin Zou ◽  
Li Zhu ◽  
Guoqing Tang ◽  
...  
Keyword(s):  
Meat Quality ◽  
Coat Color ◽  
Live Weight ◽  
Production Performance ◽  
Quality Characteristic ◽  
Total Production ◽  
Poor Growth ◽  
Mc1r Gene ◽  
Indigenous Breed ◽  
Longissimus Lumborum

Abstract Background: Crossbreeding programs have been used extensively to improve the native pig’s overall production performance while maintaining superior meat quality. Chenghua (CH) pig is a traditional Chinese indigenous breed with superior meat quality characteristic but poor growth and carcass traits. In recent years, we implemented Berkshire × Chenghua (BC) crossbreeding scheme and have bred the new crossbreed BC pig through selection for four generations. The present objective was to determine the black coat inheritance and evaluate production performance for crossbreed BC F4 pigs in comparison with those of control purebred CH pigs. Results: Coat color of crossbreed BC pigs exhibits a “dominant black” hereditary pattern. Twelve mutation sites for MC1R gene were identified between “uniform black type” and “domino black spotting type” pigs and all piglets derived from boars or sows genotyped ED1ED1 homozygous for MC1R gene showed uniform black coat phenotype. The crossbreed BC F4 gilts displayed a relatively good reproductive performance, showing a higher litter (total no. born: 12.06 and no. born alive: 11.14) and tear size (13.14), heavier at farrowing litter (11.92 kg) and at weaning litter (65.87 kg) than purebred CH gilts, but they reached puberty later than CH gilts (178.44 vs.125.45). The crossbreed BC F4 pigs exhibited improved growth and carcass characteristics with a higher average daily live weight gain (535.28 g vs. 447.11 g), lower feed-to-gain ratio (3.06 vs. 4.03), and higher carcass lean meat rate (50.76% vs. 42.58%) than purebred CH pigs. Importantly, similar to those of purebred CH pigs, the crossbreed BC F4 pigs produced super meat-quality characteristics, showing ideal pH and meat-color values, high intramuscular fat content (3.24%) and water-holding capacity (drip loss: 1.68%), and acceptable muscle-fibre parameters. C18:1, C16:0, C18:0, and C18:2 were the main fatty acids in M. longissimus lumborum in the two breeds, and a very high polyunsaturated/saturated fatty acid ratio of ~0.39 was observed in the BC F4 pigs. Conclusion: These results indicate that crossbreed BC F4 pigs exhibit a uniform black coat pattern and acceptable total production performance, and it can be extensively used in commercial pig production to provide high-quality niche products.

The role of MC1R gene in buffalo coat color

2010 ◽  
Vol 53 (2) ◽  
pp. 267-272 ◽  
Author(s):  
YongWang Miao ◽  
GuiSheng Wu ◽  
Lei Wang ◽  
DaLin Li ◽  
ShouKun Tang ◽  
...  
Keyword(s):  
Coat Color ◽  
Mc1r Gene
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