Pilot randomized placebo‐controlled clinical trial of high‐dose gabapentin for alcohol use disorder

2021 ◽  
Author(s):  
John J. Mariani ◽  
Martina Pavlicova ◽  
Cale Basaraba ◽  
Agnieszka Mamczur‐Fuller ◽  
Daniel J. Brooks ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Alcohol Use ◽  
Alcohol Use Disorder ◽  
Controlled Clinical Trial ◽  
High Dose

scholarly journals A Randomized, Placebo-controlled, Clinical Trial of Prazosin for the Treatment of Alcohol Use Disorder

2018 ◽  
Vol 12 (5) ◽  
pp. 339-345 ◽  
Author(s):  
Claire E. Wilcox ◽  
J. Scott Tonigan ◽  
Michael P. Bogenschutz ◽  
Joshua Clifford ◽  
Rose Bigelow ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Alcohol Use ◽  
Alcohol Use Disorder ◽  
Controlled Clinical Trial

DSM-5 alcohol use disorder features among treatment-seeking older adults

2018 ◽  
Vol 64 (4) ◽  
pp. 185-196 ◽  
Author(s):  
Silke Behrendt ◽  
Barbara Braun ◽  
Randi Bilberg ◽  
Gerhard Bühringer ◽  
Michael Bogenschutz ◽  
...  
Keyword(s):  
Older Adults ◽  
Alcohol Use ◽  
Alcohol Use Disorder ◽  
The Elderly ◽  
Treatment Seeking ◽  
Controlled Clinical Trial ◽  
Dsm 5 ◽  
Wide Range ◽  
And Gender ◽  
International Multicenter

Abstract. Background: The number of older adults with alcohol use disorder (AUD) is expected to rise. Adapted treatments for this group are lacking and information on AUD features in treatment seeking older adults is scarce. The international multicenter randomized-controlled clinical trial “ELDERLY-Study” with few exclusion criteria was conducted to investigate two outpatient AUD-treatments for adults aged 60+ with DSM-5 AUD. Aims: To add to 1) basic methodological information on the ELDERLY-Study by providing information on AUD features in ELDERLY-participants taking into account country and gender, and 2) knowledge on AUD features in older adults seeking outpatient treatment. Methods: baseline data from the German and Danish ELDERLY-sites (n=544) were used. AUD diagnoses were obtained with the Mini International Neuropsychiatric Interview, alcohol use information with Form 90. Results: Lost control, desired control, mental/physical problem, and craving were the most prevalent (> 70 %) AUD-symptoms. 54.9 % reported severe DSM-5 AUD (moderate: 28.2 %, mild: 16.9 %). Mean daily alcohol use was 6.3 drinks at 12 grams ethanol each. 93.9 % reported binging. More intense alcohol use was associated with greater AUD-severity and male gender. Country effects showed for alcohol use and AUD-severity. Conclusion: European ELDERLY-participants presented typical dependence symptoms, a wide range of severity, and intense alcohol use. This may underline the clinical significance of AUD in treatment-seeking seniors.

scholarly journals Longitudinal Findings from a Randomized Clinical Trial of Varenicline for Alcohol Use Disorder with Comorbid Cigarette Smoking

2019 ◽  
Vol 43 (5) ◽  
pp. 937-944 ◽  
Author(s):  
Krysten W. Bold ◽  
Allen Zweben ◽  
Lisa M. Fucito ◽  
Mary E. Piepmeier ◽  
Srinivas Muvvala ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Alcohol Use ◽  
Cigarette Smoking ◽  
Randomized Clinical Trial ◽  
Alcohol Use Disorder

scholarly journals High-dose intravenous versus oral iron in blood donors with iron deficiency: The IronWoMan randomized, controlled clinical trial

2020 ◽  
Vol 39 (3) ◽  
pp. 737-745 ◽  
Author(s):  
Camilla Drexler ◽  
Susanne Macher ◽  
Ines Lindenau ◽  
Magdalena Holter ◽  
Martina Moritz ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Iron Deficiency ◽  
Blood Donors ◽  
Oral Iron ◽  
Controlled Clinical Trial ◽  
High Dose ◽  
Randomized Controlled Clinical Trial ◽  
Randomized Controlled

A Controlled Clinical Trial of High-Dose Methylprednisolone in the Treatment of Severe and Septic Shock

1988 ◽  
Vol 32 (2) ◽  
pp. 125???127
Author(s):  
R. C. BONE ◽  
C. J. FISHER ◽  
T. P. CLEMMER ◽  
G. J. SLOTMAN ◽  
C. A. METZ ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Septic Shock ◽  
Controlled Clinical Trial ◽  
High Dose ◽  
High Dose Methylprednisolone
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