scholarly journals Sulphated dehydroepiandrosterone serum levels are reduced in women with alcohol use disorder and correlate negatively with craving: A sex‐separated cross‐sectional and longitudinal study

2022 ◽  
Vol 27 (2) ◽  
Author(s):  
Christian Weinland ◽  
Christiane Mühle ◽  
Claudia Zimmermann ◽  
Johannes Kornhuber ◽  
Bernd Lenz
Keyword(s):  
Longitudinal Study ◽  
Alcohol Use ◽  
Alcohol Use Disorder ◽  
Serum Levels ◽  
Cross Sectional

scholarly journals Assessment of alcohol use disorder and its associated factors among alcohol users of medical and surgical outpatients attending a specialized hospital in Gondar, Ethiopia: a cross-sectional study

2021 ◽  
Vol 15 (1) ◽  
Author(s):  
Demeke Demilew ◽  
Berhanu Boru ◽  
Getachew Tesfaw ◽  
Habtamu Kerebih ◽  
Endalamaw Salelew
Keyword(s):  
Alcohol Use ◽  
Associated Factors ◽  
Alcohol Use Disorder ◽  
Alcohol Use Disorders ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Multivariate Logistic Regression ◽  
Cross Sectional ◽  
History Of ◽  
Male Sex

Abstract Background Alcohol use disorder increase the risk of physical harm, mental or social consequences for patients and others in the community. Studies on alcohol use disorder and associated factors among medical and surgical outpatients in Ethiopia are limited. Therefore, this study is meant to provide essential data on alcohol use disorder and associated factors among alcohol user medical and surgical outpatients to intervene in the future. Methods An institution-based cross-sectional study was conducted by using the systematic random sampling technique. Alcohol use disorders were assessed using the World Health Organization’s 10-item Alcohol Use Disorder Identification Test (AUDIT) questionnaire. Bivariate and multivariate logistic regression analyses were performed, a P-value less than 0.05 were considered statistically significant in the multivariate analysis and the strength of association was measured at a 95% confidence interval. Results The prevalence of alcohol use disorder was 34.5% with a 95% CI (29.20, 39.80) among study participants. In the multivariate logistic regression analysis, male sex (AOR = 3.33, 95%CI: 1.40, 7.93), history of mental illness (AOR = 2.68, 95%CI: 1.12, 6.38), drinking for relaxation (AOR = 1.88, 95%CI: 1.02, 3.48) and history of lifetime tobacco use (AOR = 5.64, 95%CI: 1.95, 16.29) were factors significantly associated with alcohol use disorder. Conclusion The prevalence of alcohol use disorders among medical and surgical outpatients was found to be high. Male sex, history of mental illness, alcohol use for relaxation and lifetime cigarette smoking need more attention during the assessment of patients in the medical and surgical outpatient departments.

scholarly journals Dynamic Changes of the Fungal Microbiome in Alcohol Use Disorder

2021 ◽  
Vol 12 ◽  
Author(s):  
Phillipp Hartmann ◽  
Sonja Lang ◽  
Suling Zeng ◽  
Yi Duan ◽  
Xinlian Zhang ◽  
...  
Keyword(s):  
Liver Disease ◽  
Alcohol Use ◽  
Alcohol Use Disorder ◽  
Serum Levels ◽  
Amplicon Sequencing ◽  
Dynamic Changes ◽  
Alcohol Abstinence ◽  
Liver Health ◽  
Fungal Microbiome ◽  
Progressive Liver Disease

BackgroundAlcohol-associated liver disease (ALD) is an important cause of morbidity and mortality worldwide. The intestinal microbiota is involved in the development and progression of ALD; however, little is known about commensal fungi therein.MethodsWe studied the dynamic changes of the intestinal fungal microbiome, or mycobiome, in 66 patients with alcohol use disorder (AUD) and after 2 weeks of alcohol abstinence using internal transcribed spacer 2 (ITS2) amplicon sequencing of fecal samples.ResultsPatients with AUD had significantly increased abundance of the genera Candida, Debaryomyces, Pichia, Kluyveromyces, and Issatchenkia, and of the species Candida albicans and Candida zeylanoides compared with control subjects. Significantly improved liver health markers caspase-cleaved and intact cytokeratin 18 (CK18-M65) levels and controlled attenuation parameter (CAP) in AUD patients after 2 weeks of alcohol abstinence were associated with significantly lower abundance of the genera Candida, Malassezia, Pichia, Kluyveromyces, Issatchenkia, and the species C. albicans and C. zeylanoides. This was mirrored by significantly higher specific anti-C. albicans immunoglobulin G (IgG) and M (IgM) serum levels in AUD patients in relation to control participants, and significantly decreased anti-C. albicans IgG levels in AUD subjects after 2 weeks of abstinence. The intestinal abundance of the genus Malassezia was significantly higher in AUD subjects with progressive liver disease compared with non-progressive liver disease.ConclusionIn conclusion, improved liver health in AUD patients after alcohol abstinence was associated with lower intestinal abundances of Candida and Malassezia, and lower serum anti-C. albicans IgG levels. Intestinal fungi might serve as a therapeutic target to improve the outcome of patients in ALD.

