Sex differences in genetic and environmental contributions to alcohol consumption from early adolescence to young adulthood

Addiction ◽  
2016 ◽  
Vol 111 (7) ◽  
pp. 1188-1195 ◽  
Author(s):  
Karoline B. Seglem ◽  
Trine Waaktaar ◽  
Helga Ask ◽  
Svenn Torgersen
Keyword(s):  
Sex Differences ◽  
Alcohol Consumption ◽  
Young Adulthood ◽  
Early Adolescence

scholarly journals Sex differences in baseline risk factors for the incidence of asthma between early adolescence and young adulthood

2021 ◽  
Vol 33 (1) ◽  
Author(s):  
P Kalm-Stephens ◽  
L Nordvall ◽  
C Janson ◽  
A Malinovschi ◽  
K Alving
Keyword(s):  
Risk Factors ◽  
Sex Differences ◽  
Young Adulthood ◽  
Early Adolescence ◽  
Interaction Analysis ◽  
Early Adulthood ◽  
Baseline Risk ◽  
Allergic Symptoms ◽  
Incident Asthma ◽  
Adolescence And Young Adulthood

Background: Several studies have shown sex differences in the prevalence of asthma and a relationship to age. The aim of the present study was to prospectively investigate the development of asthma, wheeze, rhinitis and allergic symptoms, between adolescence and adulthood. Furthermore, to determine if sex modifies the associations between baseline risk factors and incidence of asthma in early adulthood. Methods: In the study Screening Project Asthma in Schools(SPAIS), adolescents aged 12–15 years answered a standardised respiratory questionnaire (ISAAC) and underwent measurements of fractional exhaled nitric oxide (FeNO) and lung function (FEV1) at baseline. Two follow-ups with similar questionnaires were performed after four and 16 years, with 491 subjects participating in all three examinations. Results: The prevalence of asthma and wheeze were unchanged after four years, but had increased after 16 years. However, the increase was significant only for females. A more continuous increasein rhinitis and allergic symptoms showed no difference between the sexes. Sex interaction analysis showed that higher FeNO (p = 0.01) and family asthma (p = 0.02) increased the risk of incident asthma for males but not for females. Conclusions: An increased prevalence of respiratory symptoms was seen primarily between late adolescence and young adulthood, and was significant for females but not males. Allergic risk factors in early adolescence for incident asthma in early adulthood were confirmed in males but not in females. Awareness of these sex differences in the development of symptoms, and the associated risk factors, are important in clinical practice.

scholarly journals Predictors of disordered eating in adolescence and young adulthood

2013 ◽  
Vol 38 (2) ◽  
pp. 128-138 ◽  
Author(s):  
Dawit Shawel Abebe ◽  
Leila Torgersen ◽  
Lars Lien ◽  
Gertrud S. Hafstad ◽  
Tilmann von Soest
Keyword(s):  
Risk Factors ◽  
Disordered Eating ◽  
Young Adulthood ◽  
Early Adolescence ◽  
Developmental Psychopathology ◽  
Population Based ◽  
Specific Risk ◽  
Random Intercept ◽  
Developmental Phases ◽  
Gender Specific

We investigated longitudinal predictors for disordered eating from early adolescence to young adulthood (12–34 years) across gender and different developmental phases among Norwegian young people. Survey data from a population-based sample were collected at four time points (T) over a 13-year time span. A population-based sample of 5,679 females and males at T1 and T2, 2,745 at T3 and 2,718 at T4 were included in analyses, and linear regression and random intercept models were applied. In adolescence, initial disordered eating and parental overprotectiveness were more strongly related to disordered eating among females, whereas loneliness was a stronger predictor for adolescent males. Initial disordered eating during early adolescence predicted later disordered eating more strongly in late- than mid-adolescence. In young adulthood, no significant gender-specific risk factors were found. The findings provide support for both shared and specific risk factors for the developmental psychopathology of disordered eating.

scholarly journals Sex differences and developmental stability in genetic and environmental influences on psychoactive substance consumption from early adolescence to young adulthood

2011 ◽  
Vol 41 (9) ◽  
pp. 1907-1916 ◽  
Author(s):  
J. H. Baker ◽  
H. H. Maes ◽  
H. Larsson ◽  
P. Lichtenstein ◽  
K. S. Kendler
Keyword(s):  
Substance Use ◽  
Young Adulthood ◽  
Early Adolescence ◽  
Illicit Drug ◽  
Common Factor ◽  
Environmental Influences ◽  
Genetic Effects ◽  
Shared Environment ◽  
Males And Females ◽  
Substance Consumption

BackgroundGenetic and environmental factors are important in the etiology of substance use. However, little is known about the stability of these factors across development. We aimed to answer three crucial questions about this etiology that have never been addressed in a single study: (1) Is there a general vulnerability to substance consumption from early adolescence to young adulthood? (2) If so, do the genetic and environmental influences on this vulnerability change across development? (3) Do these developmental processes differ in males and females?MethodSubjects included 1480 twin pairs from the Swedish Twin Study of Child and Adolescent Development who have been followed since 1994. Prospective, self-reported regular smoking, alcohol intoxication and illicit drug use were assessed at ages 13–14, 16–17 and 19–20 years. Structural modeling was performed with the program Mx.ResultsAn underlying common factor accounted for the association between smoking, alcohol and illicit drug consumption for the three age groups. Common genetic and shared environmental effects showed substantial continuity. In general, as participants aged, the influence of the shared environment decreased, and genetic effects became more substance specific in their effect.ConclusionsThe current report answers three important questions in the etiology of substance use. The genetic and environmental risk for substance consumption is partly mediated through a common factor and is partly substance specific. Developmentally, evidence was strongest for stability of common genetic effects, with less evidence for genetic innovation. These processes seem to be the same in males and females.

