scholarly journals Reduced Serum Osteocalcin in High‐Risk Alcohol Using People Living With HIV Does Not Correlate With Systemic Oxidative Stress or Inflammation: Data From the New Orleans Alcohol Use in HIV Study

2019 ◽  
Vol 43 (11) ◽  
pp. 2374-2383 ◽  
Author(s):  
James Watt ◽  
Jonathan Schuon ◽  
Jacob Davis ◽  
Tekeda F. Ferguson ◽  
David A. Welsh ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
High Risk ◽  
Alcohol Use ◽  
New Orleans ◽  
People Living With Hiv ◽  
Serum Osteocalcin ◽  
Systemic Oxidative Stress ◽  
Living With Hiv

scholarly journals Comprehensive Assessment of Alcohol Consumption in People Living with HIV (PLWH): The New Orleans Alcohol Use in HIV Study

2020 ◽  
Vol 44 (6) ◽  
pp. 1261-1272 ◽  
Author(s):  
Tekeda F. Ferguson ◽  
Katherine P. Theall ◽  
Meghan Brashear ◽  
Vincent Maffei ◽  
Alaina Beauchamp ◽  
...  
Keyword(s):  
Alcohol Consumption ◽  
Alcohol Use ◽  
New Orleans ◽  
Comprehensive Assessment ◽  
People Living With Hiv ◽  
Living With Hiv

scholarly journals HIV Stigma, Mental Health, and Alcohol Use Disorders among People Living with HIV/AIDS in New Orleans

2019 ◽  
Vol 96 (6) ◽  
pp. 878-888 ◽  
Author(s):  
Erica A. Felker-Kantor ◽  
Maeve E. Wallace ◽  
Aubrey Spriggs Madkour ◽  
Dustin T. Duncan ◽  
Katherine Andrinopoulos ◽  
...  
Keyword(s):  
Mental Health ◽  
Alcohol Use ◽  
New Orleans ◽  
Alcohol Use Disorders ◽  
Hiv Stigma ◽  
People Living With Hiv ◽  
Living With Hiv ◽  
Hiv Aids

scholarly journals Associations of Liver Disease with Alcohol Use among People Living with HIV and the Role of Hepatitis C: The New Orleans Alcohol Use in HIV Study

2019 ◽  
Vol 55 (1) ◽  
pp. 28-36 ◽  
Author(s):  
Tekeda F Ferguson ◽  
Erika Rosen ◽  
Rotonya Carr ◽  
Meghan Brashear ◽  
Liz Simon ◽  
...  
Keyword(s):  
Liver Disease ◽  
Hepatitis C ◽  
Alcohol Use ◽  
New Orleans ◽  
People Living With Hiv ◽  
Hiv Viral Load ◽  
Cross Sectional ◽  
Nonalcoholic Fatty Liver ◽  
Logistic Regression Models ◽  
Living With Hiv

Abstract Aim This cross-sectional analysis of the New Orleans Alcohol Use in HIV (NOAH) study assesses whether current and lifetime alcohol use in people living with HIV (PLWH) are associated with greater liver disease and how hepatitis C-viral (HCV) co-infection (HIV/HCV+) modifies the association. Methods Alcohol use was measured by Lifetime Drinking History (LDH), a 30-day Timeline Followback calendar, the Alcohol Use Disorder Identification Test, and phosphatidylethanol. Liver disease was estimated by alanine aminotransferase (ALT), aspartate aminotransferase (AST), AST platelet ratio-index (APRI), fibrosis-4 index (FIB-4) and nonalcoholic fatty liver disease-fibrosis score. Associations between alcohol consumption and liver disease were estimated with multivariable logistic regression. Models were adjusted for age, sex, body-mass index, hepatitis B and HIV viral load. Results Participants (N = 353) were majority male (69%) and black (84%) with a mean age of 48.3 ± 10 years. LDH was significantly associated with advanced liver fibrosis (FIB-4 aOR = 22.22 [1.22–403.72]) only among HIV/HCV+ participants with an LDH of 100–600 kg. HIV/HCV+ participants had a higher prevalence of intermediate and advanced liver disease markers than HIV/HCV− (P < 0.0001). Advanced markers of liver disease were most strongly associated with hazardous drinking (≥40(women)/60(men) grams/day) (APRI aOR = 15.87 (3.22–78.12); FIB-4 aOR = 6.76 (1.81–7.16)) and PEth ≥400 ng/ml (APRI aOR = 17.52 (2.55–120.54); FIB-4 aOR = 17.75 (3.30–95.630). Conclusion Results indicate a greater association of current alcohol use with liver disease than lifetime alcohol use, which varied by HCV status. These findings stress the importance of reducing alcohol use in PLWH to decrease risk of liver disease and fibrosis.

