Regulation of miR‐128 in the nucleus accumbens affects methamphetamine‐induced behavioral sensitization by modulating proteins involved in neuroplasticity

2020 ◽  
Vol 26 (1) ◽  
Author(s):  
Jiaqi Li ◽  
Li Zhu ◽  
Hang Su ◽  
Dan Liu ◽  
Zhilan Yan ◽  
...  
Keyword(s):  
Nucleus Accumbens ◽  
Behavioral Sensitization

scholarly journals Changes in extracellular levels of glutamate in the nucleus accumbens after ethanol-induced behavioral sensitization in adolescent and adult mice

Alcohol ◽  
2011 ◽  
Vol 45 (5) ◽  
pp. 451-460 ◽  
Author(s):  
Priscila Fernandes Carrara-Nascimento ◽  
William C. Griffin ◽  
Daniel Mazzeo Pastrello ◽  
M. Foster Olive ◽  
Rosana Camarini
Keyword(s):  
Nucleus Accumbens ◽  
Behavioral Sensitization ◽  
Adult Mice

Alterations In Glutamate Synapses In The Nucleus Accumbens Following Sensitization To Cocaine

1999 ◽  
Vol 5 (S2) ◽  
pp. 1232-1233
Author(s):  
L. B. Kozell ◽  
C. K. Meshul
Keyword(s):  
Prefrontal Cortex ◽  
Locomotor Activity ◽  
Nucleus Accumbens ◽  
Behavioral Sensitization ◽  
Neural Mechanism ◽  
Cocaine Administration ◽  
Collaborative Studies ◽  
Abundant Evidence ◽  
Dopaminergic Pathways ◽  
Intermittent Cocaine

Repeated intermittent administration of cocaine to rodents has been shown to result in behavioral sensitization, or enhanced locomotor activity. Because there are similarities between effects of intermittent cocaine use in humans and sensitization in rats, understanding the neural mechanism underlying sensitization may provide insights into mechanisms of psychopathologies in humans.There is abundant evidence that the mesolimbic dopaminergic pathways, originating in the ventral tegmental area (VTA) and terminating in both nucleus accumbens (NAc) and prefrontal cortex (PFC), are critically important for development of sensitization to the motor-stimulating effects of cocaine. Evidence also suggests that changes in glutamate (Glu) transmission in the mesolimbic DA pathways are associated with sensitization to cocaine. In recent collaborative studies, we have shown that cocaine administration transiently decreases the density of nerve terminal glutamate immunolabeling within the NAc shell following withdrawal from continuous or intermittent cocaine administration. Locomotor activity was not assessed in either of these studies.

scholarly journals Alleviation of Methamphetamine Sensitization by Partially Lesioning Dopaminergic Terminals with 6-Hydroxydopamine in Nucleus Accumbens

2021 ◽  
Vol 30 ◽  
pp. 096368972110523
Author(s):  
Shu-Chun Chen ◽  
Hsi Chen ◽  
Seong-Jin Yu ◽  
Yun-Hsiang Chen ◽  
Yun Wang
Keyword(s):  
Nucleus Accumbens ◽  
Behavioral Sensitization ◽  
Study Drug ◽  
Behavioral Effect ◽  
Repeated Administration ◽  
Progressive Increase ◽  
Laboratory Model ◽  
Pcr Analysis ◽  
Abused Drugs ◽  
6 Hydroxydopamine

Amphetamine-type stimulants have become important and popular abused drugs worldwide. Methamphetamine (Meth) sensitization, characterized by a progressive increase in behavioral responses after repeated administration, has been reported in rodents and patients. This behavioral effect has been used as a laboratory model to study drug addiction and schizophrenia. The mesolimbic dopaminergic pathway plays a significant role in the development of Meth behavioral sensitization. Previous studies have reported that the ablation of nucleus accumbens (NAc) by electrolytic or thermal lesioning attenuates addictive behavior to opioids in animals. However, these studies were only conducted in opioid addictive rodents. Furthermore, these ablation procedures also damaged the non-dopaminergic neurons and fibers passing through the NAc. The purpose of this study was to examine the therapeutic effect of NAc lesioning by a selective dopaminergic toxin in Meth-sensitized animals. Adult mice received repeated administration of Meth for 7 days. Open-field locomotor activity and stereotype behavior were significantly increased after Meth treatment, suggesting behavior sensitization. A partial lesion of dopaminergic terminals was made through stereotaxic administration of dopaminergic toxin 6-hydroxydopamine (6-OHDA) to the NAc in the Meth -sensitized mice. Meth behavioral sensitization was significantly antagonized after the lesioning. Brain tissue was collected for qRT-PCR analysis. Repeated administration of Meth increased the expression of tyrosine hydroxylase (TH), BDNF, and Shati, a marker for Meth sensitization, in the NAc. Treatment with 6-OHDA significantly antagonized the upregulation of TH and Shati. Taken together, these data suggest that local administration of 6-OHDA mitigated Meth sensitization in chronic Meth-treated animals. Our data support a new surgical treatment strategy for Meth abuse.

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