scholarly journals Differences Between Treatment-Seeking and Nontreatment-Seeking Alcohol-Dependent Research Participants: An Exploratory Analysis

2017 ◽  
Vol 41 (2) ◽  
pp. 414-420 ◽  
Author(s):  
Matthew C.H. Rohn ◽  
Mary R. Lee ◽  
Samuel B. Kleuter ◽  
Melanie L. Schwandt ◽  
Daniel E. Falk ◽  
...  
Keyword(s):  
Exploratory Analysis ◽  
Treatment Seeking ◽  
Research Participants ◽  
Alcohol Dependent

scholarly journals Cortical Glutamate and GABA Changes During Early Abstinence in Alcohol Dependence and Their Associations With Benzodiazepine Medication

2021 ◽  
Vol 12 ◽  
Author(s):  
Guoying Wang ◽  
Wolfgang Weber-Fahr ◽  
Ulrich Frischknecht ◽  
Derik Hermann ◽  
Falk Kiefer ◽  
...  
Keyword(s):  
Alcohol Dependence ◽  
Alcohol Withdrawal ◽  
Withdrawal Symptoms ◽  
Internal Quality ◽  
Treatment Seeking ◽  
Withdrawal Period ◽  
Cross Sectional ◽  
Longitudinal Changes ◽  
Single Voxel ◽  
Alcohol Dependent

In this report, we present cross-sectional and longitudinal findings from single-voxel MEGA-PRESS MRS of GABA as well as Glu, and Glu + glutamine (Glx) concentrations in the ACC of treatment-seeking alcohol-dependent patients (ADPs) during detoxification (first 2 weeks of abstinence). The focus of this study was to examine whether the amount of benzodiazepine administered to treat withdrawal symptoms was associated with longitudinal changes in Glu, Glx, and GABA. The tNAA levels served as an internal quality reference; in agreement with the vast majority of previous reports, these levels were initially decreased and normalized during the course of abstinence in ADPs. Our results on Glu and Glx support hyperglutamatergic functioning during alcohol withdrawal, by showing higher ACC Glu and Glx levels on the first day of detoxification in ADPs. Withdrawal severity is reflected in cumulative benzodiazepine requirements throughout the withdrawal period. The importance of withdrawal severity for the study of GABA and Glu changes in early abstinence is emphasized by the benzodiazepine-dependent Glu, Glx, and GABA changes observed during the course of abstinence.

scholarly journals Familial association of abstinent remission from alcohol use disorder in first-degree relatives of alcohol-dependent treatment-seeking probands

Addiction ◽  
2017 ◽  
Vol 112 (11) ◽  
pp. 1909-1917 ◽  
Author(s):  
Vivia V. McCutcheon ◽  
Marc A. Schuckit ◽  
John R. Kramer ◽  
Grace Chan ◽  
Howard J. Edenberg ◽  
...  
Keyword(s):  
Alcohol Use ◽  
Alcohol Use Disorder ◽  
Treatment Seeking ◽  
First Degree Relatives ◽  
Familial Association ◽  
Alcohol Dependent

scholarly journals Exposure to traumatic events among treatment-seeking, alcohol-dependent women and men without PTSD

2010 ◽  
Vol 23 (5) ◽  
pp. 649-652 ◽  
Author(s):  
Candace S. Johnson ◽  
Jaimee L. Heffner ◽  
Thomas J. Blom ◽  
Robert M. Anthenelli
Keyword(s):  
Traumatic Events ◽  
Treatment Seeking ◽  
Alcohol Dependent

scholarly journals Ondansetron and sertraline may interact with 5-HTTLPR and DRD4 polymorphisms to reduce drinking in non-treatment seeking alcohol-dependent women: Exploratory findings

Alcohol ◽  
2014 ◽  
Vol 48 (6) ◽  
pp. 515-522 ◽  
Author(s):  
George A. Kenna ◽  
William H. Zywiak ◽  
Robert M. Swift ◽  
John E. McGeary ◽  
James S. Clifford ◽  
...  
Keyword(s):  
Treatment Seeking ◽  
Alcohol Dependent

Impact of childhood trauma on co-morbidity among alcohol dependent patients: Controlled study

2017 ◽  
Vol 41 (S1) ◽  
pp. s864-s864
Author(s):  
D. Gulec Oyekcin ◽  
A. Gurgen
Keyword(s):  
Alcohol Use ◽  
Psychiatric Disorders ◽  
Childhood Trauma ◽  
Emotional Abuse ◽  
Alcohol Use Disorders ◽  
Controlled Study ◽  
Treatment Seeking ◽  
Co Morbidity ◽  
Physical Neglect ◽  
Alcohol Dependent

IntroductionChildhood trauma has been found to be prevalent in treatment-seeking alcoholics.ObjectivesWe aimed to investigate the childhood trauma prevalence among alcohol dependent patients and the prevalence of psychiatric co-morbidity.MethodsA total of 61 participants were assessed; 35 treatment-seeking alcohol dependent patients and 26 age-gender matched controls in the addiction division of psychiatry department of Çanakkale Onsekiz Mart University. After describing the study and obtaining informed consent, participants were assessed with demographic questionnaires, followed by the structured clinical interview for the DSM-IV-TR and childhood trauma questionnaire (CTQ-28).ResultThe 91.4% of the patients were male, mean age was 42.03 ± 12.9. The overall prevalence of CTE of the alcohol dependent patients was (88.6%) higher than the control (42.3%) group. Respectively the prevalence of physical neglect was 80%, emotional neglect 74.3%, emotional abuse was 51.4%, physical abuse 40% and sexual abuse 28.6%. For psychiatric disorders 96.8% of the alcohol dependent patients with childhood trauma reported any of the psychiatric disorders, 64.5% ever having a mood disorder with 25.8% ever having any anxiety disorders, and 16.1% ever having attention and hyperactivity disorder. The most common psychiatric co-morbidity was found to be as depression (58.1%).ConclusionsIn conclusion alcohol use disorders are thought to be associated with childhood trauma. Patients with alcohol use disorders are exposed to have more childhood trauma. Childhood trauma is associated with psychiatric co-morbidity especially depression. We have to ask for childhood trauma in alcohol dependent patients with psychiatric co-morbidity.Disclosure of interestThe authors have not supplied their declaration of competing interest.

scholarly journals Stress moderates the effect of childhood trauma and adversity on recent drinking in treatment-seeking alcohol-dependent men.

2014 ◽  
Vol 82 (3) ◽  
pp. 441-447 ◽  
Author(s):  
Sarah F. Eames ◽  
Michael S. Businelle ◽  
Alina Suris ◽  
Robrina Walker ◽  
Uma Rao ◽  
...  
Keyword(s):  
Childhood Trauma ◽  
Treatment Seeking ◽  
Alcohol Dependent

Baclofen attenuates fMRI alcohol cue reactivity in treatment-seeking alcohol dependent individuals

2019 ◽  
Author(s):  
Warren B. Logge ◽  
Richard W. Morris ◽  
Andrew J. Baillie ◽  
Paul S. Haber ◽  
Kirsten C. Morley
Keyword(s):  
Cue Reactivity ◽  
Treatment Seeking ◽  
Alcohol Dependent
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