scholarly journals Myeloid-MyD88 Contributes to Ethanol-Induced Liver Injury in Mice Linking Hepatocellular Death to Inflammation

2017 ◽  
Vol 41 (4) ◽  
pp. 719-726 ◽  
Author(s):  
Hao Zhou ◽  
Minja Yu ◽  
Sanjoy Roychowdhury ◽  
Carlos Sanz-Garcia ◽  
Katherine A. Pollard ◽  
...  
Keyword(s):  
Liver Injury ◽  
Hepatocellular Death

Hsp72 protects against liver injury via attenuation of hepatocellular death, oxidative stress, and JNK signaling

2018 ◽  
Vol 68 (5) ◽  
pp. 996-1005 ◽  
Author(s):  
Kateryna Levada ◽  
Nurdan Guldiken ◽  
Xiaoji Zhang ◽  
Giovanna Vella ◽  
Fa-Rong Mo ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Liver Injury ◽  
Jnk Signaling ◽  
Hepatocellular Death

scholarly journals Endoplasmic Reticulum Stress-induced Hepatocellular Death Pathways Mediate Liver Injury and Fibrosis via Stimulator of Interferon Genes

2016 ◽  
Vol 291 (52) ◽  
pp. 26794-26805 ◽  
Author(s):  
Arvin Iracheta-Vellve ◽  
Jan Petrasek ◽  
Benedek Gyongyosi ◽  
Abhishek Satishchandran ◽  
Patrick Lowe ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Liver Injury ◽  
Endoplasmic Reticulum Stress ◽  
Hepatocellular Death

scholarly journals Autophagy induced by exogenous bile acids is therapeutic in a model of α-1-AT deficiency liver disease

2016 ◽  
Vol 311 (1) ◽  
pp. G156-G165 ◽  
Author(s):  
Youcai Tang ◽  
Peter Fickert ◽  
Michael Trauner ◽  
Nancy Marcus ◽  
Keith Blomenkamp ◽  
...  
Keyword(s):  
Cell Death ◽  
Liver Disease ◽  
Liver Injury ◽  
Protein Accumulation ◽  
Ki 67 ◽  
Compensatory Proliferation ◽  
At Deficiency ◽  
A1at Deficiency ◽  
Hepatocellular Death ◽  
Z Protein

The bile acid nor-ursodeoxycholic acid (norUDCA) has many biological actions, including antiapoptotic effects. Homozygous PIZZ α-1-antitrypsin (A1AT)-deficient humans are known to be at risk for liver disease, cirrhosis, and liver cancer as a result of the accumulation of the toxic, A1AT mutant Z protein within hepatocytes. This accumulation triggers cell death in the hepatocytes with the largest mutant Z-protein burdens, followed by compensatory proliferation. Proteolysis pathways within the hepatocyte, including autophagy, act to reduce the intracellular burden of A1AT Z protein. We hypothesized that norUDCA would reduce liver cell death and injury in A1AT deficiency. We treated groups of PiZ transgenic mice and wild-type mice with norUDCA or vehicle, orally, and examined the effects on the liver. The PiZ mouse is the best model of A1AT liver injury and recapitulates many features of the human liver disease. Mice treated with norUDCA demonstrated reduced hepatocellular death by compensatory hepatocellular proliferation as determined by bromodeoxyuridine incorporation (3.8% control, 0.88% treated, P < 0.04). Ki-67 staining as a marker for hepatocellular senescence and death was also reduced ( P < 0.02). Reduced apoptotic signaling was associated with norUDCA, including reduced cleavage of caspases-3, -7, and -8 (all P < 0.05). We determined that norUDCA was associated with a >70% reduction in intrahepatic mutant Z protein ( P < 0.01). A 32% increase in hepatic autophagy associated with norUDCA was the likely mechanism. norUDCA administration is associated with increased autophagy, reduced A1AT protein accumulation, and reduced liver injury in a model of A1AT deficiency.

Hsp72 overexpression protects from liver injury and hepatocellular death via attenuation of oxidative stress and JNK-signaling

2016 ◽  
Vol 54 (12) ◽  
pp. 1343-1404
Author(s):  
K Levada ◽  
N Guldiken ◽  
G Vella ◽  
LP James ◽  
J Haybaeck ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Liver Injury ◽  
Jnk Signaling ◽  
Hepatocellular Death

Effects of Steroids on Fetal Rat Liver

1969 ◽  
Vol 27 ◽  
pp. 350-351
Author(s):  
F. G. Zaki
Keyword(s):  
Liver Injury ◽  
Rat Liver ◽  
Fetal Liver ◽  
Dosage Level ◽  
Maternal Plasma ◽  
Methyl Prednisolone ◽  
Fetal Rat ◽  
Toxic Agents ◽  
Fetal Rat Liver ◽  
Neonatal Liver

Fetal and neonatal liver injury induced by agents circulating in maternal plasma, even though well recognized, its morphological manifestations are not yet established. As part of our studies of fetal and neonatal liver injury induced by maternal nutritional disorders, metabolic impairment and toxic agents, the effects of two anti-inflammatory steroids have been recently inves tigated.Triamcinolone and methyl prednisolone were injected each in a group of rats during pregnancy at a-dosage level of 2 mgm three times a week. Fetal liver was studied at 18 days of gestation. Litter size and weight markedly decreased than those of control rats. Stillbirths and resorption were of higher incidence in the triamcinolone group than in those given the prednisolone.

Proteinase activated receptor (PAR)-2 agonistic peptide protects from Th-1 mediated liver injury in mice

2001 ◽  
Vol 120 (5) ◽  
pp. A27-A27
Author(s):  
S FLORUCCI ◽  
A MENCARELLI ◽  
B PALAZZETTI ◽  
E DISTRUTTI ◽  
G CIRINO ◽  
...  
Keyword(s):  
Liver Injury ◽  
Th 1

Toll-like receptor 2 signaling is important for fas ligand on NKT cells, may contribute to liver injury induced by Salmonella infection

2001 ◽  
Vol 120 (5) ◽  
pp. A357-A357
Author(s):  
H SHIMIZU ◽  
Y FUKUDA ◽  
I NAKANO ◽  
Y KATANO ◽  
K NAGANO ◽  
...  
Keyword(s):  
Liver Injury ◽  
Fas Ligand ◽  
Nkt Cells ◽  
Toll Like Receptor ◽  
Salmonella Infection ◽  
Toll Like Receptor 2
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