No Wrong Doors: Findings from a Critical Review of Behavioral Randomized Clinical Trials for Individuals with Co-Occurring Alcohol/Drug Problems and Posttraumatic Stress Disorder

2017 ◽  
Vol 41 (4) ◽  
pp. 681-702 ◽  
Author(s):  
Tracy L. Simpson ◽  
Keren Lehavot ◽  
Ismene L. Petrakis
Keyword(s):  
Posttraumatic Stress Disorder ◽  
Clinical Trials ◽  
Posttraumatic Stress ◽  
Critical Review ◽  
Randomized Clinical Trials ◽  
Stress Disorder ◽  
Drug Problems

scholarly journals The role of beta-adrenolytic drugs in treating anxiety disorders

2018 ◽  
Vol 19 (3) ◽  
pp. 209-224
Author(s):  
Żaneta Brudkowska ◽  
Małgorzata Tomczyk ◽  
Katarzyna Jusiak ◽  
Hanna Karakuła-Juchnowicz ◽  
Ewa Rudnicka-Drożak
Keyword(s):  
Posttraumatic Stress Disorder ◽  
Clinical Trials ◽  
Anxiety Disorders ◽  
Posttraumatic Stress ◽  
Randomized Clinical Trials ◽  
Stress Disorder ◽  
Therapeutic Potential ◽  
Beta Blockers ◽  
Panic Attacks ◽  
Pubmed Database

Summary Introduction: Beta blockers are mainly used in treating cardiovascular diseases. However, it has been observed that these drugs have also an anxiolytic potential. Over the years, a number of clinical trials have been conducted aimed at determining the effectiveness of beta blockers in treating anxiety disorders. The aim of the article: The main objective of the article is to present the significance and position of adrenolytic drugs in the pharmacotherapy of anxiety disorders on the basis of available literature. Moreover, the authors also decided to take into account the data from current research results, considering the problem of side effects of using adrenolytic drugs - especially the controversial reports on their effect on the development of affective disorders. Method: An analysis was conducted of articles from Medline/PubMed database, selected on the basis of the following key words: anxiety disorders, beta blockers, adrenolytic drugs, as well as on the basis of their dates of publication: 1960-2017. In order to conduct a reliable and complete review of literature, the authors decided to include works from quite an extended period of time. The articles included in the review were published in Polish and English. Results: The review of articles concerning the treatment of anxiety disorders clearly suggests that propranolol is effective in reducing the frequency of panic attacks and the tendency for avoidance behavior in patients with agoraphobia. Other studies report on potential benefits in terms of early interventional prevention and treating posttraumatic stress disorder with propranolol. However, there is lack of randomized clinical trials concerning the therapeutic effect of other adrenolytic drugs in treating anxiety disorders. Early research works reported that (mainly lipophilic) beta blockers may have a depressogenic effect; however, the latest studies have not confirmed it. The contemporary research on the therapeutic potential of beta blockers in treating anxiety disorders is insufficient. What seems to be most promising, however, are reports concerning the desirable effects of using adrenolytic drugs in treating posttraumatic stress disorder, which implicates the necessity of conducting further research verifying the validity of their application.

scholarly journals Scaling Up: Multisite Open-Label Clinical Trials of MDMA-Assisted Therapy for Severe Posttraumatic Stress Disorder

2021 ◽  
pp. 002216782110236
Author(s):  
Julie B. Wang ◽  
Jessica Lin ◽  
Leah Bedrosian ◽  
Allison Coker ◽  
Ilsa Jerome ◽  
...  
Keyword(s):  
Posttraumatic Stress Disorder ◽  
Clinical Trials ◽  
Posttraumatic Stress ◽  
Clinical Supervision ◽  
Stress Disorder ◽  
The United States ◽  
Health Condition ◽  
Open Label ◽  
Adverse Health Outcomes ◽  
Ptsd Symptom Severity