scholarly journals False Identification Use Among College Students Increases the Risk for Alcohol Use Disorder: Results of a Longitudinal Study

2013 ◽  
Vol 38 (3) ◽  
pp. 834-843 ◽  
Author(s):  
Amelia M. Arria ◽  
Kimberly M. Caldeira ◽  
Kathryn B. Vincent ◽  
Brittany A. Bugbee ◽  
Kevin E. O'Grady
Keyword(s):  
College Students ◽  
Longitudinal Study ◽  
Alcohol Use ◽  
Alcohol Use Disorder ◽  
False Identification

scholarly journals Cognitive function and alcohol use disorder: Path analysis for a cross-sectional study in Taiwan

2021 ◽  
Vol 35 (3) ◽  
pp. 124
Author(s):  
FrankHuang-Chih Chou ◽  
Kuan-Ying Hsieh ◽  
Chun-Hua Cheng ◽  
Li-Ling Huang ◽  
Wei-Tsung Kao ◽  
...  
Keyword(s):  
Cognitive Function ◽  
Alcohol Use ◽  
Path Analysis ◽  
Alcohol Use Disorder ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional

scholarly journals Association between Nightlife Goers’ Likelihood of an Alcohol Use Disorder and Their Preferred Bar’s Closing Time: A Cross-Sectional Observational Study in Perth, Australia

2021 ◽  
Vol 18 (24) ◽  
pp. 13040
Author(s):  
William Gilmore ◽  
Martyn Symons ◽  
Wenbin Liang ◽  
Kathryn Graham ◽  
Kypros Kypri ◽  
...  
Keyword(s):  
Alcohol Use ◽  
Observational Study ◽  
Alcohol Use Disorder ◽  
Positive Association ◽  
Hazardous Drinking ◽  
Closing Time ◽  
Cross Sectional ◽  
Logistic Regression Models ◽  
Design And Methods ◽  
New Evidence

Introduction and aims: Associations between longer-term alcohol-related conditions and licensed outlet trading hours are not well understood. We investigated the association between nightlife-goers’ likelihood of an alcohol use disorder (AUD) and their preference for bars with special permits to remain open ‘late’ (i.e., spent more time there compared to any other venue) until 2 a.m. or 3 a.m. (Friday; Saturday) or midnight (Sunday) compared to bars with ‘standard’ closing times of midnight (Friday; Saturday) or 10 p.m. (Sunday). Design and methods: A cross-sectional observational study was conducted in four major nightlife areas of Perth, Australia, in 2015–2016. We conducted weekend street intercept surveys outside bars between 8 p.m. and 3 a.m. and screened participants who reported alcohol use prior to the survey and spent more time in a bar than any other venue type (n = 667) regarding their past year drinking pattern using AUDIT-C (n = 459). We used gender-specific logistic regression models to estimate associations between AUDIT-C categories (1–4, low risk; 5–7, hazardous; 8–12, active AUD) and preference for bars with different closing times (late vs. standard). Results: A large proportion of participants were hazardous drinkers or had active AUD (83% males; 65% females), and over half preferred a late to a standard closing bar. We found evidence of a positive association between preference for late closing bars and hazardous drinking females (OR = 3.48; 95% CI 1.47–8.23; p = 0.01), but not for females with active AUD, male hazardous drinkers, nor males with active AUD. Discussion and conclusions: Our study adds new evidence on associations between likelihood of AUD among nightlife-goers and trading hours. With increasing international relaxation of trading hours, evidence that late closing bars may be preferred by hazardous drinking females will be of concern to policymakers wanting to curb alcohol-related harms in the community.

scholarly journals Prevalence and correlates of non-daily and daily cannabis use among persons 15 years and older in South Africa: Results of a national survey in 2017

2020 ◽  
Author(s):  
Shandir Ramlagan ◽  
Karl Peltzer ◽  
Supa Pengpid
Keyword(s):  
Logistic Regression ◽  
Alcohol Use ◽  
Drug Use ◽  
Alcohol Use Disorder ◽  
Multinomial Logistic Regression ◽  
Health Indicators ◽  
Cannabis Use ◽  
Cross Sectional ◽  
Negatively Associated ◽  
Male Sex

Abstract BackgroundThe study aimed to assess the prevalence and correlates of non-daily and daily cannabis use among persons 15 years and older in South Africa.MethodIn a national cross-sectional 2017 survey, 39,207 persons 15 years and older (Median = 34 years) responded to a questionnaire on substance use and health variables. Multinominal logistic regression was used to assess the determinants of nondaily and daily cannabis use and logistic regression for the determinants of daily cannabis use among active cannabis users.ResultsResults indicate that 5.0% of the participants engaged in non-daily and 2.8% in daily cannabis use in the past 3 months. In adjusted multinomial logistic regression analysis, male sex, having Grade 8–11 education, Coloureds, alcohol use disorder, living with husband or wife, not living with a partner, and other drug use were positively and students were negatively associated with daily cannabis use. Male sex, younger age, living alone or single, living with a partner, alcohol use disorder, and other drug use were positively and multimorbidity was negatively associated with nondaily cannabis use. Compared to nondaily cannabis users, male sex had higher odds and students and other drug use had lower odds of daily cannabis use.ConclusionAbout one in ten participants engaged past 3-month cannabis use, and several sociodemographic and health indicators were identified associated with non-daily and daily cannabis use.

