scholarly journals Getting to the Heart of Low Sensitivity to Alcohol: Context Moderates Low Cardiovascular Response to Alcohol in Persons With a Family History of Alcohol Use Disorder

2020 ◽  
Vol 44 (3) ◽  
pp. 589-599
Author(s):  
Marsha E. Bates ◽  
Eun‐Young Mun ◽  
Jennifer F. Buckman ◽  
Evgeny Vaschillo ◽  
Bronya Vaschillo ◽  
...  
Keyword(s):  
Family History ◽  
Alcohol Use ◽  
Alcohol Use Disorder ◽  
Cardiovascular Response ◽  
History Of ◽  
Low Sensitivity

scholarly journals The role of pubertal timing in the link between family history of alcohol use disorder and late adolescent substance use

2020 ◽  
Vol 210 ◽  
pp. 107955
Author(s):  
Alexander S. Weigard ◽  
Jillian E. Hardee ◽  
Robert A. Zucker ◽  
Mary M. Heitzeg ◽  
Adriene M. Beltz
Keyword(s):  
Substance Use ◽  
Family History ◽  
Alcohol Use ◽  
Alcohol Use Disorder ◽  
Pubertal Timing ◽  
Adolescent Substance Use ◽  
Late Adolescent ◽  
Adolescent Substance ◽  
History Of

scholarly journals Family history of alcohol use disorder is associated with brain structural and functional changes in healthy first-degree relatives

2019 ◽  
Vol 62 ◽  
pp. 107-115 ◽  
Author(s):  
Irina Filippi ◽  
Nicolas Hoertel ◽  
Eric Artiges ◽  
Guillaume Airagnes ◽  
Christophe Guérin-Langlois ◽  
...  
Keyword(s):  
Family History ◽  
Alcohol Use ◽  
Childhood Maltreatment ◽  
Alcohol Use Disorder ◽  
Grey Matter ◽  
Brain Regions ◽  
Whole Brain ◽  
Childhood Trauma Questionnaire ◽  
Functional Changes ◽  
History Of

Abstract Background: Neuroimaging studies of vulnerability to Alcohol Use Disorder (AUD) have identified structural and functional variations which might reflect inheritable features in alcohol-naïve relatives of AUD individuals (FH+) compared to controls having no such family history (FH-). However, prior research did not simultaneously account for childhood maltreatment, any clinically significant disorder and maternal AUD. Therefore, we mainly aimed to investigate the brain structure and reward-related neural activations (fMRI), using whole-brain analysis in FH+ young adults with no prevalent confounders. Methods: 46 FH+ and 45 FH- male and female participants had no severe childhood maltreatment exposure, neither any psychiatric disorder or AUD, nor a prenatal exposure to maternal AUD. We used a 3 T MRI coupled with a whole brain voxel-based method to compare between groups the grey matter volumes and activations in response to big versus small wins during a Monetary Incentive Delay task. The Childhood Trauma Questionnaire score was used as confounding variable in the analyses to account for the remaining variance between groups. Results: Compared to FH- controls, FH+ participants had smaller grey matter volumes in the frontal and cingulate regions as well as in the bilateral nucleus accumbens and right insula. The FH+ participants’ fMRI datasets denoted a blunted activation in the middle cingulum with respect to FH- controls’ during the processing of reward magnitude, and a greater activation in the anterior cingulum in response to anticipation of a small win. Conclusions: Family history of alcohol use disorder is linked to structural and functional variations including brain regions involved in reward processes.

Family History of Alcohol Abuse Associated with Higher Impulsivity in Patients with Alcohol Use Disorder: A Multisite Study

2020 ◽  
Vol 26 (2) ◽  
pp. 85-95 ◽  
Author(s):  
Lotfi Khemiri ◽  
Anne Marije Kaag ◽  
Leen Joos ◽  
Geert Dom ◽  
Johan Franck ◽  
...  
Keyword(s):  
Family History ◽  
Alcohol Use ◽  
Alcohol Abuse ◽  
Alcohol Use Disorder ◽  
History Of

scholarly journals Cortical Thickness in Adolescents with a Family History of Alcohol Use Disorder

2017 ◽  
Vol 42 (1) ◽  
pp. 89-99 ◽  
Author(s):  
Kate E. Henderson ◽  
Jatin G. Vaidya ◽  
John R. Kramer ◽  
Samuel Kuperman ◽  
Douglas R. Langbehn ◽  
...  
Keyword(s):  
Family History ◽  
Alcohol Use ◽  
Cortical Thickness ◽  
Alcohol Use Disorder ◽  
History Of

scholarly journals Environmental influences predominate in remission from alcohol use disorder in young adult twins