scholarly journals Sex differences in cognitive performance and alcohol consumption in High Alcohol-Drinking (HAD-1) rats

2020 ◽  
Vol 381 ◽  
pp. 112456
Author(s):  
N. Mittal ◽  
S.M. Fleming ◽  
A. Martinez ◽  
N. Thakore ◽  
R.L. Bell ◽  
...  
Keyword(s):  
Sex Differences ◽  
Alcohol Consumption ◽  
Cognitive Performance ◽  
Alcohol Drinking ◽  
High Alcohol

scholarly journals Prevalence and stability of insomnia from preschool to early adolescence: a prospective cohort study in Norway

2020 ◽  
Vol 4 (1) ◽  
pp. e000660
Author(s):  
Jonas Falch-Madsen ◽  
Lars Wichstrøm ◽  
Ståle Pallesen ◽  
Silje Steinsbekk
Keyword(s):  
Sex Differences ◽  
Cohort Study ◽  
Early Adolescence ◽  
Community Sample ◽  
Statistical Manual ◽  
Diagnostic And Statistical Manual ◽  
Dsm 5 ◽  
Parents And Children ◽  
Dsm Iv ◽  
Time Point

BackgroundThere is limited knowledge about the prevalence and stability of insomnia defined by the Diagnostic and Statistical Manual of Mental Disorders (DSM). We therefore provide such estimates from preschool to early adolescence and explore potential sex differences.MethodsWe followed a representative community sample (n=1037) biennially from 4 to 14 years of age (2007–2017). Insomnia diagnoses and symptoms were captured by a semistructured clinical interview of parents and children (from age 8 years).ResultsAt ages 4 and 6 years approximately 2.5% of children met the criteria for insomnia, whereas at ages 8, 10, 12 and 14 years the prevalence ranged from 7.5% to 12.3%. During the 10-year period examined nearly 1 in 5 children had insomnia at least once (18.7%). Sex differences were apparent with DSM-IV, but not DSM-5, criteria: boys (8.1%) had more insomnia than girls (4.5%) did at ages 4–10 years, whereas girls (11.4%) had more insomnia than boys (7.1%) did at ages 12 and 14 years. Insomnia proved stable, with 22.9%–40.1% of children retaining their diagnosis 2 years later. Having current insomnia produced medium to large ORs of between 5.1 (95% CI 2.6 to 9.8) and 15.3 (95% CI 4.4 to 52.9) for subsequent insomnia 2 years later compared with not having preceding insomnia.ConclusionsInsomnia was less prevalent than previous research indicates, with nearly 1 in 5 participants having insomnia at least once between the ages of 4 and 14 years. Female preponderance emerged in early adolescence. Having insomnia at one time point was a considerable risk for subsequent insomnia, indicating that insomnia is persistent and warrants clinical attention.

Latent trajectories of alcohol use from early adolescence to young adulthood: Interaction effects between 5-HTTLPR and parenting quality and gender differences

2018 ◽  
Vol 31 (02) ◽  
pp. 457-469 ◽  
Author(s):  
Jinni Su ◽  
Andrew J. Supple ◽  
Esther M. Leerkes ◽  
Sally I-Chun Kuo
Keyword(s):  
Alcohol Use ◽  
Young Adulthood ◽  
Early Adolescence ◽  
Late Onset ◽  
Growth Mixture Modeling ◽  
Heavy Alcohol ◽  
Parenting Quality ◽  
Heavy Alcohol Use ◽  
And Gender ◽  
Alcohol Use Trajectories

AbstractUsing a large and nationally representative sample, we examined how adolescents’ 5-HTTLPR genotype and perceived parenting quality independently and interactively associated with trajectories of alcohol use from early adolescence to young adulthood and whether/how gender may moderate these associations. The sample for this study included 13,749 adolescents (53.3% female; 56.3% non-Hispanic White, 21.5% Black, 16.0% Hispanic, and 6.1% Asian) followed prospectively from adolescence to young adulthood. Using growth mixture modeling, we identified four distinct trajectories of alcohol use (i.e., persistent heavy alcohol use, developmentally limited alcohol use, late-onset heavy alcohol use, and non/light alcohol use). Results indicated that the short allele of 5-HTTLPR was associated with higher risk of membership in the persistent and the late-onset heavy alcohol use trajectories. Parenting quality was associated with lower likelihoods of following the persistent heavy and the developmentally limited alcohol use trajectories but was not associated with risk of membership for the late-onset heavy drinking trajectory. 5-HTTLPR interacted with parenting quality to predict membership in the persistent heavy alcohol use trajectory for males but not for females. Findings highlighted the importance of considering the heterogeneity in trajectories of alcohol use across development and gender in the study of Gene Environment interactions in alcohol use.

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