Alcohol Use Disorder Masks the Effects of Childhood Adversity, Lifetime Trauma, and Chronic Stress on Hypothalamic–Pituitary–Adrenal Axis Reactivity

2020 ◽  
Vol 44 (6) ◽  
pp. 1192-1203
Author(s):  
Alice Zhang ◽  
Julianne L. Price ◽  
David Leonard ◽  
Carol S. North ◽  
Alina Suris ◽  
...  
Keyword(s):  
Alcohol Use ◽  
Chronic Stress ◽  
Alcohol Use Disorder ◽  
Childhood Adversity ◽  
Hypothalamic Pituitary Adrenal Axis ◽  
Hypothalamic Pituitary Adrenal ◽  
Adrenal Axis ◽  
Lifetime Trauma ◽  
Pituitary Adrenal Axis

Hypothalamic-pituitary-adrenal axis, childhood adversity and adolescent nonsuicidal self-injury

2016 ◽  
Vol 74 ◽  
pp. 203-211 ◽  
Author(s):  
Corinna Reichl ◽  
Anne Heyer ◽  
Romuald Brunner ◽  
Peter Parzer ◽  
Julia Madeleine Völker ◽  
...  
Keyword(s):  
Childhood Adversity ◽  
Hypothalamic Pituitary Adrenal Axis ◽  
Hypothalamic Pituitary Adrenal ◽  
Adrenal Axis ◽  
Self Injury ◽  
Pituitary Adrenal Axis ◽  
Nonsuicidal Self Injury

Childhood adversity and allostatic overload of the hypothalamic–pituitary–adrenal axis: A vulnerability model for depressive disorders

2011 ◽  
Vol 23 (4) ◽  
pp. 1017-1037 ◽  
Author(s):  
Paul O. Wilkinson ◽  
Ian M. Goodyer
Keyword(s):  
Depressive Disorders ◽  
Epigenetic Modification ◽  
Childhood Adversity ◽  
Hypothalamic Pituitary Adrenal Axis ◽  
Neural Systems ◽  
Hypothalamic Pituitary Adrenal ◽  
Adrenal Axis ◽  
Increased Risk ◽  
Depressive Episodes ◽  
Pituitary Adrenal Axis

AbstractChildhood adversity is associated with increased risk for onset of depressive episodes. This review will present evidence that allostatic overload of the hypothalamic–pituitary–adrenal axis (HPAA) partially mediates this association. The HPAA is the physiological system that regulates levels of the stress hormone cortisol. First, data from animals and humans has shown that early environmental adversity is associated with long-term dysregulation of the HPAA. This may occur due to permanent epigenetic modification of the glucocorticoid receptor. Second, data from humans has demonstrated that HPAA dysregulation is associated with increased risk of future depression onset in healthy individuals, and pharmacological correction of HPAA dysregulation reduces depressive symptoms. HPAA dysregulation may result in corticoid-mediated abnormalities in neurogenesis in early life and/or neurotoxicity on neural systems that subserve emotion and cognition.

The Hypothalamic-Pituitary-Adrenal Axis, Obesity, and Chronic Stress Exposure: Foods and HPA Axis

2012 ◽  
Vol 1 (4) ◽  
pp. 199-207 ◽  
Author(s):  
Femke Rutters ◽  
Susanne La Fleur ◽  
Sofie Lemmens ◽  
Jurriaan Born ◽  
Mieke Martens ◽  
...  
Keyword(s):  
Chronic Stress ◽  
Hpa Axis ◽  
Hypothalamic Pituitary Adrenal Axis ◽  
Stress Exposure ◽  
Hypothalamic Pituitary Adrenal ◽  
Adrenal Axis ◽  
Pituitary Adrenal Axis

scholarly journals Sensitization of the Hypothalamic-Pituitary-Adrenal Axis in a Male Rat Chronic Stress Model

Endocrinology ◽  
2016 ◽  
Vol 157 (6) ◽  
pp. 2346-2355 ◽  
Author(s):  
Alier J. Franco ◽  
Chun Chen ◽  
Tyler Scullen ◽  
Andrea Zsombok ◽  
Ahmed A. Salahudeen ◽  
...  
Keyword(s):  
Chronic Stress ◽  
Hypothalamic Pituitary Adrenal Axis ◽  
Male Rat ◽  
Stress Model ◽  
Hypothalamic Pituitary Adrenal ◽  
Adrenal Axis ◽  
Pituitary Adrenal Axis

scholarly journals Stress History and Pubertal Development Interact to Shape Hypothalamic-Pituitary-Adrenal Axis Plasticity

Endocrinology ◽  
2006 ◽  
Vol 147 (4) ◽  
pp. 1664-1674 ◽  
Author(s):  
Russell D. Romeo ◽  
Rudy Bellani ◽  
Ilia N. Karatsoreos ◽  
Nara Chhua ◽  
Mary Vernov ◽  
...  
Keyword(s):  
Stress Response ◽  
Chronic Stress ◽  
Arginine Vasopressin ◽  
Hypothalamic Pituitary Adrenal Axis ◽  
Male Rats ◽  
Pubertal Maturation ◽  
Hypothalamic Pituitary Adrenal ◽  
Adrenal Axis ◽  
Acute And Chronic Stress ◽  
Pituitary Adrenal Axis

Both the magnitude and the duration of the hormonal stress response change dramatically during neonatal development and aging as well as with prior experience with a stressor. However, surprisingly little is known with regard to how pubertal maturation and experience with stress interact to affect hypothalamic-pituitary-adrenal axis responsiveness. Because adolescence is a period of neurodevelopmental vulnerabilities and opportunities that may be especially sensitive to stress, it is imperative to more fully understand these interactions. Thus, we examined hormonal and neural responses in prepubertal (28 d of age) and adult (77 d of age) male rats after exposure to acute (30 min) or more chronic (30 min/d for 7 d) restraint stress. We report here that after acute stress, prepubertal males exhibited a significantly prolonged hormonal stress response (e.g. ACTH and total and free corticosterone) compared with adults. In contrast, after chronic stress, prepubertal males exhibited a higher response immediately after the stressor, but a faster return to baseline, compared with adults. Additionally, we demonstrate that this differential stress reactivity is associated with differential neuronal activation in the paraventricular nucleus of the hypothalamus, as measured by FOS immunohistochemistry. Using triple-label immunofluorescence histochemistry, we found that a larger proportion of CRH, but not arginine vasopressin, cells are activated in the arginine vasopressin in response to both acute and chronic stress in prepubertal animals compared with adults. These data indicate that experience-dependent plasticity of the hypothalamic-pituitary-adrenal neuroendocrine axis is significantly influenced by pubertal maturation.

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