New insights into polar overdominance in callipyge sheep

2014 ◽  
Vol 45 ◽  
pp. 51-61 ◽  
Author(s):  
C. A. Bidwell ◽  
J. N. Waddell ◽  
T. M. Taxis ◽  
H. Yu ◽  
R. L. Tellam ◽  
...  
Keyword(s):  
Polar Overdominance ◽  
Callipyge Sheep

scholarly journals Identification of genes directly responding to DLK1 signaling in Callipyge sheep

BMC Genomics ◽  
2018 ◽  
Vol 19 (1) ◽  
Author(s):  
Hui Yu ◽  
Jolena N. Waddell ◽  
Shihuan Kuang ◽  
Ross L. Tellam ◽  
Noelle E. Cockett ◽  
...  
Keyword(s):  
Callipyge Sheep

scholarly journals Identification of a gene network contributing to hypertrophy in callipyge skeletal muscle

2007 ◽  
Vol 28 (3) ◽  
pp. 253-272 ◽  
Author(s):  
Tony Vuocolo ◽  
Keren Byrne ◽  
Jason White ◽  
Sean McWilliam ◽  
Antonio Reverter ◽  
...  
Keyword(s):  
Gene Expression ◽  
Skeletal Muscle ◽  
Muscle Hypertrophy ◽  
Fiber Type ◽  
Transcriptional Profiling ◽  
Developmental Time ◽  
Differentially Expressed ◽  
Core Network ◽  
Fast Twitch ◽  
Callipyge Sheep

The callipyge mutation in sheep results in postnatal skeletal muscle hypertrophy in the pelvic limbs and loins with little or no effect on anterior skeletal muscles. Associated with the phenotype are changes in the expression of a number of imprinted genes flanking the site of the mutation, which lies in an intergenic region at the telomeric end of ovine chromosome 18. The manner in which these local changes in gene expression are translated into muscle hypertrophy is not known. Microarray-based transcriptional profiling was used to identify differentially expressed genes in longissimus dorsi skeletal muscle samples taken at birth and 12 wk of age from callipyge and wild-type sheep. The phenotype was only expressed at the latter developmental time and associated with decreased type 1 fibers (slow oxidative) and a shift toward type IIx and IIb fibers (fast-twitch glycolytic). We have identified 131 genes in the samples taken at 12 wk of age that were differentially expressed as a function of genotype but not due to the fiber type changes. The gene expression changes occurring as a function of genotype in the samples taken at birth indicated that the transcriptional framework underpinning the phenotype was emerging prior to expression of the phenotype. Eight genes were differentially expressed as a function of genotype at both developmental times. A model is proposed describing a core network of genes and histone epigenetic modifications that is likely to underpin the fiber type changes and muscle hypertrophy characteristic of callipyge sheep.

scholarly journals Abnormal postnatal maintenance of elevated DLK1 transcript levels in callipyge sheep

2005 ◽  
Vol 16 (3) ◽  
pp. 171-183 ◽  
Author(s):  
Susan K. Murphy ◽  
Brad A. Freking ◽  
Timothy P.L. Smith ◽  
Kreg Leymaster ◽  
Catherine M. Nolan ◽  
...  
Keyword(s):  
Transcript Levels ◽  
Callipyge Sheep

Cis- and Trans-Effects Underlying Polar Overdominance at the Callipyge Locus

2013 ◽  
pp. 89-106 ◽  
Author(s):  
Michel Georges ◽  
Haruko Takeda ◽  
Huijun Cheng ◽  
Xu Xuewen ◽  
Tracy Hadfield-Shay ◽  
...  
Keyword(s):  
Polar Overdominance ◽  
Cis And Trans

P2026 Polar overdominance and maternal genome effects in placenta drive heterosis in utero

2016 ◽  
Vol 94 (suppl_4) ◽  
pp. 49-50
Author(s):  
C. A. S. Estrella ◽  
K. L. Kind ◽  
M. Ghanipoor-Samami ◽  
A. Javadmanesh ◽  
C. T. Roberts ◽  
...  
Keyword(s):  
In Utero ◽  
Maternal Genome ◽  
Polar Overdominance

scholarly journals Regulation of DLK1 by the maternally expressed miR-379/miR-544 cluster may underlie callipyge polar overdominance inheritance

2015 ◽  
Vol 112 (44) ◽  
pp. 13627-13632 ◽  
Author(s):  
Yun-Qian Gao ◽  
Xin Chen ◽  
Pei Wang ◽  
Lei Lu ◽  
Wei Zhao ◽  
...  
Keyword(s):  
Gastrocnemius Muscle ◽  
Tibialis Anterior Muscle ◽  
Gluteus Maximus ◽  
Iodothyronine Deiodinase ◽  
Longus Muscle ◽  
Elevated Expression ◽  
Gluteus Maximus Muscle ◽  
Polar Overdominance

Inheritance of the callipyge phenotype in sheep is an example of polar overdominance inheritance, an unusual mode of inheritance. To investigate the underlying molecular mechanism, we profiled the expression of the genes located in the Delta-like 1 homolog (Dlk1)–type III iodothyronine deiodinase (Dio3) imprinting region in mice. We found that the transcripts of the microRNA (miR) 379/miR-544 cluster were highly expressed in neonatal muscle and paralleled the expression of the Dlk1. We then determined the in vivo role of the miR-379/miR-544 cluster by establishing a mouse line in which the cluster was ablated. The maternal heterozygotes of young mutant mice displayed a hypertrophic tibialis anterior muscle, extensor digitorum longus muscle, gastrocnemius muscle, and gluteus maximus muscle and elevated expression of the DLK1 protein. Reduced expression of DLK1 was mediated by miR-329, a member of this cluster. Our results suggest that maternal expression of the imprinted miR-379/miR-544 cluster regulates paternal expression of the Dlk1 gene in mice. We therefore propose a miR-based molecular working model for polar overdominance inheritance.

The calpain system in three muscles of normal and callipyge sheep.

2001 ◽  
Vol 79 (2) ◽  
pp. 398 ◽  
Author(s):  
E F Delgado ◽  
G H Geesink ◽  
J A Marchello ◽  
D E Goll ◽  
M Koohmaraie
Keyword(s):  
Callipyge Sheep ◽  
Calpain System

scholarly journals Toward Molecular Understanding of Polar Overdominance at the Ovine Callipyge Locus

2004 ◽  
Vol 69 (0) ◽  
pp. 477-484 ◽  
Author(s):  
M. GEORGES ◽  
C. CHARLIER ◽  
M. SMIT ◽  
E. DAVIS ◽  
T. SHAY ◽  
...  
Keyword(s):  
Polar Overdominance

scholarly journals POLAR OVERDOMINANCE AT THE CALLIPYGE LOCUS IN SHEEP

1998 ◽  
Vol 26 (Supplement) ◽  
pp. 1-9 ◽  
Author(s):  
N.E. Cockett ◽  
S.P. Jackson ◽  
G.D. Snowder ◽  
T.L. Shay ◽  
S. Berghmans ◽  
...  
Keyword(s):  
Polar Overdominance
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