scholarly journals Alcohol use disorder and its determinant factors among patients with schizophrenia attending treatment at mental specialized hospital, Addis Ababa, Ethiopia: A cross-sectional study

2021 ◽  
Vol 9 ◽  
pp. 205031212110487
Author(s):  
Habtamu Tadesse ◽  
Yohannes Mirkana ◽  
Tadesse Misgana
Keyword(s):  
Alcohol Use ◽  
Alcohol Use Disorder ◽  
Addis Ababa ◽  
Previous History ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Duration Of Illness ◽  
Specialized Hospital ◽  
Audit Score ◽  
History Of

Background: Alcohol use disorder is one of the primary causes of avoidable death, illness, and injury in many societies throughout the world. Although alcohol use disorder can influence the natural history of a disease, disease recurrence, quality of life, and treatment adherence in psychiatric patients, the data on its magnitude is scarce. Objectives: This study was aimed to determine the magnitude of alcohol use disorder and its determinants among patients with schizophrenia attending a mental specialized hospital in Addis Ababa, Ethiopia. Methods: An institutional-based cross-sectional study was conducted from May 15 to June 15, 2018. An alcohol use disorder identification test was employed among a sample of 414 randomly selected patients with schizophrenia. Alcohol use disorder was categorized as hazardous drinking (Alcohol Use Disorders Identification Test (AUDIT) score of 8–15), harmful drinking (AUDIT score of 16–19), and alcohol dependence (AUDIT score of 20 or above). The data were entered into Epi-Data 3.1 and exported to SPSS 20 for analysis. Logistic regression was fitted to identify factors associated with alcohol use disorder. Results: The prevalence of alcohol use disorder was 38.4% (95% confidence interval (CI) 33.7, 42.9). Of this, 22.4% of the patients had hazardous drinking, 8.4% harmful drinking, and 7.6% alcohol dependence. Factors associated with alcohol use disorder were male sex (adjusted odds ratio (AOR) = 5.8, 95% CI 2.55, 13.19), being single (AOR = 3.0, 95% CI 1.63, 5.51), divorced (AOR = 4.3, 95% CI 1.95, 9.47) and widowed (AOR = 3.5, 95% CI 1.39, 8.81), having family history of alcoholism (AOR = 3.8, 95% CI 1.98, 7.19), longer duration of illness (AOR = 3.9, 95% CI 1.83, 8.36), previous history of psychiatric diagnosis (AOR = 2.2, 95% CI 1.1, 4.34), and concomitant use of non-alcoholic substances (AOR = 3.7, 95% CI 2.06, 6.74). Conclusions: Almost four in ten patients with schizophrenia had alcohol use disorder. Male sex, single, divorced, and widowed, family history of alcohol use, long duration of illness, previous history of psychiatric diagnosis, and concomitant use of non-alcoholic substances were significantly associated with alcohol use disorder. Continuous counseling of at risk populations about alcohol consumption should be strengthened.

scholarly journals Association between parental separation and addictions in adolescents: results of a national Lebanese study

2020 ◽  
Author(s):  
Nour Jabbour ◽  
Vanessa Abi Rached ◽  
Chadia Haddad ◽  
Pascale Salameh ◽  
Hala Sacre ◽  
...  
Keyword(s):  
Alcohol Use ◽  
Random Sample ◽  
Internet Addiction ◽  
Representative Sample ◽  
Alcohol Use Disorder ◽  
Higher Alcohol ◽  
Cross Sectional ◽  
The Mean ◽  
Cigarette Dependence

Abstract Objectives: to investigate the association between the divorce of parents and smoking, alcohol, and internet addiction among a representative sample of Lebanese adolescents.Methods: This study was a cross-sectional, conducted between January and May 2019 using a proportionate random sample of schools from all Lebanese Mohafazat. Out of 2000 questionnaires distributed; 1810 (90.5%) were completed and collected back.Results: The mean age was 15.42 ± 1.14 years, with 53.3% females and 74.1% smokers. In addition, 11.9% [95% CI 0.104-0.134] of the adolescents had separated/divorced parents. Divorce in parents was significantly associated with higher alcohol use disorder (Beta=8.035), higher cigarette dependence (Beta=2.767) and a higher waterpipe dependence (Beta=5.263) in adolescents. However, divorce in parents was not associated with internet addiction in adolescents.Conclusion: Parental divorce was correlated to higher alcohol and smoking, but not internet addiction among adolescents. Children whose parents are divorced should be subject to continuous follow-up by their parents and by a psychiatrist/psychologist in order not to develop any addiction that could potentially harm them.

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