scholarly journals Ethanol Exposure Impairs AMPK Signaling and Phagocytosis in Human Alveolar Macrophages: Role of Ethanol Metabolism

2019 ◽  
Vol 43 (8) ◽  
pp. 1682-1694 ◽  
Author(s):  
Lata Kaphalia ◽  
Mukund P. Srinivasan ◽  
Ramu D. Kakumanu ◽  
Bhupendra S. Kaphalia ◽  
William J. Calhoun
Keyword(s):  
Alveolar Macrophages ◽  
Ethanol Exposure ◽  
Ethanol Metabolism ◽  
Ampk Signaling ◽  
Human Alveolar Macrophages

Interleukin-8 Gene Expression from Human Alveolar Macrophages: The Role of Adherence

1991 ◽  
Vol 5 (6) ◽  
pp. 579-585 ◽  
Author(s):  
Theodore J. Standiford ◽  
Steven L Kunkel ◽  
Keita Kasahara ◽  
Marc J. Milia ◽  
Mark W. Rolfe ◽  
...  
Keyword(s):  
Gene Expression ◽  
Alveolar Macrophages ◽  
Interleukin 8 ◽  
Human Alveolar Macrophages

Elastin Degradation by Human Alveolar Macrophages: A Prominent Role of Metalloproteinase Activity

1989 ◽  
Vol 139 (5) ◽  
pp. 1251-1256 ◽  
Author(s):  
Robert M. Senior ◽  
Noreen L. Connolly ◽  
James D. Cury ◽  
Howard G. Welgus ◽  
Edward J. Campbell
Keyword(s):  
Alveolar Macrophages ◽  
Elastin Degradation ◽  
Human Alveolar Macrophages ◽  
Metalloproteinase Activity

Hypoxia triggers an antimicrobial pathway in human alveolar macrophages

Pneumologie ◽  
2010 ◽  
Vol 64 (S 03) ◽  
Author(s):  
S Stenger ◽  
D Nickel ◽  
M Wagner ◽  
JH Ficker ◽  
C Schumann
Keyword(s):  
Alveolar Macrophages ◽  
Human Alveolar Macrophages

Ethanol Metabolism in Vivo and the Role of Hepatic Microsomal Ethanol Oxidation

1972 ◽  
Vol 33 (3) ◽  
pp. 751-755 ◽  
Author(s):  
Mary K. Roach ◽  
Myrna Khan ◽  
Marguerite Knapp ◽  
W. N. Reese
Keyword(s):  
Ethanol Oxidation ◽  
Ethanol Metabolism

scholarly journals Bacillus anthracis Spores Stimulate Cytokine and Chemokine Innate Immune Responses in Human Alveolar Macrophages through Multiple Mitogen-Activated Protein Kinase Pathways

2006 ◽  
Vol 74 (8) ◽  
pp. 4430-4438 ◽  
Author(s):  
Kaushik Chakrabarty ◽  
Wenxin Wu ◽  
J. Leland Booth ◽  
Elizabeth S. Duggan ◽  
K. Mark Coggeshall ◽  
...  
Keyword(s):  
Immune System ◽  
Bacillus Anthracis ◽  
Alveolar Macrophages ◽  
Innate Immune System ◽  
Innate Immune ◽  
Mitogen Activated Protein Kinase ◽  
Tnf Α ◽  
Human Alveolar Macrophages ◽  
Mitogen Activated Protein ◽  
Multiple Signaling

ABSTRACT Contact with the human alveolar macrophage plays a key role in the innate immune response to Bacillus anthracis spores. Because there is a significant delay between the initial contact of the spore with the host and clinical evidence of disease, there appears to be temporary containment of the pathogen by the innate immune system. Therefore, the early macrophage response to Bacillus anthracis exposure is important in understanding the pathogenesis of this disease. In this paper, we studied the initial events after exposure to spores, beginning with the rapid internalization of spores by the macrophages. Spore exposure rapidly activated the mitogen-activated protein kinase signaling pathways extracellular signal-regulated kinase, c-Jun-NH2-terminal kinase, and p38. This was followed by the transcriptional activation of cytokine and primarily monocyte chemokine genes as determined by RNase protection assays. Transcriptional induction is reflected at the translational level, as interleukin-1α (IL-1α), IL-1β, IL-6, and tumor necrosis factor alpha (TNF-α) cytokine protein levels were markedly elevated as determined by enzyme-linked immunosorbent assay. Induction of IL-6 and TNF-α, and, to a lesser extent, IL-1α and IL-1β, was partially inhibited by the blockade of individual mitogen-activated protein kinases, while the complete inhibition of cytokine induction was achieved when multiple signaling pathway inhibitors were used. Taken together, these data clearly show activation of the innate immune system in human alveolar macrophages by Bacillus anthracis spores. The data also show that multiple signaling pathways are involved in this cytokine response. This report is the first comprehensive examination of this process in primary human alveolar macrophages.

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