Prevalence of Prenatal Alcohol Exposure in the State of Texas as Assessed by Phosphatidylethanol in Newborn Dried Blood Spot Specimens

2017 ◽  
Vol 41 (5) ◽  
pp. 1004-1011 ◽  
Author(s):  
Ludmila N. Bakhireva ◽  
Janet Sharkis ◽  
Shikhar Shrestha ◽  
Tristan J. Miranda-Sohrabji ◽  
Sonnie Williams ◽  
...  
Keyword(s):  
Prenatal Alcohol Exposure ◽  
Alcohol Exposure ◽  
The State ◽  
Dried Blood Spot ◽  
Prenatal Alcohol ◽  
Blood Spot

scholarly journals Retrospective assessment of prenatal alcohol exposure by detection of phosphatidylethanol in stored dried blood spot cards: An objective method for determining prevalence rates of alcohol consumption during pregnancy

2015 ◽  
Vol 4 (2) ◽  
pp. 131-137 ◽  
Author(s):  
Aileen E. Baldwin ◽  
Joseph Jones ◽  
Mary Jones ◽  
Charles Plate ◽  
Douglas Lewis
Keyword(s):  
Alcohol Consumption ◽  
Prenatal Alcohol Exposure ◽  
Alcohol Exposure ◽  
Dried Blood Spot ◽  
Objective Method ◽  
Prevalence Rates ◽  
Retrospective Assessment ◽  
Prenatal Alcohol ◽  
Metabolic Screening ◽  
Blood Spot

Baldwin, A., Jones, J., Jones, M., Plate, C., & Lewis, D. (2015). Retrospective assessment of prenatal alcohol exposure by detection of phosphatidylethanol in stored dried blood spot cards: An objective method for determining prevalence rates of alcohol consumption during pregnancy. The International Journal Of Alcohol And Drug Research, 4(2), 131-137. doi:http://dx.doi.org/10.7895/ijadr.v4i2.209Aims: To analyze the efficacy of screening banked newborn dried blood spots (DBS) for detection of phosphatidylethanol(PEth), a direct alcohol biomarker, with the purpose of performing a retrospective assessment of statewide prevalence rates ofalcohol consumption in late pregnancy that results in risky prenatal alcohol exposure.Design: Residual DBS samples collected for newborn screening and stored by a state department of public health wereexamined for concentrations of PEth. The prevalence of prenatal alcohol exposure, as determined by this direct alcoholbiomarker, was compared to prevalence rates of alcohol consumption during pregnancy that have been derived from multiplestate-based and national studies using maternal self-report surveys.Setting: DBS cards representative of the general newborn population were collected from multiple hospitals across a singlemidwestern state.Participants: Two hundred fifty anonymous newborn DBS collected for routine metabolic screening in a midwestern state wererequested through the Virtual Repository of Dried Blood Spots.Measures: Concentrations of PEth, a highly specific biomarker of alcohol consumption, were analyzed using a liquidchromatography–tandem mass spectrometry method validated by our laboratory.Findings: Of 2 50 D BS e xamined, 4 % w ere p ositive f or PEth ( PEth ≥ 8 n g/ml) which is indicative of exposure to maternalalcohol consumption during the last month of pregnancy.Conclusions: Detection of PEth from newborn DBS cards can identify prenatal alcohol exposure and also be used forretrospective surveillance of alcohol consumption during the last three to four weeks of pregnancy, using specimens that arecollected for routine metabolic screening and stored by many state health departments.

Complex Trauma and Prenatal Alcohol Exposure: Clinical Implications

2012 ◽  
Vol 13 (2) ◽  
pp. 32-42 ◽  
Author(s):  
Yvette D. Hyter
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Child Development ◽  
Academic Outcomes ◽  
Complex Trauma ◽  
Prenatal Alcohol Exposure ◽  
Alcohol Exposure ◽  
Clinical Implications ◽  
Prenatal Alcohol ◽  
The Brain

Abstract Complex trauma resulting from chronic maltreatment and prenatal alcohol exposure can significantly affect child development and academic outcomes. Children with histories of maltreatment and those with prenatal alcohol exposure exhibit remarkably similar central nervous system impairments. In this article, I will review the effects of each on the brain and discuss clinical implications for these populations of children.

Prenatal alcohol exposure and signs of minor neurological dysfunction at preschool age

2000 ◽  
Vol 42 (8) ◽  
pp. 508-514 ◽  
Author(s):  
Béatrice Larroque ◽  
Monique Kaminski ◽  
Phillipe Dehaene ◽  
Damien Subtil ◽  
Denis Querleu
Keyword(s):  
Prenatal Alcohol Exposure ◽  
Alcohol Exposure ◽  
Preschool Age ◽  
Neurological Dysfunction ◽  
Minor Neurological Dysfunction ◽  
Prenatal Alcohol

Impact of Moderate Prenatal Alcohol Exposure on Problem Behaviors in Preschool and School Children

2014 ◽  
Vol 46 (2) ◽  
pp. 89-100 ◽  
Author(s):  
Manuela Pfinder ◽  
Stefan Liebig ◽  
Reinhold Feldmann
Keyword(s):  
Problem Behaviors ◽  
Tobacco Smoke ◽  
Prenatal Alcohol Exposure ◽  
Alcohol Exposure ◽  
Smoke Exposure ◽  
Low Ses ◽  
German Health ◽  
Kiggs Study ◽  
Strengths And Difficulties ◽  
Prenatal Alcohol

Data on the relation between moderate prenatal alcohol exposure (PAE) and behavioral disorders are inconsistent, and this raises new questions. We examined (1) the association between moderate PAE and problem behaviors and (2) whether these associations differed by levels of socioeconomic status (SES), fetal smoke exposure, or exposure to environmental tobacco smoke (ETS). Data were taken from the German Health Interview and Examination Survey for Children and Adolescents (KiGGS) study. Parents evaluated children’s behaviors using the Strengths and Difficulties Questionnaire (SDQ). Results showed a slight, but insignificant, increase of problem behaviors in children with moderate PAE. In 3- to 6-year-olds, PAE had a stronger effect on hyperactivity/inattention in combination with fetal smoke exposure (odds ratio = 2.82), than did PAE alone. Effects were not stronger in low-SES children, but they were stronger in children with ETS. We conclude that moderate PAE might have adverse effects on neurodevelopment, with stronger effects in disadvantaged populations. To confirm our preliminary findings, further research should be conducted.

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