scholarly journals The Impact of Past and Current Alcohol Consumption Patterns on Progression of Carotid Intima‐Media Thickness Among Women and Men Living with HIV Infection

2019 ◽  
Vol 43 (4) ◽  
pp. 695-703 ◽  
Author(s):  
Natalie E. Chichetto ◽  
Michael W. Plankey ◽  
Alison G. Abraham ◽  
David S. Sheps ◽  
Nicole Ennis ◽  
...  
Keyword(s):  
Alcohol Consumption ◽  
Hiv Infection ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Consumption Patterns ◽  
Media Thickness ◽  
Living With Hiv ◽  
The Impact ◽  
Current Alcohol

scholarly journals Plasma tissue factor and immune activation are associated with carotid intima–media thickness progression in treated HIV infection

AIDS ◽  
2020 ◽  
Vol 34 (4) ◽  
pp. 519-528 ◽  
Author(s):  
Denise C. Hsu ◽  
Yi Fei Ma ◽  
Amrit Narwan ◽  
Smruti Rahalkar ◽  
Adam Rupert ◽  
...  
Keyword(s):  
Hiv Infection ◽  
Tissue Factor ◽  
Immune Activation ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Media Thickness

The effect of HIV infection, antiretroviral therapy on carotid intima-media thickness: A systematic review and meta-analysis

Life Sciences ◽  
2019 ◽  
Vol 235 ◽  
pp. 116851 ◽  
Author(s):  
Titus F. Msoka ◽  
Gary P. Van Guilder ◽  
Marceline van Furth ◽  
Yvo Smulders ◽  
Sebastian J. Meek ◽  
...  
Keyword(s):  
Systematic Review ◽  
Antiretroviral Therapy ◽  
Hiv Infection ◽  
Meta Analysis ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Media Thickness

Abstract 2648: Design of Carotid Intima-Media Thickness Trials

Circulation ◽  
2008 ◽  
Vol 118 (suppl_18) ◽  
Author(s):  
Gregory W Evans ◽  
Mike K Palmer ◽  
Daniel H O’Leary ◽  
John R Crouse ◽  
Michiel L Bots ◽  
...  
Keyword(s):  
Sample Size ◽  
Treatment Effect ◽  
Subclinical Atherosclerosis ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Double Blind ◽  
Aged Patients ◽  
Media Thickness ◽  
The Impact

Carotid artery intima-media thickness (CIMT) assessed by B-mode ultrasound is an accepted marker for subclinical atherosclerosis commonly used in clinical trials. Their sample size and power calculations apply 2-sample independent t-tests and within group variance in progression rates from the literature. However, this approach obscures the impact of differences in study designs including length of follow-up and differences in the number of and interval between ultrasound scans. These effects can be assessed using common sample size formula for longitudinal models, but this approach requires decomposition of the total variance into between and within subject components that have not generally been reported in the literature. Here, we derive these variance components for the Measuring Effects on intima-media Thickness: an Evaluation of Rosuvastatin (METEOR) study, a randomized, double-blind trial that demonstrated treatment with 40 mg rosuvastatin significantly slowed CIMT progression in middle-aged patients with a low Framingham risk of coronary heart disease and subclinical atherosclerosis (baseline maximum CIMT ≥1.2-<3.5mm). We examined the impact of differing follow-up periods, use of intermediate scans, and use of duplicate scans using both sample size calculations and actual analyses based on subsets of the METEOR data. Reductions in study length or number of scans result in increased variances and larger sample sizes to detect a given treatment effect. Table shows the impact of duplicate scans at baseline and end of the 2-year study, with and without intermediate scans performed every 6 months, on the sample size required to detect a treatment effect of 0.012 mm/year. These results underscore the importance of considering the number and spacing of ultrasound exams explicitly during study design, and suggest that reductions in scanning frequency may seriously erode study power and/or increase costs by requiring recruitment of additional subjects.

Complementary Impact of Carotid Intima–Media Thickness With Plaque in Associations With Noncardiac Arterial Vascular Events

Angiology ◽  
2019 ◽  
Vol 71 (2) ◽  
pp. 122-130 ◽  
Author(s):  
Andrea Kolkenbeck-Ruh ◽  
Angela J. Woodiwiss ◽  
Talib Monareng ◽  
Eitzaz Sadiq ◽  
Philanathi Mabena ◽  
...  
Keyword(s):  
Young Patients ◽  
Intima Media Thickness ◽  
Limb Ischemia ◽  
Carotid Intima Media Thickness ◽  
Receiver Operating Curve ◽  
Vascular Events ◽  
Thrombotic Occlusion ◽  
Media Thickness ◽  
Improved Performance ◽  
The Impact

The ability of carotid intima–media thickness (IMT) to predict risk beyond plaque is controversial. In 952 participants (critical limb ischemia [CLI] or stroke, n = 473; community, n = 479), we assessed whether relationships with events for IMT complement the impact of plaque in young patients depending on the extent of thrombotic versus atherosclerotic disease. The extent of atherosclerotic versus thrombotic occlusion was determined in 54 patients with CLI requiring amputations. Thrombotic occlusion in CLI was associated with younger age ( P < .0001) and less plaque ( P = .02). Independent relations between plaque and CLI were noted in older (>50 years; P < .005 to <.0001) but not younger ( P > .38) participants, while independent relations between plaque and stroke ( P < .005 to <.0001) and between IMT and CLI ( P < .0001) were noted in younger participants. Although in performance (area under the receiver operating curve) for event detection, IMT thresholds failed to add to plaque alone in older patients (0.680 ± 0.020 vs 0.664 ± 0.017, P = .27), IMT improved performance for combined stroke and CLI detection when added to plaque in younger patients (0.719 ± 0.023 vs 0.631 ± 0.026, P < .0001). Because in younger participants the high prevalence of thrombotic occlusion in CLI is associated with less plaque, IMT adds information in associations with arterial vascular events.

scholarly journals HIV Infection Is Not Associated with Carotid Intima-Media Thickness in Brazil: A Cross-Sectional Analysis from the INI/ELSA-Brasil Study

PLoS ONE ◽  
2016 ◽  
Vol 11 (7) ◽  
pp. e0158999 ◽  
Author(s):  
Antonio G. Pacheco ◽  
Beatriz Grinsztejn ◽  
Maria de Jesus M. da Fonseca ◽  
Rosane Härter Griep ◽  
Paulo Lotufo ◽  
...  
Keyword(s):  
Hiv Infection ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Cross Sectional ◽  
Media Thickness ◽  
Cross Sectional Analysis ◽  
Sectional Analysis
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