scholarly journals Role of mPFC and nucleus accumbens circuitry in modulation of a nicotine plus alcohol compound drug state

2019 ◽  
Vol 25 (4) ◽  
Author(s):  
Patrick A. Randall ◽  
Zoe A. McElligott ◽  
Joyce Besheer
Keyword(s):  
Nucleus Accumbens ◽  
Drug State

scholarly journals The Role of Neuropeptide Y in the Nucleus Accumbens

2021 ◽  
Vol 22 (14) ◽  
pp. 7287
Author(s):  
Masaki Tanaka ◽  
Shunji Yamada ◽  
Yoshihisa Watanabe
Keyword(s):  
Nervous System ◽  
Nucleus Accumbens ◽  
Neuropeptide Y ◽  
Emotional Behavior ◽  
Characteristic Functions ◽  
Receptor Subtypes ◽  
Neuroendocrine Mechanisms ◽  
Fear And Anxiety ◽  
The Brain

Neuropeptide Y (NPY), an abundant peptide in the central nervous system, is expressed in neurons of various regions throughout the brain. The physiological and behavioral effects of NPY are mainly mediated through Y1, Y2, and Y5 receptor subtypes, which are expressed in regions regulating food intake, fear and anxiety, learning and memory, depression, and posttraumatic stress. In particular, the nucleus accumbens (NAc) has one of the highest NPY concentrations in the brain. In this review, we summarize the role of NPY in the NAc. NPY is expressed principally in medium-sized aspiny neurons, and numerous NPY immunoreactive fibers are observed in the NAc. Alterations in NPY expression under certain conditions through intra-NAc injections of NPY or receptor agonists/antagonists revealed NPY to be involved in the characteristic functions of the NAc, such as alcohol intake and drug addiction. In addition, control of mesolimbic dopaminergic release via NPY receptors may take part in these functions. NPY in the NAc also participates in fat intake and emotional behavior. Accumbal NPY neurons and fibers may exert physiological and pathophysiological actions partly through neuroendocrine mechanisms and the autonomic nervous system.

Role of nucleus accumbens microRNA-181a and MeCP2 in incubation of heroin craving in male rats

2021 ◽  
Author(s):  
Wenjin Xu ◽  
Qingxiao Hong ◽  
Zi Lin ◽  
Hong Ma ◽  
Weisheng Chen ◽  
...  
Keyword(s):  
Nucleus Accumbens ◽  
Male Rats

Role of beta-catenin and endocannabinoids in the nucleus accumbens in extinction in rats exposed to shock and reminders

Neuroscience ◽  
2017 ◽  
Vol 357 ◽  
pp. 285-294 ◽  
Author(s):  
Nachshon Korem ◽  
Rachel Lange ◽  
Cecilia J. Hillard ◽  
Irit Akirav
Keyword(s):  
Nucleus Accumbens ◽  
Beta Catenin

Role of the nucleus accumbens in social memory in rats

1991 ◽  
Vol 26 (1) ◽  
pp. 23-27 ◽  
Author(s):  
G.E. Ploeger ◽  
A.P.M. Willemen ◽  
A.R. Cools
Keyword(s):  
Nucleus Accumbens ◽  
Social Memory

scholarly journals Comparing the role of the anterior cingulate cortex and 6-hydroxydopamine nucleus accumbens lesions on operant effort-based decision making

2009 ◽  
Vol 29 (8) ◽  
pp. 1678-1691 ◽  
Author(s):  
Mark E. Walton ◽  
James Groves ◽  
Katie A. Jennings ◽  
Paula L. Croxson ◽  
Trevor Sharp ◽  
...  
Keyword(s):  
Decision Making ◽  
Nucleus Accumbens ◽  
Anterior Cingulate Cortex ◽  
Cingulate Cortex ◽  
Anterior Cingulate ◽  
6 Hydroxydopamine
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