Effect of Varenicline Combined with High-Dose Alcohol on Craving, Subjective Intoxication, Perceptual Motor Response, and Executive Cognitive Function in Adults with Alcohol Use Disorders: Preliminary Findings

Terril L. Verplaetse; Brian P. Pittman; Julia M. Shi; Jeanette M. Tetrault; Sabrina Coppola; Sherry A. McKee

doi:10.1111/acer.13110

Effect of Varenicline Combined with High-Dose Alcohol on Craving, Subjective Intoxication, Perceptual Motor Response, and Executive Cognitive Function in Adults with Alcohol Use Disorders: Preliminary Findings

Alcoholism Clinical and Experimental Research ◽

10.1111/acer.13110 ◽

2016 ◽

Vol 40 (7) ◽

pp. 1567-1576 ◽

Cited By ~ 9

Author(s):

Terril L. Verplaetse ◽

Brian P. Pittman ◽

Julia M. Shi ◽

Jeanette M. Tetrault ◽

Sabrina Coppola ◽

...

Keyword(s):

Cognitive Function ◽

Alcohol Use ◽

Motor Response ◽

Alcohol Use Disorders ◽

High Dose ◽

Executive Cognitive Function

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The acute effects of alcohol on state rumination in the laboratory

Psychopharmacology ◽

10.1007/s00213-021-05802-1 ◽

2021 ◽

Author(s):

O. Merve Mollaahmetoglu ◽

Edward Palmer ◽

Emily Maschauer ◽

Melissa C. Nolan ◽

Tobias Stevens ◽

...

Keyword(s):

Alcohol Consumption ◽

Alcohol Use ◽

Negative Mood ◽

Alcohol Use Disorders ◽

Preliminary Evidence ◽

High Dose ◽

Acute Effects ◽

High Doses ◽

Alcohol Related Problems

Abstract Rationale Rumination is a repetitive, negative, self-focused thinking style associated with various forms of psychopathology. Recent studies suggest that rumination increases craving for alcohol and predicts harmful drinking and alcohol-related problems. However, the acute effects of alcohol on rumination have not been previously studied. It is proposed that alcohol may reduce ruminative thinking through decreasing negative mood. Objectives In the present study, we aimed to test the previously unexplored effects of acute alcohol consumption on rumination in a hazardous drinking population. Methods We conducted a randomised placebo-controlled laboratory study to examine the effect of low (0.4 g kg−1) and high doses (0.8 g kg−1) of alcohol on state rumination compared to placebo. Participants completed a rumination induction task prior to receiving drinks. We then measured state rumination and mood at repeated time points; 30 min, 60 min and 90 min post-drinks consumption. Results We found a significant decrease in state rumination in the low-dose alcohol group compared to placebo at 30 min post-alcohol consumption, but no difference was observed between the high-dose alcohol and placebo groups. Mediation analysis provided evidence for an indirect effect of alcohol on state rumination through concurrent changes in negative mood. Conclusions These findings suggest that acute alcohol consumption can regulate negative mood and concurrently rumination, providing preliminary evidence for the role of rumination in alcohol use disorders. Rumination may be a treatment target in alcohol use disorders.

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