Effects of a prior authorization policy for extended-release/long-acting opioids on utilization and outcomes in a state Medicaid program

Addiction ◽  
2018 ◽  
Vol 113 (9) ◽  
pp. 1651-1660 ◽  
Author(s):  
Shellie L. Keast ◽  
Hyunjee Kim ◽  
Richard A. Deyo ◽  
Luke Middleton ◽  
K. John McConnell ◽  
...  
Keyword(s):  
Extended Release ◽  
Prior Authorization ◽  
Medicaid Program ◽  
Authorization Policy ◽  
Long Acting

Comparative study of extended release albuterol sulfate and long-acting inhaled salmeterol xinafoate in the treatment of nocturnal asthma

1999 ◽  
Vol 83 (2) ◽  
pp. 121-126 ◽  
Author(s):  
Richard J. Martin ◽  
Monica Kraft ◽  
Wilfred N. Beaucher ◽  
Frederic Kiechel ◽  
James L. Sublett ◽  
...  
Keyword(s):  
Comparative Study ◽  
Extended Release ◽  
Nocturnal Asthma ◽  
Salmeterol Xinafoate ◽  
Albuterol Sulfate ◽  
Long Acting

scholarly journals Impact of a National Private Health Insurer’s Prior Authorization Policy on Utilization of Vaginal Hysterectomy

2019 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Carolyn W. Swenson ◽  
Neil S. Kamdar ◽  
Kristian Seiler ◽  
Daniel M. Morgan
Keyword(s):  
Vaginal Hysterectomy ◽  
Prior Authorization ◽  
Authorization Policy

Opioid Pharmacotherapies for Chronic Pain (DRAFT)

2018 ◽  
Author(s):  
Thien C. Pham ◽  
Courtney Kominek ◽  
Abigail Brooks ◽  
Jeffrey Fudin
Keyword(s):  
Chronic Pain ◽  
Extended Release ◽  
Opioid Analgesics ◽  
Chronic Pain Management ◽  
Opioid Use ◽  
Daily Dose ◽  
Long Acting ◽  
Conversion Tool ◽  
Morphine Equivalent

Chronic pain management employing opioids is divided into subtopics, including: risk–benefit balance; a review of the mode of action of opioid analgesics (Chap. 8); the suitability of synthetic opioids for neuropathic pain; endocrinopathy proceeding from opioid use; the use of the morphine-equivalent daily dose as a conversion tool for managing multiple opioids; the place of extended-release and long-acting opioids; current technology in abuse deterrence; and an overview of the challenges entailed in prescribing. This last section details the complex components of a decision to prescribe opioids for chronic pain. A table is provided of the classification of common opioid analgesics and their duration of activity. A text box gives the table of contents of Appendix B, supportive tables and figures therein for this chapter; there is also a text box listing additional resources.

The Pharmacology of Opioids (DRAFT)

2018 ◽  
Author(s):  
Christopher Cavacuiti
Keyword(s):  
Adverse Effects ◽  
Opioid Receptor ◽  
Extended Release ◽  
Receptor Subtypes ◽  
Synthetic Method ◽  
Physiological Effects ◽  
Opioid Use ◽  
Receptor Affinity ◽  
Opioid Receptor Subtypes ◽  
Long Acting

This chapter focuses on the attributes of and component medications within the class of opioids, emphasizing kinetics, dynamics, and therapeutic and adverse effects. To help patients make informed decisions about opioid use, the clinicians prescribing these medications must be able to explain when opioids are likely to help and when they are likely to do harm. Subclasses of opioids include phenanthrenes, benzomorphans, phenylpiperidines, and diphenylheptanes; examples are given of each, with respective utilities and limitations. A discussion then follows of pharmacodynamics, pharmacokinetics, opioid receptor affinity, metabolism, and drug interactions. Tables and figures amplifying the text include: opioid class by synthetic method (Table 8.1); common physiological effects by opioid receptor subtypes (Table 8.2); opioid activity (Table 8.3); and a listing of figures and tables located in Appendix B (opioid receptor affinity, respiratory depression with opioids, adverse effects, metabolism, pharmacogenetics, extended release/long-acting opioids, abuse deterrent formulations). A text box provides supplemental resources.

