scholarly journals Polysubstance addiction vulnerability in mental illness: Concurrent alcohol and nicotine self‐administration in the neurodevelopmental hippocampal lesion rat model of schizophrenia

2018 ◽  
Vol 25 (1) ◽  
Author(s):  
Alena M. Sentir ◽  
Richard L. Bell ◽  
Eric A. Engleman ◽  
R. Andrew Chambers
Keyword(s):  
Mental Illness ◽  
Rat Model ◽  
Hippocampal Lesion ◽  
Self Administration

scholarly journals Prelimbic cortex is a common brain area activated during cue-induced reinstatement of cocaine and heroin seeking in a polydrug self-administration rat model

2018 ◽  
Vol 49 (2) ◽  
pp. 165-178 ◽  
Author(s):  
Francisco J. Rubio ◽  
Richard Quintana-Feliciano ◽  
Brandon L. Warren ◽  
Xuan Li ◽  
Kailyn F. R. Witonsky ◽  
...  
Keyword(s):  
Rat Model ◽  
Brain Area ◽  
Prelimbic Cortex ◽  
Self Administration

Using anticipatory and drug-evoked appetitive ultrasonic vocalization for monitoring the rewarding effect of amphetamine in a rat model of drug self-administration

2019 ◽  
Vol 376 ◽  
pp. 112187 ◽  
Author(s):  
Karolina Kuchniak ◽  
Edyta Wyszogrodzka ◽  
Stanisław J. Chrapusta ◽  
Magdalena Czarna ◽  
Magdalena Michalak ◽  
...  
Keyword(s):  
Rat Model ◽  
Ultrasonic Vocalization ◽  
Self Administration ◽  
Rewarding Effect

Intravenous self-administration of amphetamine is increased in a rat model of depression

Synapse ◽  
2002 ◽  
Vol 46 (1) ◽  
pp. 4-10 ◽  
Author(s):  
Philip V. Holmes ◽  
Cher V. Masini ◽  
Stefany D. Primeaux ◽  
Joshua L. Garrett ◽  
Andrew Zellner ◽  
...  
Keyword(s):  
Rat Model ◽  
Self Administration

2Hz-Electroacupuncture Attenuates Conditioned Cue-Evoked Heroin-Seeking Behavior and Increase CB2-Rs Expression in Relapse-Relevant Brain Regions in Heroin-Addicted Rats

2014 ◽  
Vol 998-999 ◽  
pp. 164-168 ◽  
Author(s):  
Lin Chen ◽  
Bao Miao Ma ◽  
Kai Yue ◽  
Qin Ru ◽  
Xiang Tian ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Nucleus Accumbens ◽  
Rat Model ◽  
Fixed Ratio ◽  
Brain Regions ◽  
Inhibitory Effect ◽  
Control Group ◽  
Self Administration ◽  
Seeking Behavior

In order to investigate the influence of electroacupuncture on heroin seeking behavior and the expression of CB2-Rs in the relapse-relevant brain regions, heroin self-administration rat model which represents the heroin relapse behaviors was developed with progressive fixed ratio program. The model rats were randomly divided into 3 groups: control group, heroin-addicted group and 2Hz electroacupuncture group (stimulating on acupoints zusanli and sanyinjiao). The expression of CB2-Rs in the relapse-relevant brain regions were assessed with immunohistochemistry technologies. The reinstatement of heroin seeking behavior induced by conditioned cue priming showed that compared with the heroin-addicted group, active pokes in the 2Hz electroacupuncture group decreased significantly (p<0.05). Compared with the control group, the expression of CB2-Rs in prefrontal cortex (PFC) and nucleus accumbens (NAc) was significantly decreased (p<0.05) in heroin-addicted group and increaseed significantly recover (p<0.05) in the 2Hz electroacupuncture group. Our present results showed that 2Hz-electroacupuncture could attenuate the conditioned cue-evoked heroin-seeking behavior and the inhibitory effect was mediated partially by the increase CB2-Rs expression in relapse-relevant brain regions in heroin-addicted rats.

scholarly journals Nicotine effects in adolescence and adulthood on cognition and α4β2-nicotinic receptors in the neonatal ventral hippocampal lesion rat model of schizophrenia

2014 ◽  
Vol 232 (10) ◽  
pp. 1681-1692 ◽  
Author(s):  
Sarah A. Berg ◽  
Alena M. Sentir ◽  
Richard L. Bell ◽  
Eric A. Engleman ◽  
R. Andrew Chambers
Keyword(s):  
Rat Model ◽  
Hippocampal Lesion ◽  
Nicotinic Receptors ◽  
Neonatal Ventral Hippocampal Lesion

Suppression of Methamphetamine Self-Administration by Ketamine Pre-treatment Is Absent in the Methylazoxymethanol (MAM) Rat Model of Schizophrenia

2017 ◽  
Vol 32 (1) ◽  
pp. 121-133 ◽  
Author(s):  
Jana Ruda-Kucerova ◽  
Zuzana Babinska ◽  
Tibor Stark ◽  
Vincenzo Micale
Keyword(s):  
Rat Model ◽  
Self Administration ◽  
Pre Treatment

scholarly journals Allosteric modulation of GABAA receptors in rat basolateral amygdala blocks stress-enhanced reacquisition of nicotine self-administration

2020 ◽  
Author(s):  
Burt M Sharp ◽  
Qin Jiang ◽  
Xenia Simone ◽  
Petra Scholze
Keyword(s):  
Rat Model ◽  
Gabaa Receptors ◽  
Basolateral Amygdala ◽  
Allosteric Modulation ◽  
Gabaergic Interneurons ◽  
Allosteric Modulators ◽  
Self Administration ◽  
Repeated Stress ◽  
Output Neurons ◽  
Inhibitory Regulation

AbstractStress is a major determinant of relapse to smoked tobacco. In a rat model, repeated stress during abstinence from nicotine self-administration (SA) results in enhanced reacquisition of nicotine SA, which is dependent on the basolateral amygdala (BLA). We postulate that repeated stress during abstinence causes hyperexcitability of BLA principal output neurons (PN) due to disinhibition of PN from reduced inhibitory regulation by local GABAergic interneurons. To determine if enhanced GABAergic regulation of BLA PNs can lessen the effects of stress on nicotine intake, positive allosteric modulators (PAMs) of GABAA receptors were infused into the BLA immediately prior to reacquisition of nicotine SA. Three selective PAMs (e.g., NS 16085, DCUK-OEt, DS2) with varied GABAA subunit specificities abolished the stress-induced amplification of nicotine taking during reacquisition. These studies indicate that highly selective PAMS targeting α3 or δ subunit-containing GABAA in BLA may be effective in ameliorating the stress-induced relapse to smoked tobacco during abstinence from cigarettes.

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