Negative Consequences of Alcohol Use among People Living with HIV

2021 ◽  
pp. 1-8
Author(s):  
Rebecca J. Fisk ◽  
Veronica L. Richards ◽  
Robert F. Leeman ◽  
Babette Brumback ◽  
Christa Cook ◽  
...  
Keyword(s):  
Alcohol Use ◽  
People Living With Hiv ◽  
Negative Consequences ◽  
Living With Hiv

scholarly journals Depression, suicidality, and alcohol use disorder among people living with HIV/AIDS in Nigeria

2017 ◽  
Vol 17 (1) ◽  
Author(s):  
Catherine O. Egbe ◽  
Patrick S. Dakum ◽  
Ernest Ekong ◽  
Brandon A. Kohrt ◽  
John G. Minto ◽  
...  
Keyword(s):  
Alcohol Use ◽  
Alcohol Use Disorder ◽  
People Living With Hiv ◽  
Living With Hiv ◽  
Hiv Aids

Unique Circulating MicroRNA Associations with Dysglycemia in People Living with HIV and Alcohol Use

2021 ◽  
Author(s):  
Brianna L Bourgeois ◽  
Hui-Yi Lin ◽  
Alice Y Yeh ◽  
Danielle E. Levitt ◽  
Stefany DePrato Primeaux ◽  
...  
Keyword(s):  
Alcohol Use ◽  
Tolerance Test ◽  
Oral Glucose ◽  
Circulating Microrna ◽  
People Living With Hiv ◽  
Regression Analyses ◽  
Circulating Micrornas ◽  
Altered Glucose ◽  
Function Correlation ◽  
Living With Hiv

People living with HIV (PLWH) have increased prevalence of comorbid conditions including insulin resistance and at-risk alcohol use. Circulating microRNAs (miRs) may serve as minimally invasive indicators of pathophysiological states. We aimed to identify whether alcohol modulates circulating miR associations with measures of glucose/insulin dynamics in PLWH. PLWH (N=96; 69.8% male) enrolled in the Alcohol & Metabolic Comorbidities in PLWH: Evidence-Driven Interventions (ALIVE-Ex) study were stratified into negative phosphatidylethanol (PEth<8ng/ml, N=42) and positive PEth (PEth≥8ng/ml, N=54) groups. An oral glucose tolerance test (OGTT) was administered, and total RNA was isolated from fasting plasma to determine absolute miR expression. Circulating miRs were selected based on their role in skeletal muscle (miR-133a, miR-206), pancreatic β-cell (miR-375), liver (miR-20a), and adipose tissue (miR-let-7b, miR-146a, miR-221) function. Correlation and multiple regression analyses between miR expression and adiponectin, 2h glucose, insulin, and C-peptide values were performed adjusting for BMI category, age, sex, and viral load. miR-133a was negatively associated with adiponectin (p=0.002) in the negative PEth group, and miR-20a was positively associated with 2h glucose (p=0.013) in the positive PEth group. Regression analyses combining miRs demonstrated that miR-133a (p<0.001) and miR-221 (p=0.010) together predicted adiponectin in the negative PEth group. miR-20a (p<0.001) and miR-375 (p=0.002) together predicted 2h glucose in the positive PEth group. Our results indicate that associations between miRs and measures of glucose/insulin dynamics differed between PEth groups suggesting that the pathophysiological mechanisms contributing to altered glucose homeostasis in PLWH are potentially modulated by alcohol use.

Urgent need to address the slow scale-up of TB preventive treatment in the WHO South-East Asia Region

2021 ◽  
Vol 25 (5) ◽  
pp. 382-387
Author(s):  
S. Satyanarayana ◽  
V. Bhatia ◽  
P. P. Mandal ◽  
A. Kanchar ◽  
D. Falzon ◽  
...  
Keyword(s):  
High Risk ◽  
East Asia ◽  
Scale Up ◽  
Preventive Treatment ◽  
People Living With Hiv ◽  
South East Asia ◽  
High Level ◽  
Almost All ◽  
Living With Hiv ◽  
East Asia Region

In September 2018, all countries made a commitment at the first ever United Nations High‐Level Meeting (UNHLM) on TB, to provide TB preventive treatment (TPT) to at least 30 million people at high‐risk of TB disease between 2018 and 2022. In the WHO South‐East Asia Region (SEA Region), which accounts for 44% of the global TB burden, only 1.2 million high‐risk individuals (household contacts and people living with HIV) were provided TPT (11% of the 10.8 million regional UNHLM TPT target) in 2018 and 2019. By 2020, almost all 11 countries of the SEA Region had revised their policies on TPT target groups and criteria to assess TPT eligibility, and had adopted at least one shorter TPT regimen recommended in the latest WHO TPT guidelines. The major challenges for TPT scale‐up in the SEA Region are resource shortages, knowledge and service delivery/uptake gaps among providers and service recipients, and the lack of adequate quantities of rifapentine for use in shorter TPT regimens. There are several regional opportunities to address these gaps and countries of the SEA Region must make use of these opportunities to scale up TPT services rapidly to reduce the TB burden in the SEA Region.

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