Genome‐wide association study identifies energy metabolism genes for resistance to ketosis in Chinese Holstein cattle

2019 ◽  
Vol 50 (4) ◽  
pp. 376-380 ◽  
Author(s):  
H. Huang ◽  
J. Cao ◽  
Q. Hanif ◽  
Y. Wang ◽  
Y. Yu ◽  
...  
Keyword(s):  
Energy Metabolism ◽  
Association Study ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Holstein Cattle ◽  
Chinese Holstein ◽  
Genome Wide ◽  
Chinese Holstein Cattle

scholarly journals Genome-Wide Association Study Candidate Genes on Mammary System-Related Teat-Shape Conformation Traits in Chinese Holstein Cattle

Genes ◽  
2021 ◽  
Vol 12 (12) ◽  
pp. 2020
Author(s):  
Mudasir Nazar ◽  
Xubin Lu ◽  
Ismail Mohamed Abdalla ◽  
Numan Ullah ◽  
Yongliang Fan ◽  
...  
Keyword(s):  
Association Study ◽  
Candidate Genes ◽  
Genetic Architecture ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Holstein Cattle ◽  
Dairy Production ◽  
Chinese Holstein ◽  
Genome Wide ◽  
Chinese Holstein Cattle

In the dairy industry, mammary system traits are economically important for dairy animals, and it is important to explain their fundamental genetic architecture in Holstein cattle. Good and stable mammary system-related teat traits are essential for producer profitability in animal fitness and in the safety of dairy production. In this study, we conducted a genome-wide association study on three traits—anterior teat position (ATP), posterior teat position (PTP), and front teat length (FTL)—in which the FarmCPU method was used for association analyses. Phenotypic data were collected from 1000 Chinese Holstein cattle, and the GeneSeek Genomic Profiler Bovine 100K single-nucleotide polymorphisms (SNP) chip was used for cattle genotyping data. After the quality control process, 984 individual cattle and 84,406 SNPs remained for GWAS work analysis. Nine SNPs were detected significantly associated with mammary-system-related teat traits after a Bonferroni correction (p < 5.92 × 10−7), and genes within a region of 200 kb upstream or downstream of these SNPs were performed bioinformatics analysis. A total of 36 gene ontology (GO) terms and 3 Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways were significantly enriched (p < 0.05), and these terms and pathways are mainly related to metabolic processes, immune response, and cellular and amino acid catabolic processes. Eleven genes including MMS22L, E2F8, CSRP3, CDH11, PEX26, HAL, TAMM41, HIVEP3, SBF2, MYO16 and STXBP6 were selected as candidate genes that might play roles in the teat traits of cows. These results identify SNPs and candidate genes that give helpful biological information for the genetic architecture of these teat traits, thus contributing to the dairy production, health, and genetic selection of Chinese Holstein cattle.

scholarly journals GENOME-WIDE ASSOCIATION STUDY FOR MILK PRODUCTION AND REPRODUCTION TRAITS IN RUSSIAN HOLSTEIN CATTLE POPULATION

2016 ◽  
Vol 51 (2) ◽  
pp. 182-193 ◽  
Author(s):  
A.A. Sermyagin A.A. Sermyagin ◽  
◽  
E.A. Gladyr’ E.A. Gladyr’ ◽  
S.N. Kharitonov S.N. Kharitonov ◽  
A.N. Ermilov A.N. Ermilov ◽  
...  
Keyword(s):  
Association Study ◽  
Milk Production ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Holstein Cattle ◽  
Cattle Population ◽  
Genome Wide ◽  
Reproduction Traits

0329 Genome-wide association study for loci associated with digital dermatitis and pododermatitis circumscripta in Holstein cattle

2016 ◽  
Vol 94 (suppl_5) ◽  
pp. 158-158 ◽  
Author(s):  
A. M. Oberbauer ◽  
A. L. Danner ◽  
J. M. Belanger ◽  
T. R. Famula ◽  
J. M. Heguy
Keyword(s):  
Association Study ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Holstein Cattle ◽  
Digital Dermatitis ◽  
Genome Wide

scholarly journals A Large-Scale Genome-Wide Association Study in U.S. Holstein Cattle

2019 ◽  
Vol 10 ◽  
Author(s):  
Jicai Jiang ◽  
Li Ma ◽  
Dzianis Prakapenka ◽  
Paul M. VanRaden ◽  
John B. Cole ◽  
...  
Keyword(s):  
Association Study ◽  
Large Scale ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Holstein Cattle ◽  
Genome Wide
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