Background: Posttraumatic stress disorder (PTSD) is a debilitating mental health condition associated with serious adverse health outcomes and functional impairment. Previous MDMA–assisted therapy (MDMA-AT) studies have shown promising results in single site studies. Two open-label studies tested this modality in multisite clinical trials to assess the feasibility of scaling this manualized therapy across 14 North American sites. Method: Cotherapist dyads were trained in the manualized MDMA-AT protocol and administered three experimental sessions 3 to 5 weeks apart among participants with severe PTSD. Cotherapist dyads were provided clinical supervision and evaluated for protocol adherence by centralized raters. Clinician-Administered PTSD Scale for DSM-5 (CAPS-5) assessed change in symptoms severity. Results: Adherence rating scores were high across cotherapist dyads ( M = 95.08%, SD = 3.70%) and sites ( M = 95.23%, SD = 2.20%). CAPS-5 scores decreased following 3 MDMA-AT sessions at 18 weeks post baseline (Δ M = −29.99, Δ SD = 13.45, p < .0001, n = 37, Cohen’s d = 2.2, confidence interval [1.97, 2.47]). MDMA was well tolerated. Conclusions: These findings corroborate previous results that MDMA-AT can achieve significant improvements in PTSD symptom severity and demonstrate scalability of manualized therapy across clinic sites in the United States and Canada.

scholarly journals Trauma exposure and posttraumatic stress disorder in adults with severe mental illness: A critical review

2011 ◽  
Vol 31 (6) ◽  
pp. 883-899 ◽  
Author(s):  
Anouk L. Grubaugh ◽  
Heidi M. Zinzow ◽  
Lisa Paul ◽  
Leonard E. Egede ◽  
B. Christopher Frueh
Keyword(s):  
Posttraumatic Stress Disorder ◽  
Mental Illness ◽  
Severe Mental Illness ◽  
Posttraumatic Stress ◽  
Critical Review ◽  
Stress Disorder ◽  
Trauma Exposure

scholarly journals Acupuncture for Posttraumatic Stress Disorder: A Systematic Review of Randomized Controlled Trials and Prospective Clinical Trials

2013 ◽  
Vol 2013 ◽  
pp. 1-12 ◽  
Author(s):  
Young-Dae Kim ◽  
In Heo ◽  
Byung-Cheul Shin ◽  
Cindy Crawford ◽  
Hyung-Won Kang ◽  
...  
Keyword(s):  
Systematic Review ◽  
Posttraumatic Stress Disorder ◽  
Clinical Trials ◽  
Randomized Controlled Trials ◽  
Posttraumatic Stress ◽  
Stress Disorder ◽  
Meta Analysis ◽  
Favorable Effect ◽  
Controlled Trials ◽  
Randomized Controlled

To evaluate the current evidence for effectiveness of acupuncture for posttraumatic stress disorder (PTSD) in the form of a systematic review, a systematic literature search was conducted in 23 electronic databases. Grey literature was also searched. The key search terms were “acupuncture” and “PTSD.” No language restrictions were imposed. We included all randomized or prospective clinical trials that evaluated acupuncture and its variants against a waitlist, sham acupuncture, conventional therapy control for PTSD, or without control. Four randomized controlled trials (RCTs) and 2 uncontrolled clinical trials (UCTs) out of 136 articles in total were systematically reviewed. One high-quality RCT reported that acupuncture was superior to waitlist control and therapeutic effects of acupuncture and cognitive-behavioral therapy (CBT) were similar based on the effect sizes. One RCT showed no statistical difference between acupuncture and selective serotonin reuptake inhibitors (SSRIs). One RCT reported a favorable effect of acupoint stimulation plus CBT against CBT alone. A meta-analysis of acupuncture plus moxibustion versus SSRI favored acupuncture plus moxibustion in three outcomes. This systematic review and meta-analysis suggest that the evidence of effectiveness of acupuncture for PTSD is encouraging but not cogent. Further qualified trials are needed to confirm whether acupuncture is effective for PTSD.

scholarly journals A factor analysis of posttraumatic stress disorder symptoms using data pooled from two venlafaxine extended‐release clinical trials

2013 ◽  
Vol 3 (6) ◽  
pp. 738-746 ◽  
Author(s):  
Dan J. Stein ◽  
Barbara O. Rothbaum ◽  
David S. Baldwin ◽  
Annette Szumski ◽  
Ronald Pedersen ◽  
...  
Keyword(s):  
Posttraumatic Stress Disorder ◽  
Clinical Trials ◽  
Factor Analysis ◽  
Posttraumatic Stress ◽  
Extended Release ◽  
Stress Disorder ◽  
Posttraumatic Stress Disorder Symptoms ◽  
Using Data
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