2012 ◽  
Vol 42 (11) ◽  
pp. 2421-2431 ◽  
Author(s):  
V. V. McCutcheon ◽  
J. D. Grant ◽  
A. C. Heath ◽  
K. K. Bucholz ◽  
C. E. Sartor ◽  
...  
Keyword(s):  
Young Adult ◽  
Family History ◽  
Alcohol Use ◽  
Alcohol Use Disorder ◽  
Telephone Interview ◽  
Environmental Influences ◽  
Familial Influences ◽  
History Of ◽  
Adult Twins ◽  
Alcohol Abuse And Dependence

BackgroundFamilial influences on remission from alcohol use disorder (AUD) have been studied using family history of AUD rather than family history of remission. The current study used a remission phenotype in a twin sample to examine the relative contributions of genetic and environmental influences to remission.MethodThe sample comprised 6183 twins with an average age of 30 years from the Australian Twin Registry. Lifetime history of alcohol abuse and dependence symptoms and symptom recency were assessed with a structured telephone interview. AUD was defined broadly and narrowly as history of two or more or three or more abuse or dependence symptoms. Remission was defined as absence of symptoms at time of interview among individuals with lifetime AUD. Standard bivariate genetic analyses were conducted to derive estimates of genetic and environmental influences on AUD and remission.ResultsEnvironmental influences alone accounted for remission in males and for 89% of influences on remission in females, with 11% due to genetic influences shared with AUD, which decreased the likelihood of remission. For women, more than 80% of influences on remission were distinct from influences on AUD, and environmental influences were from individual experiences only. For men, just over 50% of influences on remission were distinct from those on AUD, and the influence of environments shared with the co-twin were substantial. The results for the broad and narrow phenotypes were similar.ConclusionsThe current study establishes young adult remission as a phenotype distinct from AUD and highlights the importance of environmental influences on remission.

Examining interactions between genetic risk for alcohol problems, peer deviance, and interpersonal traumatic events on trajectories of alcohol use disorder symptoms among African American college students

2018 ◽  
Vol 30 (5) ◽  
pp. 1749-1761 ◽  
Author(s):  
Jinni Su ◽  
Sally I-Chun Kuo ◽  
Jacquelyn L. Meyers ◽  
Mignonne C. Guy ◽  
Danielle M. Dick
Keyword(s):  
African American ◽  
Family History ◽  
Alcohol Use ◽  
Genetic Risk ◽  
Alcohol Use Disorder ◽  
Traumatic Events ◽  
Alcohol Problems ◽  
Risk Scores ◽  
Peer Deviance ◽  
History Of

AbstractNumerous studies have demonstrated that genetic and environmental factors interact to influence alcohol problems. Yet prior research has primarily focused on samples of European descent and little is known about gene–environment interactions in relation to alcohol problems in non-European populations. In this study, we examined whether and how genetic risk for alcohol problems and peer deviance and interpersonal traumatic events independently and interactively influence trajectories of alcohol use disorder symptoms in a sample of African American students across the college years (N = 1,119; Mage= 18.44 years). Data were drawn from the Spit for Science study where participants completed multiple online surveys throughout college and provided a saliva sample for genotyping. Multilevel growth curve analyses indicated that alcohol dependence genome-wide polygenic risk scores did not predict trajectory of alcohol use disorder symptoms, while family history of alcohol problems was associated with alcohol use disorder symptoms at the start of college but not with the rate of change in symptoms over time. Peer deviance and interpersonal traumatic events were associated with more alcohol use disorder symptoms across college years. Neither alcohol dependence genome-wide polygenic risk scores nor family history of alcohol problems moderated the effects of these environmental risk factors on alcohol use disorder symptoms. Our findings indicated that peer deviance and experience of interpersonal traumatic events are salient risk factors that elevate risk for alcohol problems among African American college students. Family history of alcohol problems could be a useful indicator of genetic risk for alcohol problems. Gene identification efforts with much larger samples of African descent are needed to better characterize genetic risk for alcohol use disorders, in order to better understand gene–environment interaction processes in this understudied population.

scholarly journals Ketamine’s Antidepressant Efficacy is Extended for at Least Four Weeks in Subjects with a Family History of an Alcohol Use Disorder

2014 ◽  
Vol 18 (1) ◽  
Author(s):  
Mark J. Niciu ◽  
David A. Luckenbaugh ◽  
Dawn F. Ionescu ◽  
Erica M. Richards ◽  
Jennifer L. Vande Voort ◽  
...  
Keyword(s):  
Family History ◽  
Alcohol Use ◽  
Alcohol Use Disorder ◽  
Antidepressant Efficacy ◽  
History Of
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