scholarly journals Chronic Ethanol Exposure and Withdrawal Impair Synaptic GABA A Receptor‐Mediated Neurotransmission in Deep‐Layer Prefrontal Cortex

2019 ◽  
Vol 43 (5) ◽  
pp. 822-832 ◽  
Author(s):  
Benjamin A. Hughes ◽  
John Peyton Bohnsack ◽  
Todd K. O'Buckley ◽  
Melissa A. Herman ◽  
A. Leslie Morrow
Keyword(s):  
Prefrontal Cortex ◽  
Deep Layer ◽  
Ethanol Exposure ◽  
Chronic Ethanol ◽  
Gaba A ◽  
Chronic Ethanol Exposure

scholarly journals Chronic ethanol exposure differentially alters neuronal function in the medial prefrontal cortex and dentate gyrus

2020 ◽  
pp. 108438
Author(s):  
Yosef Avchalumov ◽  
Robert J. Oliver ◽  
Wulfran Trenet ◽  
Rocio Erandi Heyer Osorno ◽  
Britta D. Sibley ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Dentate Gyrus ◽  
Medial Prefrontal Cortex ◽  
Ethanol Exposure ◽  
Chronic Ethanol ◽  
Neuronal Function ◽  
Chronic Ethanol Exposure

scholarly journals Effects of chronic ethanol exposure on neuronal function in the prefrontal cortex and extended amygdala

2015 ◽  
Vol 99 ◽  
pp. 735-749 ◽  
Author(s):  
Kristen E. Pleil ◽  
Emily G. Lowery-Gionta ◽  
Nicole A. Crowley ◽  
Chia Li ◽  
Catherine A. Marcinkiewcz ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Ethanol Exposure ◽  
Chronic Ethanol ◽  
Neuronal Function ◽  
Extended Amygdala ◽  
Chronic Ethanol Exposure

scholarly journals Chronic Ethanol Differentially Modulates Glutamate Release from Dorsal and Ventral Prefrontal Cortical Inputs onto Rat Basolateral Amygdala Principal Neurons

2019 ◽  
Author(s):  
Molly M. McGinnis ◽  
Brian C. Parrish ◽  
Ann M. Chappell ◽  
Brian A. McCool
Keyword(s):  
Prefrontal Cortex ◽  
Medial Prefrontal Cortex ◽  
Basolateral Amygdala ◽  
Glutamate Release ◽  
Ethanol Exposure ◽  
Chronic Ethanol ◽  
Sprague Dawley ◽  
Behavioral Alterations ◽  
Release Probability ◽  
Chronic Ethanol Exposure

AbstractThe medial prefrontal cortex (mPFC) and the basolateral amygdala (BLA) have strong reciprocal connectivity. Projections from the BLA to the mPFC can bidirectionally modulate anxiety-related behaviors but it is unclear if the same is true for mPFC to BLA projections. Our laboratory is specifically interested in withdrawal-related anxiety-like behavior and the underlying synaptic plasticity. Here, we use optogenetics and chemogenetics to characterize the neurophysiological and behavioral alterations produced by chronic ethanol exposure and withdrawal on dorsal mPFC/prelimbic (dmPFC/PL) and ventral mPFC (vmPFC/IL) terminals in the BLA. We exposed adult male Sprague-Dawley rats to chronic intermittent ethanol (CIE) using vapor chambers, measured anxiety-like behavior on the elevated zero maze (EZM), and used electrophysiology to record glutamatergic and GABAergic responses in BLA principal neurons. We found that 24-hour withdrawal following a 7-day CIE exposure significantly increased the glutamate release probability from PL/dmPFC terminals, but significantly decreases the glutamate release probability from IL/vmPFC terminals. Chemogenetic inhibition of PL/dmPFC terminals in the BLA attenuated the increased withdrawal-dependent, anxiety-like behavior. These data demonstrate that chronic ethanol exposure and withdrawal strengthens the PL/dmPFC – BLA pathway but weakens the IL/vmPFC – BLA pathway. Moreover, we provide novel evidence that the PL/dmPFC – BLA pathway can modulate anxiety-like behavior. These findings suggest that mPFC-BLA circuits known to regulate the acquisition of aversive behaviors are up-regulated by chronic ethanol while those involved with the extinction of these behaviors are down-regulated.Significance StatementAccumulating evidence suggests that the medial prefrontal cortex and its projections to the basolateral amygdala bidirectionally modulate fear-related behaviors. Since the neuronal circuits for fear and anxiety are thought to overlap, we sought to examine the role of prelimbic and infralimbic subdivisions of the medial prefrontal cortex and their inputs to the basolateral amygdala in regulating anxiety. Specifically, we focused on alcohol withdrawal-induced anxiety-like behavior, which is a commonly reported cause of relapse in human alcoholics. In our study, we used optogenetics and chemogenetics to demonstrate, for the first time, that withdrawal from chronic ethanol exposure strengthens prelimbic synapses, but weakens infralimbic synapses in the basolateral amygdala and that inhibiting glutamate release from prelimbic terminal in the basolateral amygdala reduces anxiety-like behavior.

Chronic ethanol exposure induces alterations in the nucleocytoplasmic transport in growing astrocytes

2008 ◽  
Vol 106 (4) ◽  
pp. 1914-1928 ◽  
Author(s):  
María Pilar Marín ◽  
Mónica Tomas ◽  
Guillermo Esteban-Pretel ◽  
Luis Megías ◽  
Carmen López-Iglesias ◽  
...  
Keyword(s):  
Nucleocytoplasmic Transport ◽  
Ethanol Exposure ◽  
Chronic Ethanol ◽  
Chronic Ethanol Exposure

Skeletal Toxicity Associated with Chronic Ethanol Exposure in a Rat Model Using Total Enteral Nutrition

2002 ◽  
Vol 301 (3) ◽  
pp. 1132-1138 ◽  
Author(s):  
Elizabeth C. Brown ◽  
Daniel S. Perrien ◽  
Terry W. Fletcher ◽  
David J. Irby ◽  
James Aronson ◽  
...  
Keyword(s):  
Enteral Nutrition ◽  
Rat Model ◽  
Ethanol Exposure ◽  
Chronic Ethanol ◽  
Chronic Ethanol Exposure ◽  
Total Enteral Nutrition
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