scholarly journals Gaps in the Use of Long-Acting Opioids Within Intervals of Consecutive Days Among Cancer Outpatients Using Electronic Pill Caps

Pain Medicine ◽  
2020 ◽  
Author(s):  
Salimah H Meghani ◽  
Amelia L Persico ◽  
Jeffrey Fudin ◽  
George J Knafl
Keyword(s):  
Cancer Patients ◽  
Extended Release ◽  
Electronic Monitoring ◽  
Secondary Analysis ◽  
Study Participant ◽  
Current Analysis ◽  
Opioid Use ◽  
Event Monitoring ◽  
Atlantic Region ◽  
Long Acting

Abstract Objective This study describes individual cancer patients’ nonuse of extended-release or long-acting (ER/LA) opioids, including periods of gap between opioid doses taken. Design Secondary analysis of a three-month observational study of prescribed ER/LA opioids monitored using electronic pill caps. Setting Two outpatient oncology clinics of a large health system in the Mid-Atlantic region. Participants Inclusion was based on self-identified African Americans and whites, at least 18 years old, diagnosed with solid tumors or multiple myeloma. For the current analysis, the additional inclusion criterion was prescription of an oral ER/LA opioid for cancer pain to be taken around the clock. Methods The electronic monitoring period for each study participant was partitioned into intervals of days between days with one or more openings (using medication event monitoring systems) representing rates of ER/LA opioid nonuse over consecutive days and over time. Results Of the sample (N = 109), two-thirds of the cancer patients had some nonuse of prescribed ER/LA opioids, with one in four having nonuse during 31.5–87.5% of their electronic-monitoring periods. Nonuse over periods of five or more, six or more, and seven or more consecutive days occurred for 37.6%, 34.9%, and 30.3% of the participants, respectively. Conclusions About one in three ambulatory cancer patients in this study had substantial gaps between days of ER/LA opioid use, potentially resulting in risk of overdose depending upon the prescribed ER/LA opioid type, dose, and length of the time the opioid was stopped and resumed at the previous dose. This phenomenon has received little to no attention in the opioid safety discourse.

scholarly journals Subcutaneous Extended-Release Buprenorphine Use in Pregnancy

2020 ◽  
Vol 2020 ◽  
pp. 1-3
Author(s):  
Craig V. Towers ◽  
Heather Deisher
Keyword(s):  
Extended Release ◽  
Opioid Use Disorder ◽  
Adverse Outcomes ◽  
Extensive Literature ◽  
Opioid Use ◽  
Sublingual Buprenorphine ◽  
Medication Assisted Treatment ◽  
Urine Drug ◽  
Long Acting ◽  
In Pregnancy

Background. Opioid use disorder (OUD) in pregnancy is managed by medication-assisted treatment. Sublingual buprenorphine is one option, but subcutaneous extended-release buprenorphine (Sublocade®) is an alternate form administered in monthly injections. Through an extensive literature search, we did not find any prior publication on the use of Sublocade in pregnancy. Case. Two patients with OUD switched from sublingual buprenorphine to Sublocade. One patient received a total of eight injections and then discovered she was pregnant. Based on ultrasound dating, the last 5 administrations occurred during her pregnancy. The second patient received 6 injections with the last occurring at the time of her last menstrual period. Both declined further injections, as well as oral buprenorphine. Serial urine drug screens remained positive for buprenorphine through delivery in both cases. Neither the mothers nor the neonates experienced withdrawal symptoms or adverse outcomes. No birth anomalies were found. Discussion. Though further research is needed regarding the use of Sublocade in pregnancy, it is likely that other pregnancies will occur during this treatment modality. If this long-acting form of buprenorphine medication is found to be safe, it might play a role in managing some pregnant patients with OUD.

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