Association of single nucleotide polymorphisms in the microRNAmiR-1596locus with residual feed intake in chickens

2015 ◽  
Vol 46 (3) ◽  
pp. 265-271 ◽  
Author(s):  
C. Luo ◽  
L. Sun ◽  
J. Ma ◽  
J. Wang ◽  
H. Qu ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphisms ◽  
Feed Intake ◽  
Residual Feed Intake ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide

Candidate genes and single nucleotide polymorphisms associated with variation in residual feed intake in beef cattle1

2013 ◽  
Vol 91 (8) ◽  
pp. 3502-3513 ◽  
Author(s):  
B. K. Karisa ◽  
J. Thomson ◽  
Z. Wang ◽  
P. Stothard ◽  
S. S. Moore ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphisms ◽  
Candidate Genes ◽  
Feed Intake ◽  
Residual Feed Intake ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide

scholarly journals FABP4is a leading candidate gene associated with residual feed intake in growing Holstein calves

2016 ◽  
Vol 48 (5) ◽  
pp. 367-376 ◽  
Author(s):  
Miri Cohen-Zinder ◽  
Aviv Asher ◽  
Ehud Lipkin ◽  
Roi Feingersch ◽  
Rotem Agmon ◽  
...  
Keyword(s):  
Feed Intake ◽  
Scale Validation ◽  
Residual Feed Intake ◽  
Significant Snps ◽  
Nucleotide Polymorphisms ◽  
Special Equipment ◽  
Single Nucleotide ◽  
Fatty Acid Binding ◽  
Holstein Breed ◽  
Holstein Calves

Ecological and economic concerns drive the need to improve feed utilization by domestic animals. Residual feed intake (RFI) is one of the most acceptable measures for feed efficiency (FE). However, phenotyping RFI-related traits is complex and expensive and requires special equipment. Advances in marker technology allow the development of various DNA-based selection tools. To assimilate these technologies for the benefit of RFI-based selection, reliable phenotypic measures are prerequisite. In the current study, we identified single nucleotide polymorphisms (SNPs) associated with RFI phenotypic consistency across different ages and diets (named RFI 1–3), using DNA samples of high or low RFI ranked Holstein calves. Using targeted sequencing of chromosomal regions associated with FE- and RFI-related traits, we identified 48 top SNPs significantly associated with at least one of three defined RFIs. Eleven of these SNPs were harbored by the fatty acid binding protein 4 ( FABP4). While 10 significant SNPs found in FABP4 were common for RFI 1 and RFI 3, one SNP (FABP4_5; A<G substitution), in the promoter region of the gene, was significantly associated with all three RFIs. As the three RFI classes reflect changing diets and ages with concomitant RFI phenotypic consistency, the above polymorphisms and in particular FABP4_5, might be considered possible markers for RFI-based selection for FE in the Holstein breed, following a larger-scale validation.

Development of a simple method for the determination of single nucleotide polymorphisms

2010 ◽  
Vol 34 (8) ◽  
pp. S75-S75
Author(s):  
Weifeng Zhu ◽  
Zhuoqi Liu ◽  
Daya Luo ◽  
Xinyao Wu ◽  
Fusheng Wan
Keyword(s):  
Single Nucleotide Polymorphisms ◽  
Nucleotide Polymorphisms ◽  
Simple Method ◽  
Single Nucleotide

Sex Differences in Childhood Associations between DNA Markers and General Cognitive Ability

2007 ◽  
Vol 28 (3) ◽  
pp. 161-164 ◽  
Author(s):  
Rosalind Arden ◽  
Nicole Harlaar ◽  
Robert Plomin
Keyword(s):  
Sex Differences ◽  
Single Nucleotide Polymorphisms ◽  
Cognitive Ability ◽  
Dna Markers ◽  
Community Sample ◽  
Nucleotide Polymorphisms ◽  
General Cognitive Ability ◽  
Single Nucleotide ◽  
The Difference

Abstract. An association between intelligence at age 7 and a set of five single-nucleotide polymorphisms (SNPs) has been identified and replicated. We used this composite SNP set to investigate whether the associations differ between boys and girls for general cognitive ability at ages 2, 3, 4, 7, 9, and 10 years. In a longitudinal community sample of British twins aged 2-10 (n > 4,000 individuals), we found that the SNP set is more strongly associated with intelligence in males than in females at ages 7, 9, and 10 and the difference is significant at 10. If this finding replicates in other studies, these results will constitute the first evidence of the same autosomal genes acting differently on intelligence in the two sexes.

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