A high-resolution radiation hybrid map of the river buffalo major histocompatibility complex and comparison with BoLA

2012 ◽  
Vol 44 (4) ◽  
pp. 369-376 ◽  
Author(s):  
N. B. Stafuzza ◽  
A. J. Greco ◽  
J. R. Grant ◽  
C. A. Abbey ◽  
C. A. Gill ◽  
...  
Keyword(s):  
Major Histocompatibility Complex ◽  
High Resolution ◽  
Radiation Hybrid ◽  
River Buffalo ◽  
Major Histocompatibility ◽  
Histocompatibility Complex ◽  
Radiation Hybrid Map

scholarly journals New Functions of the Major Histocompatibility Complex Class II-Specific Transcription Factor RFXANK Revealed by a High-Resolution Mutagenesis Study

2005 ◽  
Vol 25 (19) ◽  
pp. 8607-8618 ◽  
Author(s):  
Michal Krawczyk ◽  
Krzysztof Masternak ◽  
Madeleine Zufferey ◽  
Emmanuèle Barras ◽  
Walter Reith
Keyword(s):  
Major Histocompatibility Complex ◽  
High Resolution ◽  
Major Histocompatibility Complex Class ◽  
Class Ii ◽  
Ankyrin Repeat ◽  
Complex Class ◽  
Major Histocompatibility ◽  
Mhc Ii ◽  
Histocompatibility Complex ◽  
Rfx Complex

ABSTRACT The transcription factors RFX and CIITA are major players in regulation of the expression of all classical and nonclassical major histocompatibility complex class II (MHC-II) genes. RFX nucleates the formation of a multiprotein complex, called the MHC-II enhanceosome, on MHC-II promoters. Assembly of this enhanceosome is an obligatory step for recruitment of the coactivator CIITA and thus for activation of MHC-II gene transcription. We have analyzed the function of the ankyrin repeat-containing protein RFXANK, which forms the heterotrimeric RFX complex together with RFX5 and RFXAP. We discovered that ANKRA2, the closest paralogue of RFXANK, can substitute for RFXANK in the activation of MHC-II genes and that this ability is mediated by its ankyrin repeat domain (ARD). This finding provided the basis for a high-resolution structure-function analysis of the ARD of RFXANK, which allowed us to map the RFX5 interaction domain and residues critical for assembly of the RFX complex. We also found that mutations in the fourth ankyrin repeat of RFXANK abolish assembly of the enhanceosome on MHC-II promoters in vivo but not in vitro, suggesting a new role of RFXANK in facilitating promoter occupation in the context of chromatin.

scholarly journals Adaptive selection signatures in river buffalo with emphasis on immune and major histocompatibility complex genes

Genomics ◽  
2021 ◽  
Vol 113 (6) ◽  
pp. 3599-3609
Author(s):  
Yan Ren ◽  
Callum MacPhillamy ◽  
Thu-Hien To ◽  
Timothy P.L. Smith ◽  
John L. Williams ◽  
...  
Keyword(s):  
Major Histocompatibility Complex ◽  
River Buffalo ◽  
Major Histocompatibility ◽  
Selection Signatures ◽  
Adaptive Selection ◽  
Histocompatibility Complex

scholarly journals High Resolution Structures of Highly Bulged Viral Epitopes Bound to Major Histocompatibility Complex Class I

2005 ◽  
Vol 280 (25) ◽  
pp. 23900-23909 ◽  
Author(s):  
Fleur E. Tynan ◽  
Natalie A. Borg ◽  
John J. Miles ◽  
Travis Beddoe ◽  
Diah El-Hassen ◽  
...  
Keyword(s):  
Major Histocompatibility Complex ◽  
High Resolution ◽  
Major Histocompatibility Complex Class ◽  
Class I ◽  
Complex Class ◽  
Major Histocompatibility ◽  
Histocompatibility